SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kpg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
3 / 3 SER A  97
THR A 158
GLN A 163
SAH  A 401 (-2.5A)
None
SAH  A 401 (-3.5A)
0.43A 2fk8A-5kpgA:
26.7
2fk8A-5kpgA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
5 / 12 ASP A 133
LEU A 134
GLY A 135
GLY A 137
LEU A 203
SAH  A 401 ( 4.9A)
None
SAH  A 401 (-3.7A)
SAH  A 401 ( 3.8A)
SAH  A 401 (-4.5A)
0.78A 2nxeB-5kpgA:
12.5
2nxeB-5kpgA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PXC_A_SAMA500_0
(GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)])
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
5 / 12 GLY A 135
GLY A 137
THR A 158
ASP A 185
VAL A 186
SAH  A 401 (-3.7A)
SAH  A 401 ( 3.8A)
None
SAH  A 401 (-3.5A)
SAH  A 401 (-3.8A)
0.60A 2pxcA-5kpgA:
7.6
2pxcA-5kpgA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
5 / 12 GLY A 135
GLY A 137
ASP A 185
VAL A 186
VAL A 201
SAH  A 401 (-3.7A)
SAH  A 401 ( 3.8A)
SAH  A 401 (-3.5A)
SAH  A 401 (-3.8A)
SAH  A 401 (-4.3A)
0.48A 2qe6B-5kpgA:
10.6
2qe6B-5kpgA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_A_SAMA1248_0
(NON-STRUCTURAL
PROTEIN 5)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
5 / 12 GLY A 135
GLY A 137
ASP A 185
VAL A 186
THR A 187
SAH  A 401 (-3.7A)
SAH  A 401 ( 3.8A)
SAH  A 401 (-3.5A)
SAH  A 401 (-3.8A)
SAH  A 401 ( 3.9A)
0.44A 2wa2A-5kpgA:
8.1
2wa2A-5kpgA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_A_SAMA1248_0
(NON-STRUCTURAL
PROTEIN 5)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
5 / 12 GLY A 135
GLY A 137
THR A 158
ASP A 185
THR A 187
SAH  A 401 (-3.7A)
SAH  A 401 ( 3.8A)
None
SAH  A 401 (-3.5A)
SAH  A 401 ( 3.9A)
0.56A 2wa2A-5kpgA:
8.1
2wa2A-5kpgA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_0
(NON-STRUCTURAL
PROTEIN 5)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
5 / 12 GLY A 135
GLY A 137
THR A 158
VAL A 186
THR A 187
SAH  A 401 (-3.7A)
SAH  A 401 ( 3.8A)
None
SAH  A 401 (-3.8A)
SAH  A 401 ( 3.9A)
0.55A 2wa2B-5kpgA:
8.5
2wa2B-5kpgA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_2
(ALPHA-1-ACID
GLYCOPROTEIN 2)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
4 / 4 VAL A 261
ARG A  39
HIS A 234
PHE A  58
None
1.50A 3apwA-5kpgA:
undetectable
3apwA-5kpgA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
5 / 12 GLY A 135
GLY A 137
THR A 158
ASP A 185
VAL A 186
SAH  A 401 (-3.7A)
SAH  A 401 ( 3.8A)
None
SAH  A 401 (-3.5A)
SAH  A 401 (-3.8A)
0.55A 3gczA-5kpgA:
8.2
3gczA-5kpgA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
5 / 12 GLY A 135
GLY A 137
GLY A 139
ASP A 185
LEU A 203
SAH  A 401 (-3.7A)
SAH  A 401 ( 3.8A)
None
SAH  A 401 (-3.5A)
SAH  A 401 (-4.5A)
0.86A 3ihtA-5kpgA:
7.9
3ihtA-5kpgA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_A_SAMA263_0
(NON-STRUCTURAL
PROTEIN 5)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
5 / 12 GLY A 135
GLY A 137
THR A 158
ASP A 185
VAL A 186
SAH  A 401 (-3.7A)
SAH  A 401 ( 3.8A)
None
SAH  A 401 (-3.5A)
SAH  A 401 (-3.8A)
0.58A 3p97A-5kpgA:
7.8
3p97A-5kpgA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_C_SAMC263_0
(NON-STRUCTURAL
PROTEIN 5)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
5 / 12 GLY A 135
GLY A 137
THR A 158
ASP A 185
VAL A 186
SAH  A 401 (-3.7A)
SAH  A 401 ( 3.8A)
None
SAH  A 401 (-3.5A)
SAH  A 401 (-3.8A)
0.57A 3p97C-5kpgA:
7.5
3p97C-5kpgA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_A_SAMA1263_0
