SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kqw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 5kqw 4-AMINOBUTYRATE
TRANSAMINASE
(Pseudomonas) 		5 / 12 THR A  92
ALA A  94
GLU A  97
LEU A  98
LEU A 297
 None
 0.98A 1errB-5kqwA:
undetectable		 1errB-5kqwA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 5kqw 4-AMINOBUTYRATE
TRANSAMINASE
(Pseudomonas) 		5 / 9 TYR A 294
GLY A  64
ILE A 342
ALA A 338
GLU A  69
 None
 1.26A 1mrgA-5kqwA:
undetectable		 1mrgA-5kqwA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 5kqw 4-AMINOBUTYRATE
TRANSAMINASE
(Pseudomonas) 		4 / 8 ILE A 147
SER A 148
LEU A 211
GLU A 215
 None
 0.96A 2cdqA-5kqwA:
undetectable		 2cdqA-5kqwA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 5kqw 4-AMINOBUTYRATE
TRANSAMINASE
(Pseudomonas) 		4 / 8 VAL A 306
ASN A 135
ALA A 222
GLN A 127
 None
 1.09A 2ij7C-5kqwA:
undetectable		 2ij7C-5kqwA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_1
(ESTROGEN RECEPTOR)		 5kqw 4-AMINOBUTYRATE
TRANSAMINASE
(Pseudomonas) 		5 / 12 THR A  92
ALA A  94
GLU A  97
LEU A  98
LEU A 337
 None
 1.04A 2jfaA-5kqwA:
undetectable		 2jfaA-5kqwA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 5kqw 4-AMINOBUTYRATE
TRANSAMINASE
(Pseudomonas) 		5 / 11 HIS A 187
LEU A 385
GLY A 374
GLU A 375
ALA A 384
 None
 1.11A 2yy8A-5kqwA:
undetectable
2yy8B-5kqwA:
undetectable		 2yy8A-5kqwA:
17.71
2yy8B-5kqwA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5kqw 4-AMINOBUTYRATE
TRANSAMINASE
(Pseudomonas) 		5 / 12 ALA A  56
LEU A 433
GLY A  64
ALA A 335
ASN A  62
 None
 1.24A 3tm4A-5kqwA:
undetectable		 3tm4A-5kqwA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5kqw 4-AMINOBUTYRATE
TRANSAMINASE
(Pseudomonas) 		5 / 12 ALA A  56
LEU A 433
GLY A  64
ALA A 335
ASN A  62
 None
 1.23A 3tm4B-5kqwA:
undetectable		 3tm4B-5kqwA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		 5kqw 4-AMINOBUTYRATE
TRANSAMINASE
(Pseudomonas) 		4 / 7 ASP A  11
ARG A  33
HIS A  46
HIS A  25
 None
 1.39A 3zodA-5kqwA:
undetectable		 3zodA-5kqwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 5kqw 4-AMINOBUTYRATE
TRANSAMINASE
(Pseudomonas) 		4 / 7 ILE A 235
PRO A 236
GLY A 380
ALA A 384
 None
 0.81A 4g0uB-5kqwA:
undetectable		 4g0uB-5kqwA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A206_1
(UNCHARACTERIZED
PROTEIN)		 5kqw 4-AMINOBUTYRATE
TRANSAMINASE
(Pseudomonas) 		5 / 10 TYR A 241
PRO A 237
ARG A 149
GLY A 225
LEU A 268
 None
 1.47A 4kouA-5kqwA:
undetectable		 4kouA-5kqwA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOV_A_KOVA204_1
(UNCHARACTERIZED
PROTEIN)		 5kqw 4-AMINOBUTYRATE
TRANSAMINASE
(Pseudomonas) 		5 / 12 TYR A 241
PRO A 237
ARG A 149
GLY A 225
LEU A 268
 None
 1.50A 4kovA-5kqwA:
undetectable		 4kovA-5kqwA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 5kqw 4-AMINOBUTYRATE
TRANSAMINASE
(Pseudomonas) 		4 / 7 GLU A 226
ARG A 377
GLY A 233
GLY A 230
 None
 0.78A 4rdxA-5kqwA:
undetectable		 4rdxA-5kqwA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5kqw 4-AMINOBUTYRATE
TRANSAMINASE
(Pseudomonas) 		4 / 6 VAL A 444
LEU A 427
LEU A 385
HIS A 370
 None
 1.02A 6e43C-5kqwA:
undetectable		 6e43C-5kqwA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5kqw 4-AMINOBUTYRATE
TRANSAMINASE
(Pseudomonas) 		4 / 6 VAL A 444
LEU A 427
LEU A 385
HIS A 370
 None
 1.01A 6e43D-5kqwA:
undetectable		 6e43D-5kqwA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5kqw 4-AMINOBUTYRATE
TRANSAMINASE
(Pseudomonas) 		5 / 9 LEU A 208
ILE A 254
PRO A 217
VAL A 220
ILE A 212
 None
 1.22A 6ef6A-5kqwA:
undetectable		 6ef6A-5kqwA:
24.43