SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kqc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5kqc PEPTIDASE M23
(Staphylococcus
aureus) 		5 / 12 HIS A 159
ASP A  80
HIS A  76
LEU A 124
GLY A 106
 ZN  A 201 (-3.2A)
ZN  A 201 (-1.5A)
ZN  A 201 (-3.7A)
None
None
 1.45A 1d4fB-5kqcA:
undetectable		 1d4fB-5kqcA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		 5kqc PEPTIDASE M23
(Staphylococcus
aureus) 		5 / 12 HIS A 157
HIS A 125
GLY A 106
ASP A  80
HIS A 159
 None
None
None
ZN  A 201 (-1.5A)
ZN  A 201 (-3.2A)
 1.19A 1t69A-5kqcA:
undetectable		 1t69A-5kqcA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_D_ACTD5901_0
(PYRANOSE OXIDASE)		 5kqc PEPTIDASE M23
(Staphylococcus
aureus) 		4 / 6 THR A  93
GLN A 121
PHE A 178
PHE A 160
 None
 1.13A 1tt0D-5kqcA:
undetectable		 1tt0D-5kqcA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5kqc PEPTIDASE M23
(Staphylococcus
aureus) 		5 / 12 HIS A 159
ASP A  80
HIS A  76
LEU A 124
GLY A 106
 ZN  A 201 (-3.2A)
ZN  A 201 (-1.5A)
ZN  A 201 (-3.7A)
None
None
 1.48A 2zj0D-5kqcA:
undetectable		 2zj0D-5kqcA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 5kqc PEPTIDASE M23
(Staphylococcus
aureus) 		4 / 5 HIS A 157
HIS A 125
ASP A  80
HIS A 159
 None
None
ZN  A 201 (-1.5A)
ZN  A 201 (-3.2A)
 1.03A 3c0zA-5kqcA:
undetectable		 3c0zA-5kqcA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 5kqc PEPTIDASE M23
(Staphylococcus
aureus) 		4 / 6 HIS A 157
HIS A 125
ASP A  80
HIS A 159
 None
None
ZN  A 201 (-1.5A)
ZN  A 201 (-3.2A)
 1.03A 3c0zC-5kqcA:
undetectable		 3c0zC-5kqcA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5kqc PEPTIDASE M23
(Staphylococcus
aureus) 		4 / 6 SER A 146
ASP A 127
ILE A  89
THR A 149
 None
 1.01A 4acbC-5kqcA:
undetectable		 4acbC-5kqcA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 5kqc PEPTIDASE M23
(Staphylococcus
aureus) 		5 / 12 HIS A 157
HIS A 125
GLY A 106
ASP A  80
HIS A 159
 None
None
None
ZN  A 201 (-1.5A)
ZN  A 201 (-3.2A)
 1.19A 4bz6C-5kqcA:
undetectable		 4bz6C-5kqcA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		 5kqc PEPTIDASE M23
(Staphylococcus
aureus) 		5 / 12 HIS A 157
HIS A 125
GLY A 106
ASP A  80
HIS A 159
 None
None
None
ZN  A 201 (-1.5A)
ZN  A 201 (-3.2A)
 1.18A 4lxzA-5kqcA:
undetectable		 4lxzA-5kqcA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 5kqc PEPTIDASE M23
(Staphylococcus
aureus) 		5 / 12 HIS A 157
HIS A 125
GLY A 106
ASP A  80
HIS A 159
 None
None
None
ZN  A 201 (-1.5A)
ZN  A 201 (-3.2A)
 1.16A 4lxzC-5kqcA:
undetectable		 4lxzC-5kqcA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 5kqc PEPTIDASE M23
(Staphylococcus
aureus) 		5 / 12 HIS A 157
HIS A 125
GLY A 106
ASP A  80
HIS A 159
 None
None
None
ZN  A 201 (-1.5A)
ZN  A 201 (-3.2A)
 1.16A 4qa2A-5kqcA:
undetectable		 4qa2A-5kqcA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 5kqc PEPTIDASE M23
(Staphylococcus
aureus) 		5 / 12 HIS A 157
HIS A 125
GLY A 106
ASP A  80
HIS A 159
 None
None
None
ZN  A 201 (-1.5A)
ZN  A 201 (-3.2A)
 1.21A 4qa2B-5kqcA:
undetectable		 4qa2B-5kqcA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 5kqc PEPTIDASE M23
(Staphylococcus
aureus) 		5 / 12 HIS A 157
HIS A 125
GLY A 106
ASP A  80
HIS A 159
 None
None
None
ZN  A 201 (-1.5A)
ZN  A 201 (-3.2A)
 1.23A 5eeiA-5kqcA:
undetectable		 5eeiA-5kqcA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 5kqc PEPTIDASE M23
(Staphylococcus
aureus) 		5 / 12 HIS A 157
HIS A 125
GLY A 106
ASP A  80
HIS A 159
 None
None
None
ZN  A 201 (-1.5A)
ZN  A 201 (-3.2A)
 1.21A 5eeiB-5kqcA:
undetectable		 5eeiB-5kqcA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5kqc PEPTIDASE M23
(Staphylococcus
aureus) 		5 / 12 HIS A 159
ASP A  80
HIS A  76
LEU A 124
GLY A 106
 ZN  A 201 (-3.2A)
ZN  A 201 (-1.5A)
ZN  A 201 (-3.7A)
None
None
 1.50A 5hm8A-5kqcA:
undetectable		 5hm8A-5kqcA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5kqc PEPTIDASE M23
(Staphylococcus
aureus) 		5 / 12 HIS A 159
ASP A  80
HIS A  76
LEU A 124
GLY A 106
 ZN  A 201 (-3.2A)
ZN  A 201 (-1.5A)
ZN  A 201 (-3.7A)
None
None
 1.49A 5hm8B-5kqcA:
undetectable		 5hm8B-5kqcA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5kqc PEPTIDASE M23
(Staphylococcus
aureus) 		5 / 12 HIS A 159
ASP A  80
HIS A  76
LEU A 124
GLY A 106
 ZN  A 201 (-3.2A)
ZN  A 201 (-1.5A)
ZN  A 201 (-3.7A)
None
None
 1.49A 5hm8C-5kqcA:
undetectable		 5hm8C-5kqcA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5kqc PEPTIDASE M23
(Staphylococcus
aureus) 		5 / 12 HIS A 159
ASP A  80
HIS A  76
LEU A 124
GLY A 106
 ZN  A 201 (-3.2A)
ZN  A 201 (-1.5A)
ZN  A 201 (-3.7A)
None
None
 1.50A 5hm8D-5kqcA:
undetectable		 5hm8D-5kqcA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5kqc PEPTIDASE M23
(Staphylococcus
aureus) 		5 / 12 HIS A 159
ASP A  80
HIS A  76
LEU A 124
GLY A 106
 ZN  A 201 (-3.2A)
ZN  A 201 (-1.5A)
ZN  A 201 (-3.7A)
None
None
 1.49A 5hm8E-5kqcA:
undetectable		 5hm8E-5kqcA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5kqc PEPTIDASE M23
(Staphylococcus
aureus) 		5 / 12 HIS A 159
ASP A  80
HIS A  76
LEU A 124
GLY A 106
 ZN  A 201 (-3.2A)
ZN  A 201 (-1.5A)
ZN  A 201 (-3.7A)
None
None
 1.50A 5hm8F-5kqcA:
undetectable		 5hm8F-5kqcA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5kqc PEPTIDASE M23
(Staphylococcus
aureus) 		5 / 12 HIS A 159
ASP A  80
HIS A  76
LEU A 124
GLY A 106
 ZN  A 201 (-3.2A)
ZN  A 201 (-1.5A)
ZN  A 201 (-3.7A)
None
None
 1.50A 5hm8G-5kqcA:
undetectable		 5hm8G-5kqcA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5kqc PEPTIDASE M23
(Staphylococcus
aureus) 		5 / 12 HIS A 159
ASP A  80
HIS A  76
LEU A 124
GLY A 106
 ZN  A 201 (-3.2A)
ZN  A 201 (-1.5A)
ZN  A 201 (-3.7A)
None
None
 1.49A 5hm8H-5kqcA:
undetectable		 5hm8H-5kqcA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 5kqc PEPTIDASE M23
(Staphylococcus
aureus) 		4 / 7 HIS A  76
HIS A 159
HIS A 125
HIS A 157
 ZN  A 201 (-3.7A)
ZN  A 201 (-3.2A)
None
None
 0.92A 5i3bA-5kqcA:
undetectable		 5i3bA-5kqcA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 5kqc PEPTIDASE M23
(Staphylococcus
aureus) 		4 / 6 ILE A 142
GLY A  95
ASN A  94
ILE A 143
 None
 1.00A 5j4nB-5kqcA:
undetectable		 5j4nB-5kqcA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5kqc PEPTIDASE M23
(Staphylococcus
aureus) 		5 / 12 ILE A 143
TYR A 123
PHE A  81
GLY A 140
LEU A 182
 None
 1.04A 5v5zA-5kqcA:
undetectable		 5v5zA-5kqcA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 5kqc PEPTIDASE M23
(Staphylococcus
aureus) 		4 / 5 TYR A  67
GLY A  74
HIS A  76
ASP A  80
 None
None
ZN  A 201 (-3.7A)
ZN  A 201 (-1.5A)
 1.19A 6gh9A-5kqcA:
undetectable		 6gh9A-5kqcA:
20.00