SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kuf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EUP_A_ASDA452_1 (CYTOCHROME P450ERYF)	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	4 / 8	SER A 126 ILE A 129 LEU A 130 LEU A 154	None	0.88A	1eupA-5kufA: undetectable	1eupA-5kufA: 19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	5 / 10	LEU A 435 VAL A 735 GLY A 734 LEU A 760 TYR A 431	None	1.05A	1fkoA-5kufA: undetectable	1fkoA-5kufA: 20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	5 / 9	LEU A 435 VAL A 735 GLY A 734 LEU A 760 TYR A 431	None	1.07A	1ikvA-5kufA: undetectable	1ikvA-5kufA: 21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1S1X_A_NVPA999_1 (REVERSE TRANSCRIPTASE)	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	4 / 8	LEU A 435 GLY A 734 LEU A 760 TYR A 431	None	0.87A	1s1xA-5kufA: undetectable	1s1xA-5kufA: 20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HS1_B_017B203_1 (HIV-1 PROTEASE)	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	4 / 7	GLU A 365 PRO A 237 ARG A 239 GLY A 242	None	1.12A	2hs1B-5kufA: undetectable	2hs1B-5kufA: 9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VUF_B_FUAB2002_1 (SERUM ALBUMIN)	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	4 / 9	ILE A 75 ALA A 84 VAL A 87 CYH A 91	None	1.03A	2vufB-5kufA: undetectable	2vufB-5kufA: 21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3E9R_A_ACTA700_0 (PURINE-NUCLEOSIDE PHOSPHORYLASE)	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	4 / 6	GLY A 458 GLY A 657 MET A 660 ASN A 468	None SYM A 901 (-3.1A) None None	0.85A	3e9rA-5kufA: undetectable	3e9rA-5kufA: 16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3E9R_C_ACTC700_0 (PURINE-NUCLEOSIDE PHOSPHORYLASE)	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	4 / 6	GLY A 458 GLY A 657 MET A 660 ASN A 468	None SYM A 901 (-3.1A) None None	0.85A	3e9rC-5kufA: undetectable	3e9rC-5kufA: 16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FL9_A_TOPA200_1 (DIHYDROFOLATE REDUCTASE (DHFR))	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	5 / 10	ALA A 74 VAL A 303 ALA A 29 ILE A 33 LEU A 40	None	1.17A	3fl9A-5kufA: 3.7	3fl9A-5kufA: 12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FL9_F_TOPF200_1 (DIHYDROFOLATE REDUCTASE (DHFR))	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	5 / 10	ALA A 74 VAL A 303 ALA A 29 ILE A 33 LEU A 40	None	1.20A	3fl9F-5kufA: 2.7	3fl9F-5kufA: 12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LP0_A_NVPA701_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	5 / 9	LEU A 435 VAL A 735 GLY A 734 LEU A 760 TYR A 431	None	0.95A	3lp0A-5kufA: undetectable	3lp0A-5kufA: 21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LSF_H_PZIH800_0 (GLUTAMATE RECEPTOR 2)	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	5 / 8	TYR A 431 PRO A 501 MET A 503 LEU A 760 LYS A 764	None	0.95A	3lsfH-5kufA: 34.4	3lsfH-5kufA: 18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LSL_A_PZIA800_0 (GLUTAMATE RECEPTOR 2)	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	4 / 7	TYR A 431 MET A 503 LEU A 760 LYS A 764	None	0.87A	3lslA-5kufA: 34.4 3lslD-5kufA: 33.9	3lslA-5kufA: 18.46 3lslD-5kufA: 18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LSL_D_PZID800_0 (GLUTAMATE RECEPTOR 2)	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	4 / 7	TYR A 431 MET A 503 LEU A 760 LYS A 764	None	0.86A	3lslA-5kufA: 34.4 3lslD-5kufA: 33.9	3lslA-5kufA: 18.46 3lslD-5kufA: 18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LSL_G_PZIG800_0 (GLUTAMATE RECEPTOR 2)	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	4 / 6	TYR A 431 MET A 503 LEU A 760 LYS A 764	None	0.88A	3lslG-5kufA: 33.8	3lslG-5kufA: 18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MEC_A_65BA561_0 (P66 REVERSE