SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5koi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_A_BEZA349_0
(D-AMINO ACID OXIDASE)		 5koi ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Brucella
abortus) 		4 / 5 TYR A 147
TYR A 157
ILE A 201
GLY A 191
 NAD  A 300 ( 4.8A)
None
None
None
 1.08A 1kifA-5koiA:
5.4		 1kifA-5koiA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_B_BEZB349_0
(D-AMINO ACID OXIDASE)		 5koi ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Brucella
abortus) 		4 / 5 TYR A 147
TYR A 157
ILE A 201
GLY A 191
 NAD  A 300 ( 4.8A)
None
None
None
 1.08A 1kifB-5koiA:
5.4		 1kifB-5koiA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_C_BEZC349_0
(D-AMINO ACID OXIDASE)		 5koi ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Brucella
abortus) 		4 / 5 TYR A 147
TYR A 157
ILE A 201
GLY A 191
 NAD  A 300 ( 4.8A)
None
None
None
 1.08A 1kifC-5koiA:
5.4		 1kifC-5koiA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_D_BEZD349_0
(D-AMINO ACID OXIDASE)		 5koi ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Brucella
abortus) 		4 / 5 TYR A 147
TYR A 157
ILE A 201
GLY A 191
 NAD  A 300 ( 4.8A)
None
None
None
 1.08A 1kifD-5koiA:
5.4		 1kifD-5koiA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_E_BEZE349_0
(D-AMINO ACID OXIDASE)		 5koi ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Brucella
abortus) 		4 / 5 TYR A 147
TYR A 157
ILE A 201
GLY A 191
 NAD  A 300 ( 4.8A)
None
None
None
 1.08A 1kifE-5koiA:
5.5		 1kifE-5koiA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_F_BEZF349_0
(D-AMINO ACID OXIDASE)		 5koi ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Brucella
abortus) 		4 / 5 TYR A 147
TYR A 157
ILE A 201
GLY A 191
 NAD  A 300 ( 4.8A)
None
None
None
 1.08A 1kifF-5koiA:
5.4		 1kifF-5koiA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_G_BEZG349_0
(D-AMINO ACID OXIDASE)		 5koi ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Brucella
abortus) 		4 / 5 TYR A 147
TYR A 157
ILE A 201
GLY A 191
 NAD  A 300 ( 4.8A)
None
None
None
 1.08A 1kifG-5koiA:
5.4		 1kifG-5koiA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_H_BEZH349_0
(D-AMINO ACID OXIDASE)		 5koi ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Brucella
abortus) 		4 / 5 TYR A 147
TYR A 157
ILE A 201
GLY A 191
 NAD  A 300 ( 4.8A)
None
None
None
 1.07A 1kifH-5koiA:
5.4		 1kifH-5koiA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE9_A_BEZA352_0
(D-AMINO ACID OXIDASE)		 5koi ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Brucella
abortus) 		4 / 5 TYR A 147
TYR A 157
ILE A 201
GLY A 191
 NAD  A 300 ( 4.8A)
None
None
None
 1.10A 1ve9A-5koiA:
5.3		 1ve9A-5koiA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)		 5koi ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Brucella
abortus) 		4 / 5 TYR A 147
TYR A 157
ILE A 201
GLY A 191
 NAD  A 300 ( 4.8A)
None
None
None
 1.13A 2du8G-5koiA:
5.5		 2du8G-5koiA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_J_BEZJ3352_0
(D-AMINO-ACID OXIDASE)		 5koi ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Brucella
abortus) 		4 / 5 TYR A 147
TYR A 157
ILE A 201
GLY A 191
 NAD  A 300 ( 4.8A)
None
None
None
 1.15A 2du8J-5koiA:
5.4		 2du8J-5koiA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 5koi ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Brucella
abortus) 		5 / 12 LEU A 174
ILE A 245
ILE A 183
SER A 141
GLU A 133
 None
 1.20A 3axtA-5koiA:
3.1		 3axtA-5koiA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5koi ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Brucella
abortus) 		5 / 12 LEU A  89
PHE A  76
ILE A  79
ALA A  37
LEU A  36
 None
 1.06A 3n8xA-5koiA:
undetectable		 3n8xA-5koiA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5koi ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Brucella
abortus) 		5 / 12 LEU A  89
PHE A  76
ILE A  79
ALA A  37
LEU A  36
 None
 0.97A 3n8xB-5koiA:
undetectable		 3n8xB-5koiA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 5koi ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Brucella
abortus) 		4 / 8 LEU A 174
GLN A 130
TYR A 178
TYR A 123
 None
 1.35A 3po7A-5koiA:
3.3		 3po7A-5koiA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 5koi ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Brucella
abortus) 		3 / 3 ASP A  87
ARG A   9
ASP A 138
 None
 0.85A 4fzvA-5koiA:
4.7		 4fzvA-5koiA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 5koi ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Brucella
abortus) 		5 / 9 VAL A 185
ALA A 175
TYR A 178
GLY A 139
GLY A 179
 None
 1.30A 4mmbA-5koiA:
undetectable		 4mmbA-5koiA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 5koi ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Brucella
abortus) 		5 / 9 VAL A 185
ALA A 175
TYR A 178
GLY A 139
GLY A 179
 None
 1.30A 4mmeB-5koiA:
undetectable		 4mmeB-5koiA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 5koi ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Brucella
abortus) 		3 / 3 PRO A  51
LEU A  52
HIS A  19
 None
 0.69A 4pevA-5koiA:
2.7		 4pevA-5koiA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 5koi ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Brucella
abortus) 		3 / 3 LEU A 174
ASP A 177
TYR A 178
 None
 0.67A 4qc6B-5koiA:
undetectable		 4qc6B-5koiA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 5koi ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Brucella
abortus) 		4 / 8 ARG A 219
VAL A 221
ASP A 224
ASP A 225
 None
 0.81A 4xqgA-5koiA:
8.1		 4xqgA-5koiA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 5koi ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Brucella
abortus) 		4 / 8 ARG A 219
VAL A 221
ASP A 224
ASP A 225
 None
 0.82A 4xqgB-5koiA:
9.6		 4xqgB-5koiA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 5koi ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Brucella
abortus) 		5 / 12 LEU A 233
ALA A 132
PHE A 125
LEU A 167
VAL A 171
 None
 1.14A 5tudA-5koiA:
undetectable		 5tudA-5koiA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_1
(PROTEASE)		 5koi ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Brucella
abortus) 		5 / 12 GLY A  42
VAL A  61
GLY A  14
ILE A  93
VAL A  75
 None
None
NAD  A 300 (-3.6A)
NAD  A 300 (-3.7A)
None
 1.03A 6dh0B-5koiA:
undetectable		 6dh0B-5koiA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 5koi ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Brucella
abortus) 		4 / 5 PHE A  76
VAL A 119
MET A  13
VAL A  75
 None
 1.42A 6ekzA-5koiA:
undetectable		 6ekzA-5koiA:
16.94