SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ktl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 5ktl 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Trichormus
variabilis) 		4 / 7 VAL A 213
LEU A 293
LEU A 259
VAL A 208
 None
 0.82A 1jgsA-5ktlA:
undetectable		 1jgsA-5ktlA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5ktl 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Trichormus
variabilis) 		5 / 9 GLY A 162
GLY A   5
PHE A   4
LEU A   8
GLY A 204
 None
 1.00A 1jhoA-5ktlA:
undetectable		 1jhoA-5ktlA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5ktl 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Trichormus
variabilis) 		5 / 9 GLY A 162
GLY A   5
PHE A   4
LEU A   8
GLY A 204
 None
 0.99A 1jhrA-5ktlA:
2.2		 1jhrA-5ktlA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5ktl 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Trichormus
variabilis) 		5 / 9 GLY A 162
GLY A   5
PHE A   4
LEU A   8
GLY A 204
 None
 0.96A 1jhyA-5ktlA:
undetectable		 1jhyA-5ktlA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5ktl 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Trichormus
variabilis) 		5 / 9 GLY A 162
GLY A   5
PHE A   4
LEU A   8
GLY A 204
 None
 0.96A 1l4nA-5ktlA:
undetectable		 1l4nA-5ktlA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5ktl 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Trichormus
variabilis) 		5 / 9 GLY A 162
GLY A   5
PHE A   4
LEU A   8
GLY A 204
 None
 1.00A 1l5kA-5ktlA:
undetectable		 1l5kA-5ktlA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5ktl 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Trichormus
variabilis) 		5 / 9 GLY A 162
GLY A   5
PHE A   4
LEU A   8
GLY A 204
 None
 0.99A 1l5lA-5ktlA:
undetectable		 1l5lA-5ktlA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5ktl 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Trichormus
variabilis) 		5 / 9 GLY A 162
GLY A   5
PHE A   4
LEU A   8
GLY A 204
 None
 1.00A 1l5mA-5ktlA:
undetectable		 1l5mA-5ktlA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5ktl 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Trichormus
variabilis) 		5 / 12 LEU A 246
LEU A 212
THR A  47
ILE A  12
LEU A  29
 None
None
KPI  A 164 ( 3.5A)
None
None
 0.90A 1qzfA-5ktlA:
undetectable		 1qzfA-5ktlA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5ktl 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Trichormus
variabilis) 		5 / 12 LEU A 246
LEU A 212
THR A  47
ILE A  12
LEU A  29
 None
None
KPI  A 164 ( 3.5A)
None
None
 0.90A 1qzfB-5ktlA:
undetectable		 1qzfB-5ktlA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5ktl 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Trichormus
variabilis) 		5 / 12 LEU A 246
LEU A 212
THR A  47
ILE A  12
LEU A  29
 None
None
KPI  A 164 ( 3.5A)
None
None
 0.90A 1qzfC-5ktlA:
undetectable		 1qzfC-5ktlA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5ktl 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Trichormus
variabilis) 		5 / 12 LEU A 246
LEU A 212
THR A  47
ILE A  12
LEU A  29
 None
None
KPI  A 164 ( 3.5A)
None
None
 0.90A 1qzfD-5ktlA:
undetectable		 1qzfD-5ktlA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5ktl 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Trichormus
variabilis) 		5 / 12 LEU A 246
LEU A 212
THR A  47
ILE A  12
LEU A  29
 None
None
KPI  A 164 ( 3.5A)
None
None
 0.90A 1qzfE-5ktlA:
undetectable		 1qzfE-5ktlA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 5ktl 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Trichormus
variabilis) 		4 / 6 LEU A 240
LEU A 237
LEU A 195
LEU A 193
 None
 0.90A 2ab2A-5ktlA:
undetectable		 2ab2A-5ktlA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 5ktl 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Trichormus