(NON-STRUCTURAL
PROTEIN 5)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
5 / 12 GLY A 135
GLY A 137
THR A 158
ASP A 185
VAL A 186
SAH  A 401 (-3.7A)
SAH  A 401 ( 3.8A)
None
SAH  A 401 (-3.5A)
SAH  A 401 (-3.8A)
0.58A 4ctjA-5kpgA:
8.3
4ctjA-5kpgA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_A_SAMA1263_0
(POLYPROTEIN)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
5 / 12 GLY A 135
GLY A 137
THR A 158
ASP A 185
VAL A 186
SAH  A 401 (-3.7A)
SAH  A 401 ( 3.8A)
None
SAH  A 401 (-3.5A)
SAH  A 401 (-3.8A)
0.57A 4ctkA-5kpgA:
7.5
4ctkA-5kpgA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_2
(SERUM ALBUMIN)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
4 / 4 VAL A  23
GLU A  19
ASP A 300
LYS A 307
None
1.13A 4l9qA-5kpgA:
0.7
4l9qA-5kpgA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
5 / 9 LEU A  62
LEU A 214
GLN A 272
PHE A 271
TYR A 270
None
1.39A 4ltwA-5kpgA:
undetectable
4ltwA-5kpgA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
5 / 9 ALA A 200
ILE A 157
GLY A 156
ILE A 221
VAL A 217
None
1.15A 4nptA-5kpgA:
undetectable
4nptA-5kpgA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
5 / 12 GLY A 135
GLY A 137
SER A 140
SER A 160
HIS A 206
SAH  A 401 (-3.7A)
SAH  A 401 ( 3.8A)
SAH  A 401 (-3.3A)
None
SAH  A 401 (-3.9A)
0.91A 4qdjA-5kpgA:
14.2
4qdjA-5kpgA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
4 / 6 CYH A 233
GLU A 345
GLY A 343
GLY A 285
None
0.98A 5a06D-5kpgA:
2.8
5a06D-5kpgA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_A_SAMA301_0
(GENOME POLYPROTEIN)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
5 / 12 GLY A 135
GLY A 137
THR A 158
ASP A 185
VAL A 186
SAH  A 401 (-3.7A)
SAH  A 401 ( 3.8A)
None
SAH  A 401 (-3.5A)
SAH  A 401 (-3.8A)
0.57A 5e9qA-5kpgA:
7.7
5e9qA-5kpgA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_C_SAMC4000_0
(GENOME POLYPROTEIN)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
5 / 12 GLY A 135
GLY A 137
THR A 158
ASP A 185
VAL A 186
SAH  A 401 (-3.7A)
SAH  A 401 ( 3.8A)
None
SAH  A 401 (-3.5A)
SAH  A 401 (-3.8A)
0.59A 5e9qC-5kpgA:
7.0
5e9qC-5kpgA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_C_SAMC4000_0
(GENOME POLYPROTEIN)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
5 / 12 GLY A 135
GLY A 137
THR A 158
ASP A 185
VAL A 186
SAH  A 401 (-3.7A)
SAH  A 401 ( 3.8A)
None
SAH  A 401 (-3.5A)
SAH  A 401 (-3.8A)
0.55A 5ec8C-5kpgA:
7.6
5ec8C-5kpgA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_A_SAMA301_0
(RNA-DIRECTED RNA
POLYMERASE NS5)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
5 / 12 GLY A 135
GLY A 137
THR A 158
ASP A 185
VAL A 186
SAH  A 401 (-3.7A)
SAH  A 401 ( 3.8A)
None
SAH  A 401 (-3.5A)
SAH  A 401 (-3.8A)
0.58A 5ehgA-5kpgA:
7.8
5ehgA-5kpgA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_A_SAMA4001_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
5 / 12 GLY A 135
GLY A 137
THR A 158
ASP A 185
VAL A 186
SAH  A 401 (-3.7A)
SAH  A 401 ( 3.8A)
None
SAH  A 401 (-3.5A)
SAH  A 401 (-3.8A)
0.58A 5ehiA-5kpgA:
7.6
5ehiA-5kpgA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_C_SAMC4000_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
5 / 12 GLY A 135
GLY A 137
THR A 158
ASP A 185
VAL A 186
SAH  A 401 (-3.7A)
SAH  A 401 ( 3.8A)
None
SAH  A 401 (-3.5A)
SAH  A 401 (-3.8A)
0.57A 5ehiC-5kpgA:
7.4
5ehiC-5kpgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_A_SAMA301_0