TRANSCRIPTASE)	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	5 / 12	LEU A 435 VAL A 735 GLY A 734 LEU A 760 TYR A 431	None	0.92A	3mecA-5kufA: undetectable	3mecA-5kufA: 21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MED_A_65BA561_0 (P51 REVERSE TRANSCRIPTASE P66 REVERSE TRANSCRIPTASE)	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	5 / 12	LEU A 435 VAL A 735 GLY A 734 LEU A 760 TYR A 431	None	0.96A	3medA-5kufA: undetectable 3medB-5kufA: 2.4	3medA-5kufA: 21.15 3medB-5kufA: 20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TKD_A_CYZA266_2 (GLUTAMATE RECEPTOR 2)	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	4 / 5	ILE A 488 PRO A 501 LYS A 731 GLY A 732	None	0.70A	3tkdB-5kufA: 35.0	3tkdB-5kufA: 19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TKD_B_CYZB267_1 (GLUTAMATE RECEPTOR 2)	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	4 / 5	ILE A 488 PRO A 501 LYS A 731 GLY A 732	None	0.70A	3tkdA-5kufA: 34.9	3tkdA-5kufA: 19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UQ6_B_ADNB401_1 (ADENOSINE KINASE, PUTATIVE)	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	5 / 12	ILE A 449 LEU A 451 GLY A 430 THR A 406 LEU A 408	None	0.88A	3uq6B-5kufA: 4.9	3uq6B-5kufA: 17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VAQ_B_ADNB401_1 (PUTATIVE ADENOSINE KINASE)	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	5 / 12	ILE A 449 LEU A 451 GLY A 430 THR A 406 LEU A 408	None	0.93A	3vaqB-5kufA: 3.5	3vaqB-5kufA: 17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4E0F_A_RBFA301_1 (RIBOFLAVIN SYNTHASE SUBUNIT ALPHA)	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	5 / 11	VAL A 301 THR A 38 GLU A 338 HIS A 297 VAL A 298	None	1.17A	4e0fA-5kufA: undetectable	4e0fA-5kufA: 12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4E1G_A_LNLA701_1 (PROSTAGLANDIN G/H SYNTHASE 2)	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	5 / 12	PHE A 445 ILE A 751 GLY A 736 ALA A 482 LEU A 436	None	0.96A	4e1gA-5kufA: undetectable	4e1gA-5kufA: 20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4E1G_B_LNLB701_1 (PROSTAGLANDIN G/H SYNTHASE 2)	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	5 / 12	PHE A 445 ILE A 751 GLY A 736 ALA A 482 LEU A 436	None	0.98A	4e1gB-5kufA: undetectable	4e1gB-5kufA: 20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EIL_C_FOLC703_0 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	5 / 11	VAL A 301 PHE A 328 SER A 330 PHE A 114 VAL A 298	None	1.45A	4eilC-5kufA: 3.6	4eilC-5kufA: 20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EIL_E_FOLE703_0 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	5 / 11	VAL A 301 PHE A 328 SER A 330 PHE A 114 VAL A 298	None	1.45A	4eilE-5kufA: 3.4	4eilE-5kufA: 20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MWZ_B_CQAB303_0 (PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE, PUTATIVE)	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	4 / 8	GLY A 77 LEU A 54 GLU A 12 LYS A 51	None	0.82A	4mwzB-5kufA: undetectable	4mwzB-5kufA: 15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4POO_A_SAMA301_0 (PUTATIVE RNA METHYLASE)	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	5 / 12	THR A 373 ASN A 252 ASP A 357 ILE A 371 THR A 383	None	1.34A	4pooA-5kufA: 2.2	4pooA-5kufA: 12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QCK_A_ASDA404_1 (3-KETOSTEROID-9-ALPH A-MONOOXYGENASE OXYGENASE SUBUNIT)	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	5 / 12	HIS A 297 ALA A 289 MET A 285 LEU A 251 GLY A 339	None	1.26A	4qckA-5kufA: undetectable	4qckA-5kufA: 17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QCK_A_ASDA404_1 (3-KETOSTEROID-9-ALPH A-MONOOXYGENASE OXYGENASE SUBUNIT)	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	5 / 12	HIS A 297 LEU A 118 ALA A 289 LEU A 251 