SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ksw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 5ksw DIHYDROOROTATE
DEHYDROGENASE
DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
(Lactococcus
lactis;
Lactococcus
lactis) 		5 / 12 ALA B 233
THR A 198
LEU A 220
LEU B  51
LEU A 213
 FES  B 302 ( 4.3A)
FMN  A 401 ( 4.7A)
None
FAD  B 301 ( 4.2A)
None
 1.17A 1eiiA-5kswB:
undetectable		 1eiiA-5kswB:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 5ksw DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		4 / 6 ASN A 132
SER A 134
ASN A 197
THR A 198
 FMN  A 401 (-3.3A)
None
FMN  A 401 (-3.7A)
FMN  A 401 ( 4.7A)
 0.84A 1h7xA-5kswA:
36.1		 1h7xA-5kswA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 5ksw DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		4 / 6 ASN A 132
SER A 134
ASN A 197
THR A 198
 FMN  A 401 (-3.3A)
None
FMN  A 401 (-3.7A)
FMN  A 401 ( 4.7A)
 0.80A 1h7xB-5kswA:
7.4		 1h7xB-5kswA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 5ksw DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		4 / 6 ASN A 132
SER A 134
ASN A 197
THR A 198
 FMN  A 401 (-3.3A)
None
FMN  A 401 (-3.7A)
FMN  A 401 ( 4.7A)
 0.84A 1h7xC-5kswA:
36.1		 1h7xC-5kswA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 5ksw DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		4 / 6 ASN A 132
SER A 134
ASN A 197
THR A 198
 FMN  A 401 (-3.3A)
None
FMN  A 401 (-3.7A)
FMN  A 401 ( 4.7A)
 0.84A 1h7xD-5kswA:
36.2		 1h7xD-5kswA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5ksw DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
(Lactococcus
lactis) 		5 / 11 LEU B  98
ALA B  90
MET B   8
MET B  23
LEU B  29
 None
 1.33A 1iiuA-5kswB:
undetectable		 1iiuA-5kswB:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5ksw DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
(Lactococcus
lactis) 		5 / 11 LEU B 213
LEU B 114
VAL B 191
MET B 184
MET B 202
 None
 1.45A 1kt7A-5kswB:
undetectable		 1kt7A-5kswB:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 5ksw DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		4 / 5 PRO A  22
VAL A 269
VAL A 279
ILE A  20
 None
 1.07A 1z2bC-5kswA:
undetectable		 1z2bC-5kswA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ksw DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		4 / 7 LYS A 170
LEU A 131
LEU A 155
PHE A 145
 FMN  A 401 (-2.9A)
None
None
None
 0.97A 2eimC-5kswA:
undetectable
2eimJ-5kswA:
undetectable		 2eimC-5kswA:
19.93
2eimJ-5kswA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 5ksw DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
(Lactococcus
lactis) 		4 / 8 MET B 220
PRO B 124
SER B  56
GLY B 118
 None
None
FAD  B 301 (-2.9A)
None
 1.00A 2qd3A-5kswB:
2.7		 2qd3A-5kswB:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)		 5ksw DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
(Lactococcus
lactis) 		4 / 8 GLY B 119
ILE B 167
ASP B 171
SER B 173
 None
 0.65A 3pwwA-5kswB:
undetectable		 3pwwA-5kswB:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_B_GAIB408_0
(PROTEIN (ARGINASE))		 5ksw DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		4 / 5 ARG A   6
GLU A 289
MET A 291
ASP A 292
 None
 1.48A 4cevB-5kswA:
1.5
4cevC-5kswA:
1.5		 4cevB-5kswA:
25.16
4cevC-5kswA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 5ksw DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		4 / 6 ARG A   6
GLU A 289
MET A 291
ASP A 292
 None
 1.50A 4cevE-5kswA:
undetectable
4cevF-5kswA:
undetectable		 4cevE-5kswA:
25.16
4cevF-5kswA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF412_0
(PROTEIN (ARGINASE))		 5ksw DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		4 / 5 MET A 291
ASP A 292
ARG A   6
GLU A 289
 None
 1.49A 4cevD-5kswA:
undetectable
4cevF-5kswA:
undetectable		 4cevD-5kswA:
25.16
4cevF-5kswA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 5ksw DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
(Lactococcus
lactis) 		4 / 6 LEU B  40
LEU B  42
ILE B  83
MET B  23
 None
 0.92A 4do3B-5kswB:
1.4		 4do3B-5kswB:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIX_A_NIMA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5ksw DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		4 / 4 LEU A 232
ALA A 182
ILE A 181
LYS A 231
 None
 1.46A 4eixA-5kswA:
undetectable		 4eixA-5kswA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 5ksw DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		4 / 5 PHE A  29
ILE A  84
GLY A  80
THR A  51
 None
None
None
CL  A 402 (-3.8A)
 1.04A 4ejjC-5kswA:
undetectable		 4ejjC-5kswA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 5ksw DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		4 / 8 ALA A 266
SER A 265
LEU A  11
TYR A 168
 None
 1.18A 4ijiF-5kswA:
undetectable		 4ijiF-5kswA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA505_0
(RNA POLYMERASE
