SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ks8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA
(Methylobacillus
flagellatus) 		3 / 4 VAL A 399
TRP A 391
TRP A 395
 None
 1.20A 1gmkC-5ks8A:
undetectable
1gmkD-5ks8A:
undetectable		 1gmkC-5ks8A:
3.53
1gmkD-5ks8A:
3.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		4 / 7 HIS C 205
LEU C  18
SER C  17
ASP C  13
 MN  C2002 (-3.6A)
None
None
MN  C2002 (-2.4A)
 1.20A 1ismB-5ks8C:
undetectable		 1ismB-5ks8C:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		5 / 12 GLY C 228
THR C 242
LEU C  78
VAL C  10
LEU C  11
 None
 1.34A 1jipA-5ks8C:
undetectable		 1jipA-5ks8C:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		5 / 12 GLY C 228
ALA C 211
GLY C  14
SER C 238
HIS C 205
 None
None
None
None
MN  C2002 (-3.6A)
 1.08A 1kiaA-5ks8C:
undetectable		 1kiaA-5ks8C:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA
(Methylobacillus
flagellatus) 		5 / 12 ILE A   5
LEU A   6
HIS A  41
LEU A  84
ILE A  65
 None
 1.18A 1kyvC-5ks8A:
3.5
1kyvD-5ks8A:
2.3		 1kyvC-5ks8A:
17.04
1kyvD-5ks8A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA
(Methylobacillus
flagellatus) 		3 / 3 ALA A  62
HIS A  63
VAL A  66
 None
 0.34A 1lqtB-5ks8A:
3.3		 1lqtB-5ks8A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA
(Methylobacillus
flagellatus) 		3 / 3 ALA A  62
HIS A  63
VAL A  66
 None
 0.35A 1lquB-5ks8A:
2.7		 1lquB-5ks8A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA
(Methylobacillus
flagellatus) 		4 / 8 ILE A 354
GLU A  12
GLY A  11
ARG A  10
 None
 0.97A 1meiA-5ks8A:
undetectable		 1meiA-5ks8A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		5 / 12 GLY C 228
ALA C 211
GLY C  14
SER C 238
HIS C 205
 None
None
None
None
MN  C2002 (-3.6A)
 1.08A 1nbiA-5ks8C:
undetectable		 1nbiA-5ks8C:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		5 / 12 GLY C 228
ALA C 211
GLY C  14
SER C 238
HIS C 205
 None
None
None
None
MN  C2002 (-3.6A)
 1.07A 1nbiB-5ks8C:
undetectable		 1nbiB-5ks8C:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA
(Methylobacillus
flagellatus) 		5 / 12 PHE A  83
GLY A  80
ILE A   7
VAL A 294
GLU A 335
 None
 1.22A 1sg9A-5ks8A:
3.8		 1sg9A-5ks8A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		4 / 6 ARG C  91
PHE C 101
ALA C 100
LEU C 410
 None
 1.00A 1ukbA-5ks8C:
undetectable		 1ukbA-5ks8C:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XR2_B_C2FB1201_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		4 / 8 LYS C 174
THR C  50
SER C 238
GLU C 281
 MN  C2002 ( 2.7A)
None
None
None
 1.23A 1xr2B-5ks8C:
2.3		 1xr2B-5ks8C:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_1
(GAG-POL POLYPROTEIN)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA
(Methylobacillus
flagellatus) 		5 / 12 ALA A  76
ASP A  75
ILE A 312
ILE A  26
ILE A 102
 None
 0.92A 2b60A-5ks8A:
undetectable		 2b60A-5ks8A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_1
(HIV-1 PROTEASE)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA
(Methylobacillus
flagellatus) 		5 / 12 ALA A  76
ASP A  75
ILE A 312
ILE A  26
ILE A 102
 None
 0.82A 2hs1A-5ks8A:
undetectable		 2hs1A-5ks8A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		4 / 6 PRO C 543
LEU C 611
ARG C 542
GLY C 539
 None
 1.04A 2hs2B-5ks8C:
undetectable		 2hs2B-5ks8C:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		5 / 12 SER C 232
ASP C 259
LEU C 262
GLY C 261
VAL C  38
 None
 1.09A 2kceB-5ks8C:
undetectable		 2kceB-5ks8C:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_A_GEOA302_1
(DEOXYCYTIDINE KINASE)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA
(Methylobacillus
flagellatus) 		5 / 12 GLU A 300
VAL A 308
LEU A 292
TYR A  81
ARG A 366
 None