GLY A 339	None	1.33A	4qckA-5kufA: undetectable	4qckA-5kufA: 17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Y4D_A_CFFA411_1 (ENDOTHIAPEPSIN)	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	4 / 6	LEU A 230 LEU A 208 ILE A 196 PHE A 197	None	1.14A	4y4dA-5kufA: undetectable	4y4dA-5kufA: 17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Y8W_C_STRC603_1 (CYTOCHROME P450 21-HYDROXYLASE)	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	6 / 12	VAL A 298 ILE A 99 ILE A 344 GLY A 342 VAL A 258 LEU A 251	None	1.43A	4y8wC-5kufA: undetectable	4y8wC-5kufA: 20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZJQ_A_ERYA1101_0 (MULTIDRUG EFFLUX PUMP SUBUNIT ACRB)	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	5 / 11	SER A 658 LEU A 436 GLU A 707 GLY A 732 MET A 503	SYM A 901 (-3.4A) None SYM A 901 (-3.3A) None None	1.24A	4zjqA-5kufA: undetectable	4zjqA-5kufA: 21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JHD_E_EDTE301_0 (BETA-2-MICROGLOBULIN TCRBETA CHAIN)	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	4 / 8	SER A 658 THR A 487 THR A 489 ILE A 507	SYM A 901 (-3.4A) SYM A 901 (-3.7A) None None	1.08A	5jhdE-5kufA: undetectable 5jhdG-5kufA: undetectable	5jhdE-5kufA: 13.97 5jhdG-5kufA: 8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5K7U_A_SAMA601_0 (N6-ADENOSINE-METHYLT RANSFERASE 70 KDA SUBUNIT)	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	5 / 12	ILE A 789 PRO A 527 LEU A 624 PHE A 524 GLY A 520	None	1.14A	5k7uA-5kufA: undetectable	5k7uA-5kufA: 13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KKL_B_SAMB8009_0 (PUTATIVE UNCHARACTERIZED PROTEIN,HISTONE H3.1 PEPTIDE,ZINC FINGER DOMAIN-CONTAINING PROTEIN)	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	5 / 12	LEU A 281 GLY A 279 PHE A 225 LEU A 230 MET A 245	None	1.02A	5kklB-5kufA: undetectable	5kklB-5kufA: 22.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5L1F_A_6ZPA902_1 (GLUTAMATE RECEPTOR 2)	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	4 / 8	SER A 523 PRO A 527 TYR A 620 PHE A 627	None	1.12A	5l1fA-5kufA: 34.8 5l1fB-5kufA: 39.2	5l1fA-5kufA: 39.87 5l1fB-5kufA: 39.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5L1F_B_6ZPB902_1 (GLUTAMATE RECEPTOR 2)	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	5 / 9	SER A 523 PRO A 527 TYR A 620 LEU A 624 PHE A 627	None	1.06A	5l1fB-5kufA: 39.2	5l1fB-5kufA: 39.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L6E_B_ACTB401_0 (N6-ADENOSINE-METHYLT RANSFERASE 70 KDA SUBUNIT N6-ADENOSINE-METHYLT RANSFERASE SUBUNIT METTL14)	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	4 / 6	GLU A 192 LEU A 184 ARG A 189 ARG A 171	None	1.17A	5l6eA-5kufA: 1.7 5l6eB-5kufA: undetectable	5l6eA-5kufA: 13.89 5l6eB-5kufA: 16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LJB_A_RTLA201_0 (RETINOL-BINDING PROTEIN 1)	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	5 / 12	PHE A 76 LEU A 118 ALA A 295 ILE A 332 LEU A 5	None	1.38A	5ljbA-5kufA: undetectable	5ljbA-5kufA: 10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VLM_E_CVIE301_1 (REGULATORY PROTEIN TETR)	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	4 / 7	GLN A 210 GLY A 206 ASP A 234 ASP A 277	None	1.16A	5vlmE-5kufA: undetectable	5vlmE-5kufA: 11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	5 / 10	LEU A 435 VAL A 735 GLY A 734 LEU A 760 TYR A 431	None	0.94A	6bsgA-5kufA: undetectable	6bsgA-5kufA: 6.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	5 / 10	LEU A 435 VAL A 735 GLY A 734 LEU A 760 TYR A 431	None	1.06A	6bsiA-5kufA: undetectable	6bsiA-5kufA: 6.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DLZ_D_CYZD1302_0 (GLUTAMATE RECEPTOR 2,VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-2 SUBUNIT)	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	5 / 11	PRO A 501 MET A 503 LEU A 752 LEU A 760 LYS A 764	None	0.72A	6dlzA-5kufA: 38.3 6dlzD-5kufA: 37.8	6dlzA-5kufA: 6.53 6dlzD-5kufA: 6.