SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ku1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 5ku1 MITOCHONDRIAL RHO
GTPASE 1
(Homo
sapiens) 		5 / 8 ILE A 192
LEU A 204
LEU A 209
PHE A 212
PHE A 217
 None
 1.33A 2vctA-5ku1A:
undetectable		 2vctA-5ku1A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 5ku1 MITOCHONDRIAL RHO
GTPASE 1
(Homo
sapiens) 		5 / 8 ILE A 192
LEU A 204
LEU A 209
PHE A 212
PHE A 217
 None
 1.33A 2vctB-5ku1A:
undetectable		 2vctB-5ku1A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 5ku1 MITOCHONDRIAL RHO
GTPASE 1
(Homo
sapiens) 		5 / 8 ILE A 192
LEU A 204
LEU A 209
PHE A 212
PHE A 217
 None
 1.43A 2vctC-5ku1A:
undetectable		 2vctC-5ku1A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 5ku1 MITOCHONDRIAL RHO
GTPASE 1
(Homo
sapiens) 		3 / 3 LYS A 315
ILE A 215
PHE A 217
 None
 0.99A 3j7zS-5ku1A:
undetectable
3j7za-5ku1A:
undetectable		 3j7zS-5ku1A:
13.70
3j7za-5ku1A:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5ku1 MITOCHONDRIAL RHO
GTPASE 1
(Homo
sapiens) 		4 / 8 TYR A 306
THR A 299
TYR A 470
LEU A 372
 None
 1.30A 3wipG-5ku1A:
undetectable
3wipH-5ku1A:
undetectable		 3wipG-5ku1A:
20.29
3wipH-5ku1A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5ku1 MITOCHONDRIAL RHO
GTPASE 1
(Homo
sapiens) 		3 / 3 ASP A 296
LYS A 405
ASP A 404
 None
 0.75A 4a7tA-5ku1A:
undetectable		 4a7tA-5ku1A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5ku1 MITOCHONDRIAL RHO
GTPASE 1
(Homo
sapiens) 		4 / 6 ASN A 500
GLU A 537
GLU A 505
TYR A 506
 None
 1.08A 4mi4A-5ku1A:
undetectable		 4mi4A-5ku1A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5ku1 MITOCHONDRIAL RHO
GTPASE 1
(Homo
sapiens) 		4 / 7 ASN A 500
GLU A 537
GLU A 505
TYR A 506
 None
 1.11A 4mi4B-5ku1A:
undetectable
4mi4C-5ku1A:
undetectable		 4mi4B-5ku1A:
18.57
4mi4C-5ku1A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5ku1 MITOCHONDRIAL RHO
GTPASE 1
(Homo
sapiens) 		4 / 7 ASN A 500
GLU A 537
GLU A 505
TYR A 506
 None
 1.10A 4mi4A-5ku1A:
undetectable
4mi4C-5ku1A:
undetectable		 4mi4A-5ku1A:
18.57
4mi4C-5ku1A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5ku1 MITOCHONDRIAL RHO
GTPASE 1
(Homo
sapiens) 		4 / 8 ASN A 500
GLU A 537
GLU A 505
TYR A 506
 None
 1.08A 4mj8A-5ku1A:
undetectable
4mj8C-5ku1A:
undetectable		 4mj8A-5ku1A:
16.98
4mj8C-5ku1A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5ku1 MITOCHONDRIAL RHO
GTPASE 1
(Homo
sapiens) 		4 / 8 ASN A 500
GLU A 537
GLU A 505
TYR A 506
 None
 1.12A 4mj8B-5ku1A:
undetectable
4mj8C-5ku1A:
undetectable		 4mj8B-5ku1A:
16.98
4mj8C-5ku1A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 5ku1 MITOCHONDRIAL RHO
GTPASE 1
(Homo
sapiens) 		3 / 3 VAL A 434
GLN A 555
CYH A 493
 None
 0.92A 5icxC-5ku1A:
undetectable
5icxF-5ku1A:
undetectable		 5icxC-5ku1A:
17.17
5icxF-5ku1A:
3.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 5ku1 MITOCHONDRIAL RHO
GTPASE 1
(Homo
sapiens) 		3 / 3 TYR A 470
TYR A 359
GLN A 360
 None
 0.93A 5jsdA-5ku1A:
undetectable
5jsdB-5ku1A:
undetectable		 5jsdA-5ku1A:
19.53
5jsdB-5ku1A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 5ku1 MITOCHONDRIAL RHO
GTPASE 1
(Homo
sapiens) 		3 / 3 TYR A 470
TYR A 359
GLN A 360
 None
 0.93A 5jsdB-5ku1A:
undetectable
5jsdC-5ku1A:
undetectable		 5jsdB-5ku1A:
19.53
5jsdC-5ku1A:
19.53