SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kp7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 5kp7 CURD
(Moorea
producens) 		5 / 12 ALA A 124
ILE A  62
ARG A  65
LEU A  66
ILE A  74
 None
 1.04A 1d1gA-5kp7A:
undetectable		 1d1gA-5kp7A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 5kp7 CURD
(Moorea
producens) 		5 / 12 ALA A  16
PHE A 391
GLN A 389
SER A 374
TYR A  54
 None
 1.15A 1dlsA-5kp7A:
undetectable		 1dlsA-5kp7A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5kp7 CURD
(Moorea
producens) 		5 / 12 TYR A  54
LEU A 362
VAL A 394
VAL A 294
ALA A  43
 None
 1.13A 1q23H-5kp7A:
undetectable
1q23I-5kp7A:
undetectable		 1q23H-5kp7A:
19.29
1q23I-5kp7A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5kp7 CURD
(Moorea
producens) 		5 / 12 ALA A 124
ILE A  62
ARG A  65
LEU A  66
ILE A  74
 None
 0.99A 1rx2A-5kp7A:
undetectable		 1rx2A-5kp7A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 5kp7 CURD
(Moorea
producens) 		5 / 12 ALA A  16
PHE A 391
GLN A 389
SER A 374
TYR A  54
 None
 1.10A 1u72A-5kp7A:
undetectable		 1u72A-5kp7A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5kp7 CURD
(Moorea
producens) 		5 / 12 ALA A  43
VAL A  11
TYR A  54
GLY A 169
ILE A 297
 None
 0.96A 2dcfA-5kp7A:
undetectable		 2dcfA-5kp7A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 5kp7 CURD
(Moorea
producens) 		4 / 6 LEU A 121
TYR A 335
ILE A   6
GLY A 322
 None
 0.94A 2du8B-5kp7A:
undetectable		 2du8B-5kp7A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 5kp7 CURD
(Moorea
producens) 		3 / 3 PRO A 286
GLY A 313
TYR A 246
 None
 0.72A 2vouB-5kp7A:
undetectable		 2vouB-5kp7A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_G_RBFG200_1
(DODECIN)		 5kp7 CURD
(Moorea
producens) 		4 / 8 HIS A 230
TYR A 115
THR A 118
GLN A 122
 None
 1.37A 2vxaF-5kp7A:
0.7
2vxaG-5kp7A:
0.7
2vxaI-5kp7A:
0.7		 2vxaF-5kp7A:
11.03
2vxaG-5kp7A:
11.03
2vxaI-5kp7A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 5kp7 CURD
(Moorea
producens) 		5 / 12 LEU A 121
LEU A 176
ARG A  65
PHE A 303
LEU A 306
 None
 1.36A 2w8yA-5kp7A:
undetectable		 2w8yA-5kp7A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5kp7 CURD
(Moorea
producens) 		4 / 5 TYR A 335
PHE A 303
VAL A 140
TYR A 115
 None
 1.46A 2x7hA-5kp7A:
undetectable		 2x7hA-5kp7A:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5kp7 CURD
(Moorea
producens) 		4 / 5 TYR A 335
PHE A 303
VAL A 140
TYR A 115
 None
 1.47A 2x7hB-5kp7A:
undetectable		 2x7hB-5kp7A:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5kp7 CURD
(Moorea
producens) 		4 / 8 ALA A  43
TYR A  54
GLY A 169
ILE A 297
 None
 0.77A 2zm9A-5kp7A:
undetectable		 2zm9A-5kp7A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5kp7 CURD
(Moorea
producens) 		5 / 12 ALA A  43
VAL A  11
TYR A  54
GLY A 169
ILE A 297
 None
 1.05A 3a65A-5kp7A:
undetectable		 3a65A-5kp7A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		 5kp7 CURD
(Moorea
producens) 		5 / 9 VAL A 294
GLY A 169