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DM1_D_CYZD1302_0 (GLUTAMATE RECEPTOR 2,VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-2 SUBUNIT)	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	5 / 11	PRO A 501 MET A 503 LEU A 752 LEU A 760 LYS A 764	None	0.69A	6dm1A-5kufA: 38.3 6dm1D-5kufA: 37.8	6dm1A-5kufA: 6.53 6dm1D-5kufA: 6.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6F6N_A_SREA508_1 (ENVELOPE GLYCOPROTEIN,ENVELOP E GLYCOPROTEIN,GP1 ENVELOPE GLYCOPROTEIN)	5kuf	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Rattus norvegicus)	5 / 10	VAL A 303 ALA A 302 LEU A 40 LEU A 39 LEU A 45	None	1.01A	6f6nA-5kufA: undetectable 6f6nB-5kufA: undetectable	6f6nA-5kufA: 7.20 6f6nB-5kufA: 6.39

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1EUP_A_ASDA452_1","CYTOCHROME P450ERYF","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",4,"SER A 126;ILE A 129;LEU A 130;LEU A 154","None","0.88A","1eupA-5kufA:undetectable","1eupA-5kufA:19.75"],["1FKO_A_EFZA999_1","HIV-1 RT, A-CHAIN","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",5,"LEU A 435;VAL A 735;GLY A 734;LEU A 760;TYR A 431","None","1.05A","1fkoA-5kufA:undetectable","1fkoA-5kufA:20.88"],["1IKV_A_EFZA2000_1","POL POLYPROTEIN","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",5,"LEU A 435;VAL A 735;GLY A 734;LEU A 760;TYR A 431","None","1.07A","1ikvA-5kufA:undetectable","1ikvA-5kufA:21.75"],["1S1X_A_NVPA999_1","REVERSE TRANSCRIPTASE","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",4,"LEU A 435;GLY A 734;LEU A 760;TYR A 431","None","0.87A","1s1xA-5kufA:undetectable","1s1xA-5kufA:20.92"],["2HS1_B_017B203_1","HIV-1 PROTEASE","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",4,"GLU A 365;PRO A 237;ARG A 239;GLY A 242","None","1.12A","2hs1B-5kufA:undetectable","2hs1B-5kufA:9.30"],["2VUF_B_FUAB2002_1","SERUM ALBUMIN","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",4,"ILE A  75;ALA A  84;VAL A  87;CYH A  91","None","1.03A","2vufB-5kufA:undetectable","2vufB-5kufA:21.67"],["3E9R_A_ACTA700_0","PURINE-NUCLEOSIDE PHOSPHORYLASE","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",4,"GLY A 458;GLY A 657;MET A 660;ASN A 468","None;SYM A 901 (-3.1A);None;None","0.85A","3e9rA-5kufA:undetectable","3e9rA-5kufA:16.70"],["3E9R_C_ACTC700_0","PURINE-NUCLEOSIDE PHOSPHORYLASE","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",4,"GLY A 458;GLY A 657;MET A 660;ASN A 468","None;SYM A 901 (-3.1A);None;None","0.85A","3e9rC-5kufA:undetectable","3e9rC-5kufA:16.70"],["3FL9_A_TOPA200_1","DIHYDROFOLATE REDUCTASE (DHFR)","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",5,"ALA A  74;VAL A 303;ALA A  29;ILE A  33;LEU A  40","None","1.17A","3fl9A-5kufA:3.7","3fl9A-5kufA:12.26"],["3FL9_F_TOPF200_1","DIHYDROFOLATE REDUCTASE (DHFR)","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",5,"ALA A  74;VAL A 303;ALA A  29;ILE A  33;LEU A  40","None","1.20A","3fl9F-5kufA:2.7","3fl9F-5kufA:12.26"],["3LP0_A_NVPA701_1","REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",5,"LEU A 435;VAL A 735;GLY A 734;LEU A 760;TYR A 431","None","0.95A","3lp0A-5kufA:undetectable","3lp0A-5kufA:21.15"],["3LSF_H_PZIH800_0","GLUTAMATE RECEPTOR 2","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",5,"TYR A 431;PRO A 501;MET A 503;LEU A 760;LYS A 764","None","0.95A","3lsfH-5kufA:34.4","3lsfH-5kufA:18.46"],["3LSL_A_PZIA800_0","GLUTAMATE RECEPTOR 2","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",4,"TYR A 431;MET A 503;LEU A 760;LYS A 764","None","0.87A","3lslA-5kufA:34.4;3lslD-5kufA:33.9","3lslA-5kufA:18.46;3lslD-5kufA:18.46"],["3LSL_D_PZID800_0","GLUTAMATE RECEPTOR 