 1.42A 2no0A-5ks8A:
undetectable		 2no0A-5ks8A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_B_GEOB302_1
(DEOXYCYTIDINE KINASE)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA
(Methylobacillus
flagellatus) 		5 / 12 GLU A 300
VAL A 308
LEU A 292
TYR A  81
ARG A 366
 None
 1.42A 2no0B-5ks8A:
undetectable		 2no0B-5ks8A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		5 / 10 ASP C   8
LEU C  43
VAL C  10
PHE C 270
THR C 242
 None
 1.11A 2w9hA-5ks8C:
undetectable		 2w9hA-5ks8C:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA
(Methylobacillus
flagellatus) 		4 / 8 LYS A 236
ASN A 289
ARG A 291
GLU A 295
 None
 0.90A 2ys6A-5ks8A:
27.8		 2ys6A-5ks8A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA
(Methylobacillus
flagellatus) 		4 / 5 GLN A 211
ALA A 270
GLN A 311
ILE A 307
 None
 1.32A 2z0aA-5ks8A:
undetectable		 2z0aA-5ks8A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA
(Methylobacillus
flagellatus) 		5 / 12 CYH A 385
ALA A 340
THR A 417
THR A 416
ILE A 338
 None
 1.22A 3a35A-5ks8A:
undetectable		 3a35A-5ks8A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		5 / 12 LEU C 188
THR C 185
ASP C 175
THR C 142
ILE C 171
 None
 1.21A 3a35A-5ks8C:
undetectable		 3a35A-5ks8C:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		5 / 12 LEU C 188
THR C 185
ASP C 175
THR C 142
ILE C 171
 None
 1.19A 3a35B-5ks8C:
undetectable		 3a35B-5ks8C:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3B_A_RBFA191_1
(LUMAZINE PROTEIN)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA
(Methylobacillus
flagellatus) 		5 / 12 CYH A 385
ALA A 340
THR A 417
THR A 416
ILE A 338
 None
 1.21A 3a3bA-5ks8A:
undetectable		 3a3bA-5ks8A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3B_A_RBFA191_1
(LUMAZINE PROTEIN)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		5 / 12 LEU C 188
THR C 185
ASP C 175
THR C 142
ILE C 171
 None
 1.22A 3a3bA-5ks8C:
undetectable		 3a3bA-5ks8C:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_1
(PHOSPHOLIPASE A2)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA
(Methylobacillus
flagellatus) 		5 / 10 VAL A 398
VAL A 399
GLU A 400
GLY A 402
THR A 389
 None
 1.19A 3bjwD-5ks8A:
undetectable		 3bjwD-5ks8A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_1
(PROTEASE)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		5 / 11 LEU C 321
ALA C 348
PRO C 297
VAL C 296
ILE C 324
 None
 1.00A 3el1A-5ks8C:
undetectable		 3el1A-5ks8C:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		3 / 3 MET C  80
MET C  23
PHE C  51
 None
 1.38A 3gn8A-5ks8C:
undetectable		 3gn8A-5ks8C:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		4 / 4 LEU C 304
ALA C 348
VAL C 327
PRO C 325
 None
 1.22A 3gv1B-5ks8C:
undetectable		 3gv1B-5ks8C:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		5 / 12 LEU C 125
SER C 105
THR C 142
GLY C  48
LEU C  81
 None
None
None
PYR  C2001 (-3.5A)
PYR  C2001 (-4.7A)
 1.20A 3j6pB-5ks8C:
2.6		 3j6pB-5ks8C:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA
(Methylobacillus
flagellatus) 		5 / 11 ILE A 365
GLY A 361
LEU A 388
LEU A 406
ALA A 405
 None
 1.28A 3kw2B-5ks8A:
undetectable		 3kw2B-5ks8A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA
(Methylobacillus
flagellatus) 		5 / 12 ILE A 127
ALA A 258
LEU A 257
HIS A 207
GLY A 271
 None
 1.01A 3ozwB-5ks8A:
3.7		 3ozwB-5ks8A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA
(Methylobacillus
flagellatus) 		5 / 9 ILE A 354
ILE A 377
VAL A 411
THR A 416
ILE A 338
 None
 1.21A 3p4wB-5ks8A:
undetectable		 3p4wB-5ks8A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA
(Methylobacillus
flagellatus) 		5 / 10 ILE A 354
ILE A 377
VAL A 411
THR A 416
ILE A 338
 None
 1.23A 3p4wD-5ks8A:
undetectable		 3p4wD-5ks8A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA
(Methylobacillus
flagellatus) 		5 / 10 ILE A 354
ILE A 377
VAL A 411
THR A 416
ILE A 338
 None
 1.21A 3p4wE-5ks8A:
undetectable		 3p4wE-5ks8A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA
(Methylobacillus
flagellatus) 		3 / 3 HIS A 296
ARG A  16
GLU A  12
 None
 1.16A 3qf1A-5ks8A:
undetectable		 3qf1A-5ks8A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		4 / 5 GLY C 374
ASP C 121
ARG C 398
MET C 429
 None
 1.29A 3qx3A-5ks8C:
undetectable		 3qx3A-5ks8C:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		4 / 5 GLY C 374
ASP C 121
ARG C 398
MET C 429
 None
 1.28A 3qx3B-5ks8C:
undetectable		 3qx3B-5ks8C:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		5 / 12 LEU C  81
ARG C 114
HIS C 203
HIS C 205
SER C  17
 PYR  C2001 (-4.7A)
None
MN  C2002 (-3.5A)
MN  C2002 (-3.6A)
None
 1.35A 4aqlA-5ks8C:
5.4		 4aqlA-5ks8C:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_1
(ADENOSINE KINASE)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		5 / 12 ASP C   8
GLY C 228
ALA C 241
VAL C  10
LEU C  18
 None
 0.87A 4dc3A-5ks8C:
undetectable		 4dc3A-5ks8C:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_C_ACTC506_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA
(Methylobacillus
flagellatus) 		4 / 5 ARG A  16
ILE A  17
HIS A  78
GLY A  80
 None
 1.18A 4e7cC-5ks8A:
undetectable		 4e7cC-5ks8A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA
(Methylobacillus
flagellatus) 		4 / 6 ASP A 382
ASP A  36
ASN A   9
GLU A  12
 None
 1.32A 4gkhJ-5ks8A:
undetectable		 4gkhJ-5ks8A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA
(Methylobacillus
flagellatus) 		4 / 6 GLU A 295
ARG A 337
GLU A 209
GLU A 274
 None
 1.39A 4kr3A-5ks8A:
3.3		 4kr3A-5ks8A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA
(Methylobacillus
flagellatus) 		4 / 7 HIS A  78
ILE A  26
ILE A   5
ALA A  76
 None
 0.89A 4lv9B-5ks8A:
undetectable		 4lv9B-5ks8A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		5 / 12 LEU C  81
THR C 142
GLU C  44
ASP C 227
HIS C 201
 PYR  C2001 (-4.7A)
None
None
None
None
 1.24A 4lvcC-5ks8C:
undetectable		 4lvcC-5ks8C:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		3 / 3 PRO C 339
ASN C  86
HIS C  92
 None
 0.93A 4ma3H-5ks8C:
undetectable
4ma3L-5ks8C:
undetectable		 4ma3H-5ks8C:
16.29
4ma3L-5ks8C:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		5 / 9 VAL C 574
ALA C 573
GLY C 592
SER C 589
GLY C 571
 None
 1.38A 4mmeA-5ks8C:
undetectable		 4mmeA-5ks8C:
20.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA
(Methylobacillus
flagellatus) 		6 / 7 LYS A 236
ASN A 289
ARG A 291
GLN A 293
GLU A 295
ARG A 337
 None
 0.79A 4mv7A-5ks8A:
57.2		 4mv7A-5ks8A:
41.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA
(Methylobacillus
flagellatus) 		6 / 7 LYS A 236
ASN A 289
GLN A 293
VAL A 294
GLU A 295
ARG A 337
 None
 0.75A 4mv7A-5ks8A:
57.2		 4mv7A-5ks8A:
41.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		4 / 5 LEU C  73
SER C  33
LEU C  29
LEU C  43
 None
 1.24A 4n09B-5ks8C:
2.5		 4n09B-5ks8C:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		4 / 5 LEU C  73
SER C  33
LEU C  29
LEU C  43
 None
 1.27A 4n09D-5ks8C:
2.1		 4n09D-5ks8C:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		5 / 12 LEU C  81
THR C 142
GLU C  44
ASP C 227
HIS C 201
 PYR  C2001 (-4.7A)
None
None
None
None
 1.29A 4pfjA-5ks8C:
undetectable		 4pfjA-5ks8C:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		5 / 12 GLY C 236
GLY C 286
LEU C 239
ASP C  13
ALA C 211
 None
None
None
MN  C2002 (-2.4A)
None
 1.15A 4uckB-5ks8C:
undetectable		 4uckB-5ks8C:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_C_PACC601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA
(Methylobacillus
flagellatus) 		5 / 12 PHE A 435
ILE A 424
VAL A 398
TRP A 395
VAL A 399
 None
 1.12A 4yfbC-5ks8A:
undetectable		 4yfbC-5ks8A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_F_PACF601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA
(Methylobacillus
flagellatus) 		5 / 12 PHE A 435
ILE A 424
VAL A 398
TRP A 395
VAL A 399
 None
 1.13A 4yfbF-5ks8A:
undetectable		 4yfbF-5ks8A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_I_PACI601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA
(Methylobacillus
flagellatus) 		5 / 12 PHE A 435
ILE A 424
VAL A 398
TRP A 395
VAL A 399
 None
 1.16A 4yfbI-5ks8A:
undetectable		 4yfbI-5ks8A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_L_PACL601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA
(Methylobacillus
flagellatus) 		5 / 12 PHE A 435
ILE A 424
VAL A 398
TRP A 395
VAL A 399
 None
 1.15A 4yfbL-5ks8A:
undetectable		 4yfbL-5ks8A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		3 / 3 TYR C 254
THR C 256
THR C 252
 None
 0.73A 5aoxB-5ks8C:
1.1		 5aoxB-5ks8C:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		3 / 3 TYR C 254
THR C 256
THR C 252
 None
 0.81A 5aoxE-5ks8C:
undetectable		 5aoxE-5ks8C:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA
(Methylobacillus
flagellatus) 		5 / 12 ASP A  36
SER A  33
GLY A  58
LEU A  57
GLY A  80
 None
 1.21A 5i75A-5ks8A:
undetectable		 5i75A-5ks8A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		4 / 6 ASP C 175
ASP C 187
ARG C 217
ASN C 221
 None
 0.89A 5l6eA-5ks8C:
undetectable		 5l6eA-5ks8C:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		5 / 12 LEU C 125
SER C 105
THR C 142
GLY C  48
LEU C  81
 None
None
None
PYR  C2001 (-3.5A)
PYR  C2001 (-4.7A)
 1.33A 5m50E-5ks8C:
undetectable		 5m50E-5ks8C:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		5 / 12 LEU C  81
THR C 142
GLU C  44
ASP C 227
HIS C 201
 PYR  C2001 (-4.7A)
None
None
None
None
 1.28A 5m5kA-5ks8C:
undetectable		 5m5kA-5ks8C:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		5 / 12 LEU C  81
THR C 142
GLU C  44
ASP C 227
HIS C 201
 PYR  C2001 (-4.7A)
None
None
None
None
 1.19A 5m66B-5ks8C:
undetectable		 5m66B-5ks8C:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA
(Methylobacillus
flagellatus) 		5 / 10 ILE A 354
ILE A 377
MET A 371
VAL A 411
THR A 416
 None
 1.12A 5mzrA-5ks8A:
undetectable		 5mzrA-5ks8A:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA
(Methylobacillus
flagellatus) 		5 / 9 ILE A 354
ILE A 377
MET A 371
VAL A 411
THR A 416
 None
 1.14A 5mzrD-5ks8A:
undetectable		 5mzrD-5ks8A:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		3 / 3 LYS C 174
HIS C 205
HIS C 203
 MN  C2002 ( 2.7A)
MN  C2002 (-3.6A)
MN  C2002 (-3.5A)
 1.32A 5oexA-5ks8C:
undetectable		 5oexA-5ks8C:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		3 / 3 LYS C 174
HIS C 205
HIS C 203
 MN  C2002 ( 2.7A)
MN  C2002 (-3.6A)
MN  C2002 (-3.5A)
 1.34A 5oexB-5ks8C:
undetectable		 5oexB-5ks8C:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		3 / 3 LYS C 174
HIS C 205
HIS C 203
 MN  C2002 ( 2.7A)
MN  C2002 (-3.6A)
MN  C2002 (-3.5A)
 1.32A 5oexC-5ks8C:
undetectable		 5oexC-5ks8C:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		3 / 3 LYS C 174
HIS C 205
HIS C 203
 MN  C2002 ( 2.7A)
MN  C2002 (-3.6A)
MN  C2002 (-3.5A)
 1.28A 5oexD-5ks8C:
undetectable		 5oexD-5ks8C:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA
(Methylobacillus
flagellatus) 		3 / 3 GLU A  12
HIS A  41
VAL A  15
 None
 0.92A 5trqB-5ks8A:
undetectable		 5trqB-5ks8A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_A_ADNA502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		5 / 12 LEU C  81
