SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kr6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5kr6 4-AMINOBUTYRATE
TRANSAMINASE
(Pseudomonas) 		5 / 12 ILE A 331
CYH A 332
ALA A 334
ALA A 335
ALA A  73
 None
 1.08A 1fbyA-5kr6A:
undetectable		 1fbyA-5kr6A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5kr6 4-AMINOBUTYRATE
TRANSAMINASE
(Pseudomonas) 		5 / 12 ILE A 331
CYH A 332
ALA A 334
ALA A 335
ALA A  73
 None
 1.08A 1fbyB-5kr6A:
undetectable		 1fbyB-5kr6A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 5kr6 4-AMINOBUTYRATE
TRANSAMINASE
(Pseudomonas) 		4 / 8 PHE A 272
GLY A 266
ARG A 267
LEU A 433
 None
 0.76A 1gsfA-5kr6A:
undetectable		 1gsfA-5kr6A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 5kr6 4-AMINOBUTYRATE
TRANSAMINASE
(Pseudomonas) 		4 / 8 PHE A 272
GLY A 266
ARG A 267
LEU A 433
 None
 0.76A 1gsfB-5kr6A:
undetectable		 1gsfB-5kr6A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 5kr6 4-AMINOBUTYRATE
TRANSAMINASE
(Pseudomonas) 		4 / 8 PHE A 272
GLY A 266
ARG A 267
LEU A 433
 None
 0.76A 1gsfD-5kr6A:
undetectable		 1gsfD-5kr6A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5kr6 4-AMINOBUTYRATE
TRANSAMINASE
(Pseudomonas) 		5 / 9 MET A 363
PHE A 359
GLY A 378
LEU A 381
GLY A 356
 None
 1.41A 1jb0A-5kr6A:
0.1		 1jb0A-5kr6A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 5kr6 4-AMINOBUTYRATE
TRANSAMINASE
(Pseudomonas) 		5 / 9 TYR A 294
GLY A  64
ILE A 342
ALA A 338
GLU A  69
 None
 1.26A 1mrgA-5kr6A:
undetectable		 1mrgA-5kr6A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 5kr6 4-AMINOBUTYRATE
TRANSAMINASE
(Pseudomonas) 		5 / 12 HIS A 275
LEU A 256
THR A 285
ILE A 284
GLN A 127
 None
 1.45A 1xlxA-5kr6A:
undetectable		 1xlxA-5kr6A:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 5kr6 4-AMINOBUTYRATE
TRANSAMINASE
(Pseudomonas) 		5 / 12 GLY A 380
GLY A 378
LEU A 381
PRO A 431
ILE A 435
 None
 0.97A 1zq9B-5kr6A:
undetectable		 1zq9B-5kr6A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 5kr6 4-AMINOBUTYRATE
TRANSAMINASE
(Pseudomonas) 		4 / 8 VAL A 306
ASN A 135
ALA A 222
GLN A 127
 None
 1.10A 2ij7C-5kr6A:
undetectable		 2ij7C-5kr6A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5kr6 4-AMINOBUTYRATE
TRANSAMINASE
(Pseudomonas) 		4 / 8 PRO A 405
SER A 408
PRO A 422
MET A 421
 None
 1.13A 3hcrA-5kr6A:
undetectable		 3hcrA-5kr6A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_A_PQNA847_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5kr6 4-AMINOBUTYRATE
TRANSAMINASE
(Pseudomonas) 		5 / 9 MET A 363
PHE A 359
GLY A 378
LEU A 381
GLY A 356
 None
 1.42A 3pcqA-5kr6A:
undetectable		 3pcqA-5kr6A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5kr6 4-AMINOBUTYRATE
TRANSAMINASE
(Pseudomonas) 		5 / 12 ALA A  56
LEU A 433
GLY A  64
ALA A 335
ASN A  62
 None
 1.26A 3tm4A-5kr6A:
undetectable		 3tm4A-5kr6A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5kr6 4-AMINOBUTYRATE
TRANSAMINASE
(Pseudomonas) 		5 / 12 ALA A  56
