SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kte'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 5kte DIVALENT METAL
CATION TRANSPORTER
MNTH
(Deinococcus
radiodurans) 		3 / 3 ALA A 419
VAL A 417
TRP A 416
 None
 0.81A 1bdwA-5kteA:
undetectable
1bdwB-5kteA:
undetectable		 1bdwA-5kteA:
3.54
1bdwB-5kteA:
3.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5kte DIVALENT METAL
CATION TRANSPORTER
MNTH
(Deinococcus
radiodurans) 		5 / 9 ALA A 300
PHE A  60
SER A 277
ILE A 274
ILE A 186
 None
 1.24A 1j3jB-5kteA:
undetectable		 1j3jB-5kteA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5kte DIVALENT METAL
CATION TRANSPORTER
MNTH
(Deinococcus
radiodurans) 		5 / 12 VAL A 160
LEU A 325
SER A 323
LEU A 320
THR A 161
 None
 1.32A 1kw0A-5kteA:
undetectable		 1kw0A-5kteA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5kte DIVALENT METAL
CATION TRANSPORTER
MNTH
(Deinococcus
radiodurans) 		5 / 11 VAL A 160
LEU A 325
SER A 323
LEU A 320
THR A 161
 None
 1.25A 1mmtA-5kteA:
undetectable		 1mmtA-5kteA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5kte DIVALENT METAL
CATION TRANSPORTER
MNTH
(Deinococcus
radiodurans) 		5 / 12 SER A 328
LEU A 374
GLY A 137
ALA A 138
LEU A 321
 None
 0.91A 1pxxC-5kteA:
undetectable		 1pxxC-5kteA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 5kte DIVALENT METAL
CATION TRANSPORTER
MNTH
(Deinococcus
radiodurans) 		4 / 4 GLY A 324
SER A 328
VAL A 179
LEU A 321
 None
 1.18A 1yajB-5kteA:
undetectable		 1yajB-5kteA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 5kte DIVALENT METAL
CATION TRANSPORTER
MNTH
(Deinococcus
radiodurans) 		4 / 6 SER A 372
SER A 371
ASP A 296
ASP A 369
 None
 1.17A 2j2pE-5kteA:
undetectable
2j2pF-5kteA:
undetectable		 2j2pE-5kteA:
18.08
2j2pF-5kteA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 5kte DIVALENT METAL
CATION TRANSPORTER
MNTH
(Deinococcus
radiodurans) 		4 / 5 ALA A  80
TRP A  76
LEU A  75
ALA A  81
 None
 1.20A 2jstA-5kteA:
undetectable
2jstB-5kteA:
undetectable		 2jstA-5kteA:
8.63
2jstB-5kteA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 5kte DIVALENT METAL
CATION TRANSPORTER
MNTH
(Deinococcus
radiodurans) 		4 / 7 ALA A 129
THR A 130
ALA A 133
PRO A 231
 None
 0.60A 2ql8A-5kteA:
2.2
2ql8B-5kteA:
undetectable		 2ql8A-5kteA:
14.00
2ql8B-5kteA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5kte DIVALENT METAL
CATION TRANSPORTER
MNTH
(Deinococcus
radiodurans) 		5 / 10 ILE A 422
ILE A 423
VAL A 379
GLY A 223
TYR A  70
 None
 1.29A 3em0A-5kteA:
undetectable		 3em0A-5kteA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5kte DIVALENT METAL
CATION TRANSPORTER
MNTH
(Deinococcus
radiodurans) 		3 / 3 VAL A 179
VAL A 330
SER A 328
 None
 0.64A 3n8xB-5kteA:
undetectable		 3n8xB-5kteA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5kte DIVALENT METAL
CATION TRANSPORTER
MNTH
(Deinococcus
radiodurans) 		5 / 10 ALA A 300
PHE A  60
SER A 277
ILE A 274
ILE A 186
 None
 1.26A 3qgtB-5kteA:
undetectable		 3qgtB-5kteA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5kte DIVALENT METAL