ILE A 145
TYR A  54
GLY A  13
 None
 1.13A 3csjB-5kp7A:
undetectable		 3csjB-5kp7A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		 5kp7 CURD
(Moorea
producens) 		5 / 9 VAL A 294
GLY A 169
ILE A 145
TYR A  54
GLY A  14
 None
 1.34A 3csjB-5kp7A:
undetectable		 3csjB-5kp7A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		 5kp7 CURD
(Moorea
producens) 		5 / 9 ILE A  63
ILE A  74
LYS A 137
LEU A 176
GLU A   7
 None
 1.37A 3f78A-5kp7A:
undetectable		 3f78A-5kp7A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_B_ICFB2_1
(INTEGRIN ALPHA-L)		 5kp7 CURD
(Moorea
producens) 		5 / 9 ILE A  63
ILE A  74
LYS A 137
LEU A 176
GLU A   7
 None
 1.35A 3f78B-5kp7A:
undetectable		 3f78B-5kp7A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 5kp7 CURD
(Moorea
producens) 		5 / 12 GLY A 117
GLY A 327
SER A 325
PHE A 324
ALA A 227
 None
 0.99A 3keeA-5kp7A:
undetectable		 3keeA-5kp7A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 5kp7 CURD
(Moorea
producens) 		5 / 12 GLY A 117
GLY A 327
SER A 325
PHE A 324
ALA A 227
 None
 0.95A 3keeB-5kp7A:
undetectable		 3keeB-5kp7A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 5kp7 CURD
(Moorea
producens) 		5 / 12 GLY A 117
GLY A 327
SER A 325
PHE A 324
ALA A 227
 None
 0.94A 3keeC-5kp7A:
undetectable		 3keeC-5kp7A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 5kp7 CURD
(Moorea
producens) 		5 / 12 GLY A 117
GLY A 327
SER A 325
PHE A 324
ALA A 227
 None
 0.96A 3keeD-5kp7A:
undetectable		 3keeD-5kp7A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5kp7 CURD
(Moorea
producens) 		5 / 12 TYR A  12
GLY A 171
GLY A 299
ALA A 300
PHE A 303
 None
 0.94A 3sudB-5kp7A:
undetectable		 3sudB-5kp7A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5kp7 CURD
(Moorea
producens) 		5 / 12 GLY A 117
GLY A 327
SER A 325
PHE A 324
ALA A 227
 None
 1.00A 3sueA-5kp7A:
undetectable		 3sueA-5kp7A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5kp7 CURD
(Moorea
producens) 		5 / 12 GLY A 117
GLY A 327
SER A 325
PHE A 324
ALA A 227
 None
 1.01A 3sueB-5kp7A:
undetectable		 3sueB-5kp7A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5kp7 CURD
(Moorea
producens) 		5 / 12 GLY A 117
GLY A 327
SER A 325
PHE A 324
ALA A 227
 None
 0.94A 3sueC-5kp7A:
undetectable		 3sueC-5kp7A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5kp7 CURD
(Moorea
producens) 		5 / 12 GLY A 117
GLY A 327
SER A 325
PHE A 324
ALA A 227
 None
 0.98A 3sufA-5kp7A:
undetectable		 3sufA-5kp7A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5kp7 CURD
(Moorea
producens) 		5 / 12 GLY A 117
GLY A 327
SER A 325
PHE A 324
ALA A 227
 None
 0.99A 3sufB-5kp7A:
undetectable		 3sufB-5kp7A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5kp7 CURD
(Moorea
producens) 		5 / 11 GLY A 117
GLY A 327
SER A 325
PHE A 324
ALA A 227
 None
 1.03A 3sufC-5kp7A:
undetectable		 3sufC-5kp7A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 5kp7 CURD
(Moorea
producens) 		5 / 9 ASN A 312
GLY A 313
