SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kuc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 5kuc PESTICIDAL CRYSTAL
PROTEIN CRY6AA
(Bacillus
thuringiensis) 		3 / 3 ALA A 113
VAL A 373
TRP A 370
 None
 0.94A 1jnoA-5kucA:
undetectable		 1jnoA-5kucA:
2.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 5kuc PESTICIDAL CRYSTAL
PROTEIN CRY6AA
(Bacillus
thuringiensis) 		3 / 3 ALA A 113
VAL A 373
TRP A 370
 None
 0.93A 1jnoB-5kucA:
undetectable		 1jnoB-5kucA:
2.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 5kuc PESTICIDAL CRYSTAL
PROTEIN CRY6AA
(Bacillus
thuringiensis) 		3 / 3 ALA A 113
VAL A 373
TRP A 370
 None
 0.87A 1magA-5kucA:
undetectable		 1magA-5kucA:
2.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 5kuc PESTICIDAL CRYSTAL
PROTEIN CRY6AA
(Bacillus
thuringiensis) 		3 / 3 ALA A 113
VAL A 373
TRP A 370
 None
 0.87A 1magB-5kucA:
undetectable		 1magB-5kucA:
2.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA6_0
(GRAMICIDIN A)		 5kuc PESTICIDAL CRYSTAL
PROTEIN CRY6AA
(Bacillus
thuringiensis) 		3 / 3 ALA A 113
VAL A 373
TRP A 370
 None
 0.93A 1nrmA-5kucA:
undetectable		 1nrmA-5kucA:
2.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB6_0
(GRAMICIDIN A)		 5kuc PESTICIDAL CRYSTAL
PROTEIN CRY6AA
(Bacillus
thuringiensis) 		3 / 3 ALA A 113
VAL A 373
TRP A 370
 None
 0.92A 1nrmB-5kucA:
undetectable		 1nrmB-5kucA:
2.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 5kuc PESTICIDAL CRYSTAL
PROTEIN CRY6AA
(Bacillus
thuringiensis) 		3 / 3 ALA A 113
VAL A 373
TRP A 370
 None
 0.92A 1nruA-5kucA:
undetectable		 1nruA-5kucA:
2.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 5kuc PESTICIDAL CRYSTAL
PROTEIN CRY6AA
(Bacillus
thuringiensis) 		3 / 3 ALA A 113
VAL A 373
TRP A 370
 None
 0.92A 1nruB-5kucA:
undetectable		 1nruB-5kucA:
2.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5kuc PESTICIDAL CRYSTAL
PROTEIN CRY6AA
(Bacillus
thuringiensis) 		4 / 5 ILE A 112
ILE A 339
ILE A 331
MET A  31
 None
 0.93A 1zgyA-5kucA:
2.1		 1zgyA-5kucA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 5kuc PESTICIDAL CRYSTAL
PROTEIN CRY6AA
(Bacillus
thuringiensis) 		4 / 6 LEU A 256
ASN A 313
GLN A  42
ILE A 267
 None
 1.22A 2jn3A-5kucA:
undetectable		 2jn3A-5kucA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 5kuc PESTICIDAL CRYSTAL
PROTEIN CRY6AA
(Bacillus
thuringiensis) 		4 / 7 TYR A 130
VAL A 119
TYR A 115
ILE A 339
 None
 1.17A 2x45B-5kucA:
undetectable		 2x45B-5kucA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 5kuc PESTICIDAL CRYSTAL
PROTEIN CRY6AA
(Bacillus
thuringiensis) 		4 / 7 TYR A 130
VAL A 119
TYR A 115
ILE A 339
 None
 1.14A 2x45C-5kucA:
undetectable		 2x45C-5kucA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 5kuc PESTICIDAL CRYSTAL
PROTEIN CRY6AA
(Bacillus
thuringiensis) 		5 / 12 PHE A 186
GLY A 189
ILE A 200
ASN A 199
ASP A  90
 None
 0.88A 2zzmA-5kucA:
undetectable		 2zzmA-5kucA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 5kuc PESTICIDAL CRYSTAL
PROTEIN CRY6AA
(Bacillus
thuringiensis) 		5 / 12 PHE A 186
GLY A 189
ILE A 200
ASN A 199
ASP A  90
 None
 0.96A 2zznA-5kucA:
undetectable		 2zznA-5kucA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 5kuc PESTICIDAL CRYSTAL
PROTEIN CRY6AA
(Bacillus
thuringiensis) 		5 / 10 PHE A 186
GLY A 189
ILE A 200
ASN A 199
ASP A  90
 None
 0.83A 3ay0B-5kucA:
undetectable		 3ay0B-5kucA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 5kuc PESTICIDAL CRYSTAL
PROTEIN CRY6AA
(Bacillus
thuringiensis) 		4 / 7 TYR A 130
VAL A 119
TYR A 115
ILE A 339
 None
 1.24A 3bu1A-5kucA:
undetectable		 3bu1A-5kucA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5kuc PESTICIDAL CRYSTAL
PROTEIN CRY6AA
(Bacillus
thuringiensis) 		6 / 12 ILE A 301
ALA A 214
SER A  75
ILE A  76
LEU A  64
ILE A 300
 None
 1.49A 3drcA-5kucA:
undetectable		 3drcA-5kucA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 5kuc PESTICIDAL CRYSTAL
PROTEIN CRY6AA
(Bacillus
thuringiensis) 		5 / 12 ASN A  21
SER A  22
ASP A  30
ASP A 379
THR A  32
 None
 1.30A 3lpsA-5kucA:
undetectable		 3lpsA-5kucA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 5kuc PESTICIDAL CRYSTAL
PROTEIN CRY6AA
(Bacillus
thuringiensis) 		3 / 3 ARG A 161
LYS A 128
LYS A 133
 None
 1.45A 4k50A-5kucA:
undetectable		 4k50A-5kucA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 5kuc PESTICIDAL CRYSTAL
PROTEIN CRY6AA
(Bacillus
thuringiensis) 		5 / 11 ILE A 301
ALA A 214
SER A  75
ILE A  76
LEU A  64
 None
 1.21A 4qi9C-5kucA:
undetectable		 4qi9C-5kucA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 5kuc PESTICIDAL CRYSTAL
PROTEIN CRY6AA
(Bacillus
thuringiensis) 		5 / 12 SER A  71
ILE A  76
PRO A  77
ASP A  79
ILE A 300
 None
 1.35A 4uroD-5kucA:
undetectable		 4uroD-5kucA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5kuc PESTICIDAL CRYSTAL
PROTEIN CRY6AA
(Bacillus
thuringiensis) 		4 / 4 TYR A 130
LYS A 118
GLU A 168
TYR A 115
 None
 1.44A 4w5rA-5kucA:
0.0		 4w5rA-5kucA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 5kuc PESTICIDAL CRYSTAL
PROTEIN CRY6AA
(Bacillus
thuringiensis) 		4 / 8 MET A 303
ARG A 203
HIS A  67
LEU A  64
 None
 1.03A 5dxeA-5kucA:
3.1		 5dxeA-5kucA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 5kuc PESTICIDAL CRYSTAL
PROTEIN CRY6AA
(Bacillus
thuringiensis) 		3 / 3 MET A 303
HIS A  67
GLY A 261
 None
 0.81A 5gwzB-5kucA:
undetectable		 5gwzB-5kucA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 5kuc PESTICIDAL CRYSTAL
PROTEIN CRY6AA
(Bacillus
thuringiensis) 		5 / 11 PHE A 186
GLY A 189
ILE A 200
ASN A 199
ASP A  90
 None
 0.81A 5hjiA-5kucA:
undetectable		 5hjiA-5kucA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5kuc PESTICIDAL CRYSTAL
PROTEIN CRY6AA
(Bacillus
thuringiensis) 		4 / 5 TYR A 130
LYS A 118
GLU A 168
TYR A 115
 None
 1.43A 5js1A-5kucA:
undetectable		 5js1A-5kucA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5kuc PESTICIDAL CRYSTAL
PROTEIN CRY6AA
(Bacillus
thuringiensis) 		4 / 9 TYR A 315
ILE A 311
ILE A 307
LEU A 304
 None
 0.75A 5vkqB-5kucA:
2.5
5vkqC-5kucA:
2.5		 5vkqB-5kucA:
14.41
5vkqC-5kucA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5kuc PESTICIDAL CRYSTAL
PROTEIN CRY6AA
(Bacillus
thuringiensis) 		4 / 8 MET A 303
ARG A 203
HIS A  67
LEU A  64
 None
 1.03A 6cbzA-5kucA:
3.1		 6cbzA-5kucA:
13.37