(GENOME POLYPROTEIN)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
5 / 12 GLY A 135
GLY A 137
THR A 158
ASP A 185
VAL A 186
SAH  A 401 (-3.7A)
SAH  A 401 ( 3.8A)
None
SAH  A 401 (-3.5A)
SAH  A 401 (-3.8A)
0.58A 5eifA-5kpgA:
7.6
5eifA-5kpgA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_C_SAMC4000_0
(GENOME POLYPROTEIN)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
5 / 12 GLY A 135
GLY A 137
THR A 158
ASP A 185
VAL A 186
SAH  A 401 (-3.7A)
SAH  A 401 ( 3.8A)
None
SAH  A 401 (-3.5A)
SAH  A 401 (-3.8A)
0.57A 5eifC-5kpgA:
undetectable
5eifC-5kpgA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
5 / 12 GLY A 135
GLY A 137
THR A 158
ASP A 185
VAL A 186
SAH  A 401 (-3.7A)
SAH  A 401 ( 3.8A)
None
SAH  A 401 (-3.5A)
SAH  A 401 (-3.8A)
0.59A 5eiwA-5kpgA:
7.6
5eiwA-5kpgA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
5 / 12 GLY A 135
GLY A 137
THR A 158
ASP A 185
VAL A 186
SAH  A 401 (-3.7A)
SAH  A 401 ( 3.8A)
None
SAH  A 401 (-3.5A)
SAH  A 401 (-3.8A)
0.60A 5eiwC-5kpgA:
7.8
5eiwC-5kpgA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_A_SAMA301_0
(NS5
METHYLTRANSFERASE)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
5 / 12 GLY A 135
GLY A 137
THR A 158
ASP A 185
VAL A 186
SAH  A 401 (-3.7A)
SAH  A 401 ( 3.8A)
None
SAH  A 401 (-3.5A)
SAH  A 401 (-3.8A)
0.55A 5ekxA-5kpgA:
7.5
5ekxA-5kpgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKM_A_SAMA311_0
(NS5 METHYL
TRANSFERASE)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
5 / 12 GLY A 135
GLY A 137
THR A 158
ASP A 185
VAL A 186
SAH  A 401 (-3.7A)
SAH  A 401 ( 3.8A)
None
SAH  A 401 (-3.5A)
SAH  A 401 (-3.8A)
0.60A 5ikmA-5kpgA:
8.5
5ikmA-5kpgA:
18.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
12 / 12 PHE A  96
GLY A 137
SER A 140
ASN A 159
GLN A 163
ASP A 185
VAL A 186
THR A 187
VAL A 201
ALA A 202
LEU A 203
HIS A 206
None
SAH  A 401 ( 3.8A)
SAH  A 401 (-3.3A)
SAH  A 401 (-3.4A)
SAH  A 401 (-3.5A)
SAH  A 401 (-3.5A)
SAH  A 401 (-3.8A)
SAH  A 401 ( 3.9A)
SAH  A 401 (-4.3A)
SAH  A 401 (-3.9A)
SAH  A 401 (-4.5A)
SAH  A 401 (-3.9A)
0.26A 5kocA-5kpgA:
54.7
5kocA-5kpgA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
12 / 12 PHE A  96
SER A  97
GLY A 135
GLY A 137
SER A 140
THR A 158
ASN A 159
GLN A 163
VAL A 186
VAL A 201
LEU A 203
HIS A 206
None
SAH  A 401 (-2.5A)
SAH  A 401 (-3.7A)
SAH  A 401 ( 3.8A)
SAH  A 401 (-3.3A)
None
SAH  A 401 (-3.4A)
SAH  A 401 (-3.5A)
SAH  A 401 (-3.8A)
SAH  A 401 (-4.3A)
SAH  A 401 (-4.5A)
SAH  A 401 (-3.9A)
0.26A 5kocB-5kpgA:
53.7
5kocB-5kpgA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KPC_A_SAMA401_1
(PAVINE
N-METHYLTRANSFERASE)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
5 / 5 PHE A  96
SER A  97
ASN A 159
GLN A 163
ASP A 185
None
SAH  A 401 (-2.5A)
SAH  A 401 (-3.4A)
SAH  A 401 (-3.5A)
SAH  A 401 (-3.5A)
0.51A 5kpcA-5kpgA:
53.7
5kpcA-5kpgA:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
11 / 12 LYS A  95
PHE A  96
SER A  97
GLY A 135
GLY A 137
ASN A 159
GLN A 163
ASP A 185
VAL A 186
THR A 187
ALA A 202
SAH  A 401 ( 4.4A)
None
SAH  A 401 (-2.5A)
SAH  A 401 (-3.7A)
SAH  A 401 ( 3.8A)
SAH  A 401 (-3.4A)
SAH  A 401 (-3.5A)
SAH  A 401 (-3.5A)
SAH  A 401 (-3.8A)
SAH  A 401 ( 3.9A)
SAH  A 401 (-3.9A)
0.36A 5kpcB-5kpgA:
51.2
5kpcB-5kpgA:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
9 / 12 LYS A  95
PHE A  96
SER A  97
GLY A 135
GLY A 137
ASN A 159