variabilis) 		4 / 6 GLU A 165
SER A 147
GLN A 114
ASP A 171
 None
 1.29A 2cl5B-5ktlA:
undetectable		 2cl5B-5ktlA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5ktl 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Trichormus
variabilis) 		5 / 12 LEU A 246
LEU A 212
THR A  47
ILE A  12
LEU A  29
 None
None
KPI  A 164 ( 3.5A)
None
None
 1.06A 2oipA-5ktlA:
undetectable		 2oipA-5ktlA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5ktl 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Trichormus
variabilis) 		5 / 12 LEU A 246
LEU A 212
THR A  47
ILE A  12
LEU A  29
 None
None
KPI  A 164 ( 3.5A)
None
None
 0.93A 2oipD-5ktlA:
undetectable		 2oipD-5ktlA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5ktl 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Trichormus
variabilis) 		5 / 12 LEU A 246
LEU A 212
THR A  47
ILE A  12
LEU A  29
 None
None
KPI  A 164 ( 3.5A)
None
None
 0.83A 2oipE-5ktlA:
undetectable		 2oipE-5ktlA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 5ktl 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Trichormus
variabilis) 		4 / 6 GLN A 282
LEU A 284
GLU A 285
LEU A 261
 None
 0.89A 3h5gA-5ktlA:
undetectable
3h5gC-5ktlA:
undetectable		 3h5gA-5ktlA:
5.79
3h5gC-5ktlA:
5.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 5ktl 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Trichormus
variabilis) 		4 / 6 LEU A 261
GLN A 282
LEU A 284
GLU A 285
 None
 0.92A 3h5gB-5ktlA:
undetectable
3h5gC-5ktlA:
undetectable		 3h5gB-5ktlA:
5.79
3h5gC-5ktlA:
5.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5ktl 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Trichormus
variabilis) 		5 / 12 LEU A 246
LEU A 212
THR A  47
ILE A  12
LEU A  29
 None
None
KPI  A 164 ( 3.5A)
None
None
 1.07A 3hj3B-5ktlA:
undetectable		 3hj3B-5ktlA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5ktl 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Trichormus
variabilis) 		5 / 12 LEU A 246
LEU A 212
THR A  47
ILE A  12
LEU A  29
 None
None
KPI  A 164 ( 3.5A)
None
None
 0.93A 3hj3D-5ktlA:
undetectable		 3hj3D-5ktlA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5ktl 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Trichormus
variabilis) 		5 / 9 SER A 210
SER A 207
GLY A 204
THR A 194
ASP A  39
 None
None
None
None
MN  A 302 (-3.4A)
 1.46A 4fxsA-5ktlA:
6.5		 4fxsA-5ktlA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5ktl 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Trichormus
variabilis) 		5 / 9 GLY A 162
GLY A   5
PHE A   4
LEU A   8
GLY A 204
 None
 1.04A 4kqiA-5ktlA:
undetectable		 4kqiA-5ktlA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 5ktl 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Trichormus
variabilis) 		5 / 12 LEU A 154
ILE A 124
HIS A 120
LEU A 134
GLY A  80
 None
None
None
KPI  A 164 ( 4.8A)
None
 1.28A 4l9qA-5ktlA:
undetectable		 4l9qA-5ktlA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5ktl 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Trichormus
variabilis) 		4 / 5 ILE A 255
LEU A 259
GLU A  49
VAL A  21
 None
 1.00A 4nkxB-5ktlA:
undetectable		 4nkxB-5ktlA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_B_SAMB303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5ktl 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Trichormus
variabilis) 		4 / 5 GLU A 165
SER A 147
GLN A 114
ASP A 171
 None
 1.32A 5fhrB-5ktlA:
2.2		 5fhrB-5ktlA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 5ktl 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE
(Trichormus
variabilis) 		3 / 3 GLY A   5
GLN A 218
LYS A 203
 None
 0.90A 5imsB-5ktlA:
undetectable		 5imsB-5ktlA:
21.99