SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kre'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_B_803B311_1
(ANTIGEN CD11A (P180))		 5kre LYSOPHOSPHOLIPASE-LI
KE PROTEIN 1
(Homo
sapiens) 		4 / 7 VAL A 157
LEU A 171
VAL A 144
LEU A 151
 None
 0.80A 1cqpA-5kreA:
4.0
1cqpB-5kreA:
4.0		 1cqpA-5kreA:
19.67
1cqpB-5kreA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 5kre LYSOPHOSPHOLIPASE-LI
KE PROTEIN 1
(Homo
sapiens) 		5 / 9 LEU A  49
ILE A  41
LEU A 119
GLY A 122
LEU A 221
 None
 1.12A 1e7aB-5kreA:
undetectable		 1e7aB-5kreA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)		 5kre LYSOPHOSPHOLIPASE-LI
KE PROTEIN 1
(Homo
sapiens) 		4 / 7 TYR A  58
PHE A  26
PHE A 145
ILE A  41
 None
 1.00A 2zseA-5kreA:
undetectable		 2zseA-5kreA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 5kre LYSOPHOSPHOLIPASE-LI
KE PROTEIN 1
(Homo
sapiens) 		3 / 3 PHE A 172
CYH A 174
PHE A 206
 None
 1.14A 3cr5X-5kreA:
undetectable		 3cr5X-5kreA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 5kre LYSOPHOSPHOLIPASE-LI
KE PROTEIN 1
(Homo
sapiens) 		5 / 12 TYR A 135
GLY A 127
GLY A 121
PHE A 123
SER A 149
 None
None
None
None
NO3  A 302 (-4.1A)
 1.38A 3dlcA-5kreA:
undetectable		 3dlcA-5kreA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5kre LYSOPHOSPHOLIPASE-LI
KE PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 221
ILE A  56
LEU A  49
PHE A  51
THR A 227
 None
 1.10A 3fl9B-5kreA:
undetectable		 3fl9B-5kreA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5kre LYSOPHOSPHOLIPASE-LI
KE PROTEIN 1
(Homo
sapiens) 		5 / 11 LEU A 221
ILE A  56
LEU A  49
PHE A  51
THR A 227
 None
 1.19A 3fl9C-5kreA:
undetectable		 3fl9C-5kreA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5kre LYSOPHOSPHOLIPASE-LI
KE PROTEIN 1
(Homo
sapiens) 		6 / 10 LEU A 119
LEU A 221
ILE A  56
LEU A  49
PHE A  51
THR A 227
 None
 1.22A 3fl9E-5kreA:
undetectable		 3fl9E-5kreA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 5kre LYSOPHOSPHOLIPASE-LI
KE PROTEIN 1
(Homo
sapiens) 		5 / 9 ALA A  61
GLY A  34
LEU A 104
LEU A  27
ILE A  25
 None
 1.16A 3wdmC-5kreA:
undetectable		 3wdmC-5kreA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5kre LYSOPHOSPHOLIPASE-LI
KE PROTEIN 1
(Homo
sapiens) 		6 / 12 GLY A 121
GLY A 122
GLY A 127
LEU A 133
VAL A 144
VAL A 141
 None
 1.48A 4htfA-5kreA:
undetectable		 4htfA-5kreA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5kre LYSOPHOSPHOLIPASE-LI
KE PROTEIN 1
(Homo
sapiens) 		6 / 12 GLY A 121
GLY A 122
GLY A 127
LEU A 133
VAL A 144
VAL A 141
 None
 1.42A 4htfB-5kreA:
2.7		 4htfB-5kreA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5kre LYSOPHOSPHOLIPASE-LI
KE PROTEIN 1
(Homo
sapiens) 		3 / 3 LEU A 161
ARG A 136
MET A  97
 None
 0.78A 4m11C-5kreA:
undetectable		 4m11C-5kreA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 5kre LYSOPHOSPHOLIPASE-LI
KE PROTEIN 1
(Homo
sapiens) 		5 / 11 LEU A 194
PHE A 150
LEU A 171
ALA A 146
PHE A  78
 None
NO3  A 302 (-4.4A)
None
None
None
 1.08A 4wnuA-5kreA:
undetectable		 4wnuA-5kreA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 5kre LYSOPHOSPHOLIPASE-LI
KE PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A  49
PHE A 145
LEU A 147
GLY A 121
LEU A  37
 None
 1.33A 4zbrA-5kreA:
undetectable		 4zbrA-5kreA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 5kre LYSOPHOSPHOLIPASE-LI
KE PROTEIN 1
(Homo
sapiens) 		5 / 12 GLN A 139
ALA A 130
VAL A 144
LEU A 161
SER A 164
 None
 1.05A 5hv1A-5kreA:
undetectable		 5hv1A-5kreA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5kre LYSOPHOSPHOLIPASE-LI
KE PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 101
PHE A  26
GLY A 126
LEU A 171
LEU A 218
 None
 1.23A 5y2tA-5kreA:
undetectable		 5y2tA-5kreA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5kre LYSOPHOSPHOLIPASE-LI
KE PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 104
PHE A  26
LEU A 229
ILE A 118
LEU A 218
 None
 1.25A 5y2tA-5kreA:
undetectable		 5y2tA-5kreA:
undetectable