PHE A 315
SER A 305
GLY A 287
 None
 1.30A 3ztvA-5kp7A:
undetectable		 3ztvA-5kp7A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5kp7 CURD
(Moorea
producens) 		5 / 12 ALA A 124
ILE A  62
ARG A  65
LEU A  66
ILE A  74
 None
 0.97A 4nx6A-5kp7A:
undetectable		 4nx6A-5kp7A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 5kp7 CURD
(Moorea
producens) 		4 / 5 LEU A 406
ASP A  50
TYR A 388
LEU A 386
 None
 1.23A 4wozF-5kp7A:
undetectable
4wozH-5kp7A:
undetectable		 4wozF-5kp7A:
22.17
4wozH-5kp7A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5kp7 CURD
(Moorea
producens) 		4 / 5 TYR A 335
GLY A 120
TYR A 115
GLY A 327
 None
 0.86A 5ayfA-5kp7A:
undetectable		 5ayfA-5kp7A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 5kp7 CURD
(Moorea
producens) 		5 / 12 ALA A 170
GLY A 169
SER A 168
LYS A  40
LEU A  23
 None
 1.18A 5nwuA-5kp7A:
undetectable		 5nwuA-5kp7A:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5kp7 CURD
(Moorea
producens) 		4 / 5 TYR A 367
VAL A  44
PRO A  47
ALA A  16
 None
 1.02A 5otrA-5kp7A:
undetectable		 5otrA-5kp7A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5kp7 CURD
(Moorea
producens) 		6 / 12 LEU A 127
ALA A 138
LEU A 175
GLY A 135
PRO A 134
GLN A 131
 None
 1.22A 5vcvA-5kp7A:
undetectable		 5vcvA-5kp7A:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5kp7 CURD
(Moorea
producens) 		4 / 5 LEU A  23
LYS A  22
ALA A  24
LEU A  29
 None
 0.85A 5vkqA-5kp7A:
undetectable
5vkqD-5kp7A:
undetectable		 5vkqA-5kp7A:
13.41
5vkqD-5kp7A:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5kp7 CURD
(Moorea
producens) 		4 / 5 LEU A  23
LYS A  22
ALA A  24
LEU A  29
 None
 0.84A 5vkqA-5kp7A:
undetectable
5vkqB-5kp7A:
undetectable		 5vkqA-5kp7A:
13.41
5vkqB-5kp7A:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5kp7 CURD
(Moorea
producens) 		4 / 5 LEU A  23
LYS A  22
ALA A  24
LEU A  29
 None
 0.83A 5vkqB-5kp7A:
undetectable
5vkqC-5kp7A:
undetectable		 5vkqB-5kp7A:
13.41
5vkqC-5kp7A:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5kp7 CURD
(Moorea
producens) 		4 / 5 LEU A  23
LYS A  22
ALA A  24
LEU A  29
 None
 0.84A 5vkqC-5kp7A:
undetectable
5vkqD-5kp7A:
undetectable		 5vkqC-5kp7A:
13.41
5vkqD-5kp7A:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 5kp7 CURD
(Moorea
producens) 		4 / 6 PHE A 391
PRO A 392
GLY A 393
LYS A 397
 None
 0.76A 5x24A-5kp7A:
0.0		 5x24A-5kp7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 5kp7 CURD
(Moorea
producens) 		3 / 3 VAL A 394
TYR A 360
GLU A  49
 None
 0.94A 5zmqD-5kp7A:
undetectable
5zmqE-5kp7A:
undetectable		 5zmqD-5kp7A:
17.15
5zmqE-5kp7A:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5kp7 CURD
(Moorea
producens) 		5 / 12 VAL A  44
GLY A 169
SER A 168
TRP A 161
VAL A 150
 None
 1.45A 6a94A-5kp7A:
undetectable		 6a94A-5kp7A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5kp7 CURD
(Moorea
producens) 		3 / 3 ARG A 283
LEU A 247
PHE A 324
 None
 0.76A 6nknP-5kp7A:
undetectable		 6nknP-5kp7A:
20.58