THR C 142
GLU C  44
ASP C 227
HIS C 201
 PYR  C2001 (-4.7A)
None
None
None
None
 1.25A 5v96A-5ks8C:
undetectable		 5v96A-5ks8C:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_B_ADNB502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		5 / 12 LEU C  81
THR C 142
GLU C  44
ASP C 227
HIS C 201
 PYR  C2001 (-4.7A)
None
None
None
None
 1.25A 5v96B-5ks8C:
undetectable		 5v96B-5ks8C:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_C_ADNC502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		5 / 12 LEU C  81
THR C 142
GLU C  44
ASP C 227
HIS C 201
 PYR  C2001 (-4.7A)
None
None
None
None
 1.24A 5v96C-5ks8C:
undetectable		 5v96C-5ks8C:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_D_ADND502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		5 / 12 LEU C  81
THR C 142
GLU C  44
ASP C 227
HIS C 201
 PYR  C2001 (-4.7A)
None
None
None
None
 1.24A 5v96D-5ks8C:
undetectable		 5v96D-5ks8C:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		4 / 5 GLY C 374
ASP C 121
ARG C 398
MET C 429
 None
 1.25A 5zrfB-5ks8C:
undetectable		 5zrfB-5ks8C:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_F_EVPF1301_1
()		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		4 / 4 GLY C 374
ASP C 121
ARG C 398
MET C 429
 None
 1.27A 5zrfA-5ks8C:
undetectable		 5zrfA-5ks8C:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		5 / 12 LEU C  81
THR C 142
GLU C  44
ASP C 227
HIS C 201
 PYR  C2001 (-4.7A)
None
None
None
None
 1.26A 6aphA-5ks8C:
undetectable		 6aphA-5ks8C:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AY6_A_VORA501_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA
(Methylobacillus
flagellatus) 		5 / 9 TYR A  59
ALA A  14
ALA A  30
LEU A  68
LEU A  77
 None
 1.18A 6ay6A-5ks8A:
undetectable		 6ay6A-5ks8A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		5 / 12 VAL C   9
LEU C 180
HIS C 203
LEU C 202
GLY C 236
 None
None
MN  C2002 (-3.5A)
None
None
 1.19A 6b0lB-5ks8C:
undetectable		 6b0lB-5ks8C:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE SIGMA
FACTOR SIGA)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		4 / 4 LEU C 403
ASP C  95
GLN C  85
VAL C 389
 None
 1.34A 6bzoF-5ks8C:
undetectable		 6bzoF-5ks8C:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		5 / 12 TYR C  40
LEU C  43
ILE C 266
VAL C 273
THR C 242
 None
 1.21A 6djzB-5ks8C:
undetectable		 6djzB-5ks8C:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		5 / 12 TYR C  40
LEU C  43
SER C 232
ILE C 266
THR C 242
 None
 1.30A 6djzB-5ks8C:
undetectable		 6djzB-5ks8C:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_1
(-)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		5 / 12 LEU C  81
THR C 142
GLU C  44
ASP C 227
HIS C 201
 PYR  C2001 (-4.7A)
None
None
None
None
 1.27A 6gbnB-5ks8C:
undetectable		 6gbnB-5ks8C:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_1
(-)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		5 / 12 LEU C  81
THR C 142
GLU C  44
ASP C 227
HIS C 201
 PYR  C2001 (-4.7A)
None
None
None
None
 1.27A 6gbnC-5ks8C:
undetectable		 6gbnC-5ks8C:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA
(Methylobacillus
flagellatus) 		4 / 6 ASP A 368
GLU A 300
ASP A 306
GLU A  23
 None
 1.32A 6mn5A-5ks8A:
undetectable		 6mn5A-5ks8A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA
(Methylobacillus
flagellatus) 		4 / 6 ASP A 368
GLU A 300
ASP A 306
GLU A  23
 None
 1.43A 6mn5D-5ks8A:
undetectable		 6mn5D-5ks8A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA
(Methylobacillus
flagellatus) 		4 / 6 GLN C  79
PHE C 113
LEU C  88
PHE C  51
 None
 1.02A 6nmpC-5ks8C:
undetectable
6nmpJ-5ks8C:
undetectable		 6nmpC-5ks8C:
16.72
6nmpJ-5ks8C:
6.33