SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ksp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5ksp MITOCHONDRIAL RHO
GTPASE 1
(Homo
sapiens) 		3 / 3 SER A 479
HIS A 474
ASP A 490
 None
 0.70A 2oxtA-5kspA:
2.9		 2oxtA-5kspA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 5ksp MITOCHONDRIAL RHO
GTPASE 1
(Homo
sapiens) 		6 / 10 ALA A 458
LEU A 438
PHE A 570
VAL A 462
ILE A 569
ALA A 577
 None
 1.36A 4j14A-5kspA:
undetectable		 4j14A-5kspA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5ksp MITOCHONDRIAL RHO
GTPASE 1
(Homo
sapiens) 		4 / 7 ASN A 500
GLU A 537
GLU A 505
TYR A 506
 None
 1.23A 4mi4A-5kspA:
undetectable
4mi4C-5kspA:
undetectable		 4mi4A-5kspA:
22.17
4mi4C-5kspA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5ksp MITOCHONDRIAL RHO
GTPASE 1
(Homo
sapiens) 		4 / 8 ASN A 500
GLU A 537
GLU A 505
TYR A 506
 None
 1.20A 4mj8A-5kspA:
undetectable
4mj8C-5kspA:
undetectable		 4mj8A-5kspA:
21.46
4mj8C-5kspA:
21.46