SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kov'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 5kov CAPSID POLYPROTEIN
VP90
PL-2 SCFV CHAIN
(Mamastrovirus
1;
Mus
musculus) 		4 / 6 GLY C1091
TYR C 100
ALA A 458
TYR C1032
 None
 0.96A 1dmaB-5kovC:
undetectable		 1dmaB-5kovC:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 5kov PL-2 SCFV CHAIN
(Mus
musculus) 		4 / 5 ARG C1024
ALA C1025
ASP C1070
GLY C1068
 None
 1.20A 1e7bA-5kovC:
undetectable		 1e7bA-5kovC:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_L_TRPL81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5kov CAPSID POLYPROTEIN
VP90
PL-2 SCFV CHAIN
(Mamastrovirus
1;
Mus
musculus) 		5 / 12 GLY C  49
HIS C  35
THR A 461
GLY C 101
SER A 463
 None
 1.00A 1utdL-5kovC:
undetectable
1utdM-5kovC:
undetectable		 1utdL-5kovC:
15.16
1utdM-5kovC:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_V_TRPV81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5kov CAPSID POLYPROTEIN
VP90
PL-2 SCFV CHAIN
(Mamastrovirus
1;
Mus
musculus) 		5 / 11 GLY C 101
SER A 463
GLY C  49
HIS C  35
THR A 461
 None
 0.94A 1utdL-5kovC:
undetectable
1utdV-5kovC:
undetectable		 1utdL-5kovC:
15.16
1utdV-5kovC:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 5kov PL-2 SCFV CHAIN
(Mus
musculus) 		4 / 6 VAL C  37
LEU C  48
PHE C  63
MET C  82
 None
 1.12A 1x8vA-5kovC:
undetectable		 1x8vA-5kovC:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5kov CAPSID POLYPROTEIN
VP90
PL-2 SCFV CHAIN
(Mamastrovirus
1;
Mus
musculus) 		4 / 5 TRP C  52
GLY C 101
ASN C 102
GLY A 460
 None
 0.67A 1zlqA-5kovC:
undetectable		 1zlqA-5kovC:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 5kov CAPSID POLYPROTEIN
VP90
PL-2 SCFV CHAIN
(Mamastrovirus
1;
Mus
musculus) 		3 / 3 ARG A 610
ASP A 465
ASP C  31
 None
 0.52A 2ejtA-5kovA:
undetectable		 2ejtA-5kovA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 5kov CAPSID POLYPROTEIN
VP90
(Mamastrovirus
1) 		3 / 3 TYR A 557
GLU A 561
ASP A 564
 None
 0.84A 3bxoA-5kovA:
undetectable		 3bxoA-5kovA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 5kov CAPSID POLYPROTEIN
VP90
(Mamastrovirus
1) 		3 / 3 TYR A 557
GLU A 561
ASP A 564
 None
 0.78A 3bxoB-5kovA:
undetectable		 3bxoB-5kovA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 5kov PL-2 SCFV CHAIN
(Mus
musculus) 		3 / 3 ILE C1083
SER C1012
SER C1014
 None
 0.50A 3iltH-5kovC:
undetectable		 3iltH-5kovC:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_B_KKKB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5kov CAPSID POLYPROTEIN
VP90
PL-2 SCFV CHAIN
(Mamastrovirus
1;
Mus
musculus) 		5 / 12 GLY C 101
ALA A 458
THR A 455
ILE A 479
MET A 511
 None
 1.45A 3ld6B-5kovC:
undetectable		 3ld6B-5kovC:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 5kov CAPSID POLYPROTEIN
VP90
(Mamastrovirus
1) 		3 / 3 GLN A 481
THR A 593
LEU A 571
 None
 0.67A 3ondB-5kovA:
undetectable		 3ondB-5kovA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 5kov PL-2 SCFV CHAIN
(Mus
musculus) 		4 / 4 LEU C1015
GLY C1016
LEU C1078
GLU C1079
 None
 1.08A 3tgvB-5kovC:
undetectable		 3tgvB-5kovC:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 5kov PL-2 SCFV CHAIN
(Mus
musculus) 		4 / 7 ASN C1034
LEU C1046
GLY C 101
TYR C  99
 None
 0.94A 4cp3A-5kovC:
undetectable
4cp3B-5kovC:
undetectable		 4cp3A-5kovC:
19.47
4cp3B-5kovC:
19.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M93_B_ACTB305_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN)		 5kov PL-2 SCFV CHAIN
(Mus
musculus) 		4 / 4 SER C  19
THR C  21
PHE C  79
LYS C  81
 None
 0.72A 4m93B-5kovC:
14.1		 4m93B-5kovC:
50.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 5kov CAPSID POLYPROTEIN
VP90
(Mamastrovirus
1) 		3 / 3 MET A 480
MET A 508
TYR A 590
 None
 0.77A 4p6xI-5kovA:
undetectable		 4p6xI-5kovA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 5kov PL-2 SCFV CHAIN
(Mus
musculus) 		5 / 12 GLY C1057
PHE C  27
ILE C  51
GLY C  33
HIS C1055
 None
 1.20A 5fsaB-5kovC:
undetectable		 5fsaB-5kovC:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 5kov PL-2 SCFV CHAIN
(Mus
musculus) 		5 / 12 GLY C  91
VAL C  34
GLY C  49
GLY C 110
VAL C1044
 None
 1.05A 5tuiB-5kovC:
undetectable		 5tuiB-5kovC:
19.32