SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kqv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5kqv INSULIN
RECEPTOR,INSULIN
RECEPTOR
(Homo
sapiens) 		5 / 12 LEU E 385
PHE E 382
LEU E 419
ILE E 336
SER E 446
 None
 1.22A 2pnjB-5kqvE:
undetectable		 2pnjB-5kqvE:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5kqv INSULIN
RECEPTOR,INSULIN
RECEPTOR
(Homo
sapiens) 		6 / 12 LEU E 385
PHE E 382
LEU E 419
ILE E 336
SER E 446
LEU E 426
 None
 1.47A 2po5A-5kqvE:
undetectable		 2po5A-5kqvE:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5kqv INSULIN
RECEPTOR,INSULIN
RECEPTOR
(Homo
sapiens) 		5 / 11 LEU E 385
PHE E 382
LEU E 419
SER E 446
LEU E 426
 None
 1.23A 2po5B-5kqvE:
undetectable		 2po5B-5kqvE:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 5kqv INSULIN
RECEPTOR,INSULIN
RECEPTOR
(Homo
sapiens) 		5 / 12 LEU E 385
PHE E 382
LEU E 419
ILE E 336
SER E 446
 None
 1.13A 3aqiB-5kqvE:
undetectable		 3aqiB-5kqvE:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 5kqv INSULIN
RECEPTOR,INSULIN
RECEPTOR
(Homo
sapiens) 		4 / 7 ASP E 142
ILE E  95
SER E 116
TYR E  91
 None
 0.97A 3pglA-5kqvE:
undetectable		 3pglA-5kqvE:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 5kqv INSULIN
RECEPTOR,INSULIN
RECEPTOR
(Homo
sapiens) 		5 / 10 ILE E 336
GLY E 338
GLY E 317
SER E 326
THR E 320
 None
 0.98A 4fakA-5kqvE:
undetectable		 4fakA-5kqvE:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 5kqv INSULIN
RECEPTOR,INSULIN
RECEPTOR
(Homo
sapiens) 		4 / 7 ILE E  13
LEU E  17
PHE E  46
GLY E  68
 None
 1.00A 4hbfA-5kqvE:
undetectable		 4hbfA-5kqvE:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 5kqv INSULIN
RECEPTOR,INSULIN
RECEPTOR
(Homo
sapiens) 		4 / 7 ILE E  13
LEU E  17
PHE E  46
GLY E  68
 None
 1.05A 4hc3A-5kqvE:
undetectable		 4hc3A-5kqvE:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 5kqv INSULIN
RECEPTOR,INSULIN
RECEPTOR
(Homo
sapiens) 		5 / 10 LEU E 354
LEU E 330
LEU E 340
ILE E 342
PHE E 381
 None
 1.05A 4odoA-5kqvE:
undetectable		 4odoA-5kqvE:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 5kqv INSULIN
RECEPTOR,INSULIN
RECEPTOR
(Homo
sapiens) 		5 / 10 LEU E 354
LEU E 330
LEU E 340
ILE E 342
PHE E 381
 None
 1.10A 4odoB-5kqvE:
undetectable		 4odoB-5kqvE:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 5kqv INSULIN
RECEPTOR,INSULIN
RECEPTOR
(Homo
sapiens) 		3 / 3 TYR E 401
ARG E 371
LYS E 369
 None
 1.25A 4wq5B-5kqvE:
undetectable		 4wq5B-5kqvE:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 5kqv INSULIN
RECEPTOR,INSULIN
RECEPTOR
(Homo
sapiens) 		3 / 3 THR E 461
ALA E 458
ASN E 462
 None
 0.50A 5ersA-5kqvE:
undetectable		 5ersA-5kqvE:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 5kqv INSULIN
RECEPTOR,INSULIN
RECEPTOR
(Homo
sapiens) 		5 / 12 VAL E 117
ILE E 119
LEU E  72
LEU E  61
LEU E  63
 None
 1.29A 5tiwA-5kqvE:
undetectable		 5tiwA-5kqvE:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_D8ZA831_0
(GEPHYRIN)		 5kqv INSULIN
RECEPTOR,INSULIN
RECEPTOR
(Homo
sapiens) 		5 / 11 ILE E 478
LEU E 473
ARG E 488
PRO E 549
ILE E 534
 None
 1.27A 6fgdA-5kqvE:
undetectable		 6fgdA-5kqvE:
8.70