SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ktk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 5ktk POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		5 / 10 GLU A 398
ALA A 397
MET A 135
LEU A 125
GLU A 126
 None
 1.28A 1a29A-5ktkA:
undetectable		 1a29A-5ktkA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_B_803B311_1
(ANTIGEN CD11A (P180))		 5ktk POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		4 / 7 VAL A 367
LEU A 221
LEU A 441
LEU A 444
 None
 0.87A 1cqpA-5ktkA:
3.3
1cqpB-5ktkA:
3.4		 1cqpA-5ktkA:
15.90
1cqpB-5ktkA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 5ktk POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		5 / 11 PHE A 366
ILE A 406
LEU A 368
MET A 393
LEU A 295
 None
None
None
None
NDP  A 601 ( 4.8A)
 1.05A 1dtlA-5ktkA:
undetectable		 1dtlA-5ktkA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 5ktk POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		4 / 7 ASP A 385
SER A 373
SER A 391
ASN A 390
 None
None
None
NDP  A 601 ( 4.5A)
 1.17A 1ig3A-5ktkA:
undetectable
1ig3B-5ktkA:
2.5		 1ig3A-5ktkA:
17.62
1ig3B-5ktkA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5ktk POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		5 / 11 LEU A 107
ALA A 387
ALA A 384
TYR A 144
LEU A 154
 None
 1.34A 1iiuA-5ktkA:
undetectable		 1iiuA-5ktkA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_A_FK5A301_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 5ktk POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		5 / 9 TYR A 144
ASP A  86
LEU A 143
VAL A 108
ILE A  64
 None
 1.39A 1q6iA-5ktkA:
undetectable		 1q6iA-5ktkA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 5ktk POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		5 / 11 ALA A  40
LEU A 147
LEU A 154
LEU A 107
LEU A 118
 None
 1.12A 2ceoA-5ktkA:
undetectable		 2ceoA-5ktkA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5ktk POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		5 / 12 THR A 250
PHE A 238
LEU A 221
ALA A 322
VAL A 367
 None
None
None
NDP  A 601 (-3.5A)
None
 1.36A 2g72A-5ktkA:
6.1		 2g72A-5ktkA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PWS_A_IBPA3960_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5ktk POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		4 / 4 LEU A 351
ILE A 406
TRP A 411
LYS A 347
 None
None
None
NDP  A 601 (-2.8A)
 1.39A 2pwsA-5ktkA:
0.0		 2pwsA-5ktkA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 5ktk POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		3 / 3 ARG A 194
SER A 180
TYR A 189
 None
 0.56A 2q2hA-5ktkA:
undetectable
2q2hB-5ktkA:
undetectable		 2q2hA-5ktkA:
13.65
2q2hB-5ktkA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 5ktk POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		5 / 10 ALA A  40
LEU A 147
LEU A 154
LEU A 107
LEU A 118
 None
 1.17A 2xn6A-5ktkA:
undetectable
2xn6B-5ktkA:
undetectable		 2xn6A-5ktkA:
19.73
2xn6B-5ktkA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5ktk POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		5 / 12 LEU A 107
VAL A 108
ASP A  86
VAL A  87
TYR A 144
 None
 1.32A 2y00A-5ktkA:
undetectable		 2y00A-5ktkA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5ktk POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		5 / 12 LEU A 107
VAL A 108
ASP A  86
VAL A  87
TYR A 144
 None
 1.31A 2y00B-5ktkA:
undetectable		 2y00B-5ktkA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5ktk POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		5 / 12 LEU A 107
VAL A 108
ASP A  86
VAL A  87
TYR A 144
 None
 1.31A 2y01B-5ktkA:
undetectable		 2y01B-5ktkA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 5ktk POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		4 / 5 VAL A 409
VAL A 456
GLN A 401
PHE A 365
 None
 1.24A 3bjwH-5ktkA:
undetectable		 3bjwH-5ktkA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 5ktk POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		4 / 5 VAL A 409
VAL A 456
GLN A 401
PHE A 365
 None
 1.22A 3bjwB-5ktkA:
undetectable		 3bjwB-5ktkA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 5ktk POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		3 / 3 ASN A 462
ASP A 429
GLN A 425
 None
 0.77A 3eeyC-5ktkA:
7.5		 3eeyC-5ktkA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 5ktk POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		3 / 3 ASN A 462
ASP A 429
GLN A 425
 None
 0.78A 3eeyD-5ktkA:
7.4		 3eeyD-5ktkA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 5ktk POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		3 / 3 ASN A 462
ASP A 429
GLN A 425
 None
 0.76A 3eeyE-5ktkA:
7.3		 3eeyE-5ktkA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 5ktk POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		4 / 6 GLY A 111
THR A  38
GLU A 109
GLU A 102
 None
 1.05A 3fpjA-5ktkA:
5.2		 3fpjA-5ktkA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5ktk POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		4 / 4 LEU A 232
GLY A 231
GLY A 229
THR A 417
 None
None
NDP  A 601 (-3.3A)
None
 0.95A 3si7A-5ktkA:
undetectable		 3si7A-5ktkA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 5ktk POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		4 / 5 HIS A 158
TRP A  24
LEU A 173
ASP A 191
 None
 1.19A 4aqlA-5ktkA:
undetectable		 4aqlA-5ktkA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 5ktk POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		4 / 7 SER A 371
GLN A 383
TYR A 386
MET A 419
 NDP  A 601 ( 4.0A)
None
NDP  A 601 (-4.4A)
NDP  A 601 (-3.7A)
 0.58A 4hxyB-5ktkA:
36.7		 4hxyB-5ktkA:
28.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 5ktk POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		3 / 3 LYS A 284
LEU A 281
ALA A 283
 None
 0.70A 4ikiA-5ktkA:
undetectable		 4ikiA-5ktkA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTQ_A_FLPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5ktk POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		5 / 10 VAL A 248
VAL A 220
ILE A 315
LEU A 295
LEU A 354
 None
None
None
NDP  A 601 ( 4.8A)
None
 1.44A 4jtqA-5ktkA:
undetectable		 4jtqA-5ktkA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 5ktk POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		3 / 3 MET A 388
MET A 472
TYR A 144
 None
 1.36A 4p6xI-5ktkA:
undetectable		 4p6xI-5ktkA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5ktk POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		5 / 12 HIS A 153
GLU A 150
GLU A 109
LEU A 116
LEU A 154
 None
 1.36A 4pgfB-5ktkA:
4.9		 4pgfB-5ktkA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5ktk POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		3 / 3 ASP A 328
ARG A 228
ARG A 252
 None
NDP  A 601 (-3.3A)
NDP  A 601 (-3.7A)
 0.89A 4x5iA-5ktkA:
undetectable		 4x5iA-5ktkA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 5ktk POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		5 / 12 LEU A 351
GLY A 323
ALA A 322
THR A 224
VAL A 318
 None
NDP  A 601 (-3.5A)
NDP  A 601 (-3.5A)
None
None
 1.00A 4xdrA-5ktkA:
undetectable		 4xdrA-5ktkA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5ktk POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		4 / 5 THR A 122
GLY A 137
GLU A 398
ASP A 160
 None
 1.16A 5c0oH-5ktkA:
5.7		 5c0oH-5ktkA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)		 5ktk POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		4 / 7 GLY A 323
ALA A 322
GLY A 231
ILE A 230
 NDP  A 601 (-3.5A)
NDP  A 601 (-3.5A)
None
NDP  A 601 (-4.0A)
 0.70A 5kqyB-5ktkA:
undetectable		 5kqyB-5ktkA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 5ktk POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		4 / 7 ILE A 319
PHE A 365
ASP A 445
SER A 212
 None
 1.40A 5nr3A-5ktkA:
undetectable		 5nr3A-5ktkA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 5ktk POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		4 / 5 HIS A 400
HIS A 357
LEU A 295
VAL A 301
 None
None
NDP  A 601 ( 4.8A)
None
 1.13A 6bc9A-5ktkA:
undetectable		 6bc9A-5ktkA:
7.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 5ktk POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		5 / 12 LEU A 221
LEU A 247
GLY A 231
GLY A 226
GLY A 251
 None
None
None
NDP  A 601 ( 4.9A)
NDP  A 601 (-3.6A)
 1.11A 6ce2B-5ktkA:
undetectable		 6ce2B-5ktkA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 5ktk POLYKETIDE SYNTHASE
PKSJ
(Bacillus
subtilis) 		4 / 8 GLY A 111
LEU A  84
GLY A  83
LEU A 116
 None
 0.70A 6mdqA-5ktkA:
undetectable		 6mdqA-5ktkA:
10.49