3D-POL)		 5ksw DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		3 / 3 CYH A  26
ASN A  72
LYS A  48
 FMN  A 401 (-3.6A)
FMN  A 401 (-3.1A)
FMN  A 401 (-3.3A)
 1.41A 4k50A-5kswA:
undetectable		 4k50A-5kswA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5ksw DIHYDROOROTATE
DEHYDROGENASE
DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
(Lactococcus
lactis;
Lactococcus
lactis) 		5 / 12 GLY A  28
ILE B 228
SER A  24
ASN A 273
PHE A 274
 None
None
FMN  A 401 (-3.2A)
None
None
 1.10A 4obwC-5kswA:
undetectable		 4obwC-5kswA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 5ksw DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
(Lactococcus
lactis) 		4 / 6 LEU B 132
GLU B 133
ASN B 162
MET B 139
 None
 0.87A 4ww7A-5kswB:
undetectable		 4ww7A-5kswB:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQC_A_51GA600_1
(BIFUNCTIONAL AAC/APH)		 5ksw DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
(Lactococcus
lactis) 		5 / 10 SER B  59
TYR B 126
GLU B 127
GLU B 133
GLU B 159
 None
 1.31A 5iqcA-5kswB:
0.0		 5iqcA-5kswB:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQC_D_51GD600_1
(BIFUNCTIONAL AAC/APH)		 5ksw DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
(Lactococcus
lactis) 		5 / 10 SER B  59
TYR B 126
GLU B 127
GLU B 133
GLU B 159
 None
 1.35A 5iqcD-5kswB:
undetectable		 5iqcD-5kswB:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQG_B_51GB600_1
(BIFUNCTIONAL AAC/APH)		 5ksw DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
(Lactococcus
lactis) 		5 / 10 SER B  59
TYR B 126
GLU B 127
GLU B 133
GLU B 159
 None
 1.30A 5iqgB-5kswB:
undetectable		 5iqgB-5kswB:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQG_D_51GD600_1
(BIFUNCTIONAL AAC/APH)		 5ksw DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
(Lactococcus
lactis) 		5 / 10 SER B  59
TYR B 126
GLU B 127
GLU B 133
GLU B 159
 None
 1.31A 5iqgD-5kswB:
0.0		 5iqgD-5kswB:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5ksw DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
(Lactococcus
lactis) 		4 / 6 LEU B 143
ILE B 218
THR B 196
MET B 220
 None
 1.39A 5ljeA-5kswB:
undetectable		 5ljeA-5kswB:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 5ksw DIHYDROOROTATE
DEHYDROGENASE
DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
(Lactococcus
lactis) 		6 / 12 GLU A  65
ALA B  47
LEU B  51
ALA A 275
VAL A 279
GLY A 222
 FAD  B 301 ( 4.6A)
None
FAD  B 301 ( 4.2A)
None
None
FMN  A 401 (-3.5A)
 1.44A 5te0A-5kswA:
undetectable		 5te0A-5kswA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ksw DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		4 / 6 LYS A 170
LEU A 131
LEU A 155
PHE A 145
 FMN  A 401 (-2.9A)
None
None
None
 1.00A 5w97C-5kswA:
undetectable
5w97J-5kswA:
undetectable		 5w97C-5kswA:
19.93
5w97J-5kswA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 5ksw DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		5 / 12 ALA A  23
GLY A 248
GLY A  43
LEU A  14
LEU A  16
 FMN  A 401 (-3.3A)
FMN  A 401 (-3.6A)
None
None
None
 1.15A 5wwsA-5kswA:
undetectable		 5wwsA-5kswA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ksw DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
(Lactococcus
lactis) 		4 / 5 TYR B  71
MET B  23
THR B  68
LEU B  25
 None
 1.43A 5x1bW-5kswB:
undetectable		 5x1bW-5kswB:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 5ksw DIHYDROOROTATE
DEHYDROGENASE
DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
(Lactococcus
lactis) 		4 / 6 TYR A  36
LEU B  40
GLU B  32
LEU B  29
 None
 0.91A 5xooA-5kswA:
undetectable		 5xooA-5kswA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_1
(SERUM ALBUMIN)		 5ksw DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		4 / 6 ASN A 104
TYR A 113
LEU A  76
SER A 134
 FMN  A 401 (-2.9A)
None
FMN  A 401 (-4.5A)
None
 1.48A 6a7pB-5kswA:
undetectable		 6a7pB-5kswA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGG_D_84GD600_0
(BIFUNCTIONAL AAC/APH)		 5ksw DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
(Lactococcus
lactis) 		5 / 11 SER B  59
TYR B 126
GLU B 127
GLU B 133
GLU B 159
 None
 1.39A 6cggD-5kswB:
0.0		 6cggD-5kswB:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 5ksw DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
(Lactococcus
lactis) 		5 / 12 LEU B  70
ILE B 152
LEU B 143
GLY B 117
ALA B 168
 None
 1.30A 6qxsD-5kswB:
undetectable		 6qxsD-5kswB:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 5ksw DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
(Lactococcus
lactis) 		5 / 12 LEU B  70
ILE B 152
LEU B 143
GLY B 118
ALA B 168
 None
 1.16A 6qxsD-5kswB:
undetectable		 6qxsD-5kswB:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 5ksw DIHYDROOROTATE
DEHYDROGENASE
(Lactococcus
lactis) 		5 / 12 ILE A 283
ASN A  18
TYR A  37
ASN A 273
ALA A 266
 None
 1.08A 6r2eE-5kswA:
undetectable		 6r2eE-5kswA:
22.25