SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kom'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5kom PUTATIVE FLUORIDE
ION TRANSPORTER CRCB
(Escherichia
coli) 		5 / 9 CYH A  74
LEU A  77
LEU A  18
THR A  70
ILE A  69
 None
 1.40A 1hzeA-5komA:
undetectable
1hzeB-5komA:
undetectable		 1hzeA-5komA:
25.66
1hzeB-5komA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5kom PUTATIVE FLUORIDE
ION TRANSPORTER CRCB
(Escherichia
coli) 		5 / 9 THR A  70
ILE A  69
CYH A  74
LEU A  77
LEU A  18
 None
 1.40A 1hzeA-5komA:
undetectable
1hzeB-5komA:
undetectable		 1hzeA-5komA:
25.66
1hzeB-5komA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5kom PUTATIVE FLUORIDE
ION TRANSPORTER CRCB
(Escherichia
coli) 		5 / 10 CYH A  74
LEU A  77
LEU A  18
THR A  70
ILE A  69
 None
 1.42A 1i18A-5komA:
undetectable
1i18B-5komA:
undetectable		 1i18A-5komA:
25.66
1i18B-5komA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5kom PUTATIVE FLUORIDE
ION TRANSPORTER CRCB
(Escherichia
coli) 		5 / 10 THR A  70
ILE A  69
CYH A  74
LEU A  77
LEU A  18
 None
 1.41A 1i18A-5komA:
undetectable
1i18B-5komA:
undetectable		 1i18A-5komA:
25.66
1i18B-5komA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 5kom PUTATIVE FLUORIDE
ION TRANSPORTER CRCB
(Escherichia
coli) 		5 / 12 GLY A  75
ALA A  44
ILE A  47
VAL A   8
PHE A  64
 NA  A 201 (-4.4A)
F  A 203 ( 4.3A)
None
None
None
 1.35A 1vq1A-5komA:
undetectable		 1vq1A-5komA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA502_1
(CHITINASE)		 5kom PUTATIVE FLUORIDE
ION TRANSPORTER CRCB
(Escherichia
coli) 		4 / 5 TRP A  65
GLY A  11
ALA A   7
PHE A  55
 None
 1.11A 3wqwA-5komA:
undetectable		 3wqwA-5komA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 5kom PUTATIVE FLUORIDE
ION TRANSPORTER CRCB
(Escherichia
coli) 		4 / 8 THR A  70
LEU A  73
ILE A  47
LEU A  77
 None
 0.91A 5g48A-5komA:
undetectable		 5g48A-5komA:
18.67