LEU A 433
GLY A  64
ALA A 335
ASN A  62
 None
 1.25A 3tm4B-5kr6A:
2.0		 3tm4B-5kr6A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5kr6 4-AMINOBUTYRATE
TRANSAMINASE
(Pseudomonas) 		3 / 3 ASP A 392
LYS A 391
ASP A 390
 None
 0.62A 4a7tA-5kr6A:
undetectable		 4a7tA-5kr6A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 5kr6 4-AMINOBUTYRATE
TRANSAMINASE
(Pseudomonas) 		3 / 3 GLU A 386
ARG A 190
HIS A 187
 None
 0.75A 4kf9A-5kr6A:
undetectable		 4kf9A-5kr6A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 5kr6 4-AMINOBUTYRATE
TRANSAMINASE
(Pseudomonas) 		4 / 6 GLU A 439
ASP A  53
ASN A  62
ARG A 267
 None
 1.33A 4ntxA-5kr6A:
undetectable
4ntxC-5kr6A:
undetectable		 4ntxA-5kr6A:
21.16
4ntxC-5kr6A:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 5kr6 4-AMINOBUTYRATE
TRANSAMINASE
(Pseudomonas) 		4 / 7 GLU A 226
ARG A 377
GLY A 233
GLY A 230
 PLP  A 501 (-3.8A)
None
None
None
 0.80A 4rdxA-5kr6A:
undetectable		 4rdxA-5kr6A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_C_PACC601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 5kr6 4-AMINOBUTYRATE
TRANSAMINASE
(Pseudomonas) 		5 / 12 PRO A 108
PHE A 272
PHE A 265
ILE A 284
VAL A 114
 None
 1.11A 4yfbC-5kr6A:
0.0		 4yfbC-5kr6A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_F_PACF601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 5kr6 4-AMINOBUTYRATE
TRANSAMINASE
(Pseudomonas) 		5 / 12 PRO A 108
PHE A 272
PHE A 265
ILE A 284
VAL A 114
 None
 1.10A 4yfbF-5kr6A:
0.0		 4yfbF-5kr6A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_I_PACI601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 5kr6 4-AMINOBUTYRATE
TRANSAMINASE
(Pseudomonas) 		5 / 12 PRO A 108
PHE A 272
PHE A 265
ILE A 284
VAL A 114
 None
 1.12A 4yfbI-5kr6A:
undetectable		 4yfbI-5kr6A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_L_PACL601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 5kr6 4-AMINOBUTYRATE
TRANSAMINASE
(Pseudomonas) 		5 / 12 PRO A 108
PHE A 272
PHE A 265
ILE A 284
VAL A 114
 None
 1.10A 4yfbL-5kr6A:
undetectable		 4yfbL-5kr6A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8R_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5kr6 4-AMINOBUTYRATE
TRANSAMINASE
(Pseudomonas) 		5 / 9 MET A 363
PHE A 359
GLY A 378
LEU A 381
GLY A 356
 None
 1.40A 5l8rA-5kr6A:
undetectable		 5l8rA-5kr6A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5kr6 4-AMINOBUTYRATE
TRANSAMINASE
(Pseudomonas) 		4 / 6 VAL A 444
LEU A 427
LEU A 385
HIS A 370
 None
 1.02A 6e43C-5kr6A:
undetectable		 6e43C-5kr6A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5kr6 4-AMINOBUTYRATE
TRANSAMINASE
(Pseudomonas) 		4 / 6 VAL A 444
LEU A 427
LEU A 385
HIS A 370
 None
 1.02A 6e43D-5kr6A:
undetectable		 6e43D-5kr6A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5kr6 4-AMINOBUTYRATE
TRANSAMINASE
(Pseudomonas) 		5 / 9 LEU A 208
ILE A 254
PRO A 217
VAL A 220
ILE A 212
 None
 1.21A 6ef6A-5kr6A:
undetectable		 6ef6A-5kr6A:
25.60