SER A 160
GLN A 163
VAL A 186
SAH  A 401 ( 4.4A)
None
SAH  A 401 (-2.5A)
SAH  A 401 (-3.7A)
SAH  A 401 ( 3.8A)
SAH  A 401 (-3.4A)
None
SAH  A 401 (-3.5A)
SAH  A 401 (-3.8A)
0.59A 5kpcB-5kpgA:
51.2
5kpcB-5kpgA:
99.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQR_A_SAMA301_0
(METHYLTRANSFERASE)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
5 / 12 GLY A 135
GLY A 137
THR A 158
ASP A 185
VAL A 186
SAH  A 401 (-3.7A)
SAH  A 401 ( 3.8A)
None
SAH  A 401 (-3.5A)
SAH  A 401 (-3.8A)
0.57A 5kqrA-5kpgA:
8.2
5kqrA-5kpgA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQS_A_SAMA307_0
(GENOME POLYPROTEIN)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
5 / 12 GLY A 135
GLY A 137
THR A 158
ASP A 185
VAL A 186
SAH  A 401 (-3.7A)
SAH  A 401 ( 3.8A)
None
SAH  A 401 (-3.5A)
SAH  A 401 (-3.8A)
0.56A 5kqsA-5kpgA:
7.4
5kqsA-5kpgA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5B_A_SAMA1001_0
(NS5
METHYLTRANSFERASE)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
5 / 12 GLY A 135
GLY A 137
THR A 158
ASP A 185
VAL A 186
SAH  A 401 (-3.7A)
SAH  A 401 ( 3.8A)
None
SAH  A 401 (-3.5A)
SAH  A 401 (-3.8A)
0.59A 5m5bA-5kpgA:
8.2
5m5bA-5kpgA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_A_SAMA301_0
(NS5)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
5 / 12 GLY A 135
GLY A 137
THR A 158
ASP A 185
VAL A 186
SAH  A 401 (-3.7A)
SAH  A 401 ( 3.8A)
None
SAH  A 401 (-3.5A)
SAH  A 401 (-3.8A)
0.58A 5njvA-5kpgA:
8.0
5njvA-5kpgA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_B_SAMB301_0
(NS5)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
5 / 12 GLY A 135
GLY A 137
THR A 158
ASP A 185
VAL A 186
SAH  A 401 (-3.7A)
SAH  A 401 ( 3.8A)
None
SAH  A 401 (-3.5A)
SAH  A 401 (-3.8A)
0.57A 5njvB-5kpgA:
7.7
5njvB-5kpgA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_D_SAMD301_0
(NS5)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
5 / 12 GLY A 135
GLY A 137
THR A 158
ASP A 185
VAL A 186
SAH  A 401 (-3.7A)
SAH  A 401 ( 3.8A)
None
SAH  A 401 (-3.5A)
SAH  A 401 (-3.8A)
0.61A 5njvD-5kpgA:
7.3
5njvD-5kpgA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
3 / 3 LYS A 293
TRP A 295
SER A 335
None
1.26A 5nwwA-5kpgA:
undetectable
5nwwA-5kpgA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3C_A_AMHA402_1
(QUEUINE
TRNA-RIBOSYLTRANSFER
ASE)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
5 / 9 ASP A 196
GLN A 129
GLY A 128
ALA A 146
VAL A 145
None
1.46A 5v3cA-5kpgA:
undetectable
5v3cA-5kpgA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_B_SAMB601_0
(NS5
METHYLTRANSFERASE)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
5 / 12 GLY A 135
GLY A 137
THR A 158
ASP A 185
VAL A 186
SAH  A 401 (-3.7A)
SAH  A 401 ( 3.8A)
None
SAH  A 401 (-3.5A)
SAH  A 401 (-3.8A)
0.50A 5wz1B-5kpgA:
7.9
5wz1B-5kpgA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_A_SAMA601_0
(NS5 MTASE)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
5 / 12 GLY A 135
GLY A 137
THR A 158
ASP A 185
VAL A 186
SAH  A 401 (-3.7A)
SAH  A 401 ( 3.8A)
None
SAH  A 401 (-3.5A)
SAH  A 401 (-3.8A)
0.53A 5wz2A-5kpgA:
7.1
5wz2A-5kpgA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_B_SAMB601_0
(NS5 MTASE)
5kpg PAVINE
N-METHYLTRANSFERASE

(Thalictrum
flavum)
5 / 12 GLY A 135
GLY A 137
THR A 158
ASP A 185
VAL A 186
SAH  A 401 (-3.7A)
SAH  A 401 ( 3.8A)
None
SAH  A 401 (-3.5A)
SAH  A 401 (-3.8A)
0.51A 5wz2B-5kpgA:
8.3
5wz2B-5kpgA:
22.72