CATION TRANSPORTER
MNTH
(Deinococcus
radiodurans) 		3 / 3 HIS A 232
SER A 377
ASN A  59
 None
 0.77A 3s8pB-5kteA:
undetectable		 3s8pB-5kteA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 5kte FAB HEAVY CHAIN
(Mus
musculus) 		4 / 7 PRO H 120
GLU H 149
ASP H  88
THR H  90
 None
 1.27A 4uacA-5kteH:
undetectable		 4uacA-5kteH:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5kte DIVALENT METAL
CATION TRANSPORTER
MNTH
(Deinococcus
radiodurans) 		3 / 3 HIS A 232
SER A 377
ASN A  59
 None
 0.84A 5cprB-5kteA:
undetectable		 5cprB-5kteA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5kte DIVALENT METAL
CATION TRANSPORTER
MNTH
(Deinococcus
radiodurans) 		5 / 12 GLY A 223
LEU A 374
ILE A 423
GLY A 216
GLY A 295
 None
 1.04A 5d4uA-5kteA:
undetectable		 5d4uA-5kteA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5kte DIVALENT METAL
CATION TRANSPORTER
MNTH
(Deinococcus
radiodurans) 		5 / 12 GLY A 223
LEU A 374
ILE A 423
GLY A 216
GLY A 295
 None
 1.05A 5d4uB-5kteA:
undetectable		 5d4uB-5kteA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5kte DIVALENT METAL
CATION TRANSPORTER
MNTH
(Deinococcus
radiodurans) 		5 / 12 GLY A 223
LEU A 374
ILE A 423
GLY A 216
GLY A 295
 None
 1.01A 5d4uC-5kteA:
undetectable		 5d4uC-5kteA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 5kte DIVALENT METAL
CATION TRANSPORTER
MNTH
(Deinococcus
radiodurans) 		5 / 12 THR A 130
LEU A 132
ALA A 133
LEU A 376
GLY A 226
 None
 0.62A 5gs4A-5kteA:
undetectable		 5gs4A-5kteA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 5kte DIVALENT METAL
CATION TRANSPORTER
MNTH
FAB HEAVY CHAIN
(Deinococcus
radiodurans;
Mus
musculus) 		4 / 7 THR H  30
ASP H  54
TYR A  70
GLY A 216
 None
 1.02A 5hwaA-5kteH:
undetectable		 5hwaA-5kteH:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5kte DIVALENT METAL
CATION TRANSPORTER
MNTH
(Deinococcus
radiodurans) 		5 / 12 SER A 328
LEU A 374
GLY A 137
ALA A 138
LEU A 321
 None
 0.95A 5iktA-5kteA:
undetectable		 5iktA-5kteA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MQT_A_STIA302_1
(DEOXYCYTIDINE KINASE)		 5kte DIVALENT METAL
CATION TRANSPORTER
MNTH
(Deinococcus
radiodurans) 		5 / 12 ILE A  64
GLU A 134
PHE A 316
SER A 323
GLU A  65
 None
 1.31A 5mqtA-5kteA:
undetectable		 5mqtA-5kteA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 5kte DIVALENT METAL
CATION TRANSPORTER
MNTH
(Deinococcus
radiodurans) 		5 / 12 GLY A 324
MET A 150
THR A 157
VAL A 160
LEU A 374
 None
 0.94A 5nz0A-5kteA:
undetectable		 5nz0A-5kteA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 5kte DIVALENT METAL
CATION TRANSPORTER
MNTH
(Deinococcus
radiodurans) 		5 / 12 GLU A  65
LEU A  74
ILE A 224
VAL A 379
CYH A 382
 None
 1.19A 5vlmB-5kteA:
undetectable		 5vlmB-5kteA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 5kte DIVALENT METAL
CATION TRANSPORTER
MNTH
(Deinococcus
radiodurans) 		5 / 11 THR A 228
VAL A 390
LEU A 389
ALA A  81
VAL A 420
 None
 1.35A 6dryA-5kteA:
undetectable		 6dryA-5kteA:
22.20