SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ku5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UWL_D_FOZD316_0 (THYMIDYLATE SYNTHASE)	5ku5	SENSOR KINASE CUSS (Escherichia coli)	5 / 12	LEU A 153 LEU A 127 GLY A 123 ILE A 48 ALA A 44	None	1.08A	3uwlD-5ku5A: undetectable	3uwlD-5ku5A: 18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IFU_A_GBMA801_1 (PROLINE--TRNA LIGASE)	5ku5	SENSOR KINASE CUSS (Escherichia coli)	5 / 12	LEU A 62 ARG A 108 ILE A 88 ILE A 169 MET A 150	None	1.26A	5ifuA-5ku5A: undetectable	5ifuA-5ku5A: 14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FGD_A_ACTA826_0 (GEPHYRIN)	5ku5	SENSOR KINASE CUSS (Escherichia coli)	3 / 3	HIS A 176 ARG A 149 ILE A 173	AG A 202 (-3.4A) None None	0.88A	6fgdA-5ku5A: undetectable	6fgdA-5ku5A: 16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6G1P_B_ACTB403_0 (ADP-RIBOSYLHYDROLASE LIKE 2)	5ku5	SENSOR KINASE CUSS (Escherichia coli)	3 / 3	PHE A 43 ARG A 149 GLN A 46	AG A 202 (-3.2A) None None	1.17A	6g1pB-5ku5A: undetectable	6g1pB-5ku5A: 18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6QXS_B_FOZB403_0 (THYMIDYLATE SYNTHASE)	5ku5	SENSOR KINASE CUSS (Escherichia coli)	5 / 12	LEU A 153 ILE A 151 LEU A 127 GLY A 123 ILE A 48	None	1.08A	6qxsB-5ku5A: undetectable	6qxsB-5ku5A: 18.81

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3UWL_D_FOZD316_0","THYMIDYLATE SYNTHASE","5ku5","SENSOR KINASE CUSS","Escherichia coli",5,"LEU A 153;LEU A 127;GLY A 123;ILE A  48;ALA A  44","None","1.08A","3uwlD-5ku5A:undetectable","3uwlD-5ku5A:18.81"],["5IFU_A_GBMA801_1","PROLINE--TRNA LIGASE","5ku5","SENSOR KINASE CUSS","Escherichia coli",5,"LEU A  62;ARG A 108;ILE A  88;ILE A 169;MET A 150","None","1.26A","5ifuA-5ku5A:undetectable","5ifuA-5ku5A:14.58"],["6FGD_A_ACTA826_0","GEPHYRIN","5ku5","SENSOR KINASE CUSS","Escherichia coli",3,"HIS A 176;ARG A 149;ILE A 173"," AG A 202 (-3.4A);None;None","0.88A","6fgdA-5ku5A:undetectable","6fgdA-5ku5A:16.43"],["6G1P_B_ACTB403_0","ADP-RIBOSYLHYDROLASE LIKE 2","5ku5","SENSOR KINASE CUSS","Escherichia coli",3,"PHE A  43;ARG A 149;GLN A  46"," AG A 202 (-3.2A);None;None","1.17A","6g1pB-5ku5A:undetectable","6g1pB-5ku5A:18.48"],["6QXS_B_FOZB403_0","THYMIDYLATE SYNTHASE","5ku5","SENSOR KINASE CUSS","Escherichia coli",5,"LEU A 153;ILE A 151;LEU A 127;GLY A 123;ILE A  48","None","1.08A","6qxsB-5ku5A:undetectable","6qxsB-5ku5A:18.81"]]