2","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",4,"TYR A 431;MET A 503;LEU A 760;LYS A 764","None","0.86A","3lslA-5kufA:34.4;3lslD-5kufA:33.9","3lslA-5kufA:18.46;3lslD-5kufA:18.46"],["3LSL_G_PZIG800_0","GLUTAMATE RECEPTOR 2","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",4,"TYR A 431;MET A 503;LEU A 760;LYS A 764","None","0.88A","3lslG-5kufA:33.8","3lslG-5kufA:18.46"],["3MEC_A_65BA561_0","P66 REVERSE TRANSCRIPTASE","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",5,"LEU A 435;VAL A 735;GLY A 734;LEU A 760;TYR A 431","None","0.92A","3mecA-5kufA:undetectable","3mecA-5kufA:21.03"],["3MED_A_65BA561_0","P51 REVERSE TRANSCRIPTASE;P66 REVERSE TRANSCRIPTASE","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",5,"LEU A 435;VAL A 735;GLY A 734;LEU A 760;TYR A 431","None","0.96A","3medA-5kufA:undetectable;3medB-5kufA:2.4","3medA-5kufA:21.15;3medB-5kufA:20.34"],["3TKD_A_CYZA266_2","GLUTAMATE RECEPTOR 2;GLUTAMATE RECEPTOR 2","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",4,"ILE A 488;PRO A 501;LYS A 731;GLY A 732","None","0.70A","3tkdB-5kufA:35.0","3tkdB-5kufA:19.29"],["3TKD_B_CYZB267_1","GLUTAMATE RECEPTOR 2;GLUTAMATE RECEPTOR 2","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",4,"ILE A 488;PRO A 501;LYS A 731;GLY A 732","None","0.70A","3tkdA-5kufA:34.9","3tkdA-5kufA:19.29"],["3UQ6_B_ADNB401_1","ADENOSINE KINASE, PUTATIVE","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",5,"ILE A 449;LEU A 451;GLY A 430;THR A 406;LEU A 408","None","0.88A","3uq6B-5kufA:4.9","3uq6B-5kufA:17.48"],["3VAQ_B_ADNB401_1","PUTATIVE ADENOSINE KINASE","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",5,"ILE A 449;LEU A 451;GLY A 430;THR A 406;LEU A 408","None","0.93A","3vaqB-5kufA:3.5","3vaqB-5kufA:17.59"],["4E0F_A_RBFA301_1","RIBOFLAVIN SYNTHASE SUBUNIT ALPHA","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",5,"VAL A 301;THR A  38;GLU A 338;HIS A 297;VAL A 298","None","1.17A","4e0fA-5kufA:undetectable","4e0fA-5kufA:12.63"],["4E1G_A_LNLA701_1","PROSTAGLANDIN G\/H SYNTHASE 2","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",5,"PHE A 445;ILE A 751;GLY A 736;ALA A 482;LEU A 436","None","0.96A","4e1gA-5kufA:undetectable","4e1gA-5kufA:20.86"],["4E1G_B_LNLB701_1","PROSTAGLANDIN G\/H SYNTHASE 2","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",5,"PHE A 445;ILE A 751;GLY A 736;ALA A 482;LEU A 436","None","0.98A","4e1gB-5kufA:undetectable","4e1gB-5kufA:20.86"],["4EIL_C_FOLC703_0","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",5,"VAL A 301;PHE A 328;SER A 330;PHE A 114;VAL A 298","None","1.45A","4eilC-5kufA:3.6","4eilC-5kufA:20.38"],["4EIL_E_FOLE703_0","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",5,"VAL A 301;PHE A 328;SER A 330;PHE A 114;VAL A 298","None","1.45A","4eilE-5kufA:3.4","4eilE-5kufA:20.38"],["4MWZ_B_CQAB303_0","PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE, PUTATIVE","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",4,"GLY A  77;LEU A  54;GLU A  12;LYS A  51","None","0.82A","4mwzB-5kufA:undetectable","4mwzB-5kufA:15.57"],["4POO_A_SAMA301_0","PUTATIVE RNA METHYLASE","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",5,"THR A 373;ASN A 252;ASP A 357;ILE A 371;THR A 383","None","1.34A","4pooA-5kufA:2.2","4pooA-5kufA:12.96"],["4QCK_A_ASDA404_1","3-KETOSTEROID-9-ALPHA-MONOOXYGENASE OXYGENASE SUBUNIT","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",5,"HIS A 297;ALA A 289;MET A 285;LEU A 251;GLY A 339","None","1.26A","4qckA-5kufA:undetectable","4qckA-5kufA:17.38"],["4QCK_A_ASDA404_1","3-KETOSTEROID-9-ALPHA-MONOOXYGENASE OXYGENASE SUBUNIT","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",5,"HIS A 297;LEU A 118;ALA A 289;LEU A 251;GLY A 339","None","1.33A","4qckA-5kufA:undetectable","4qckA-5kufA:17.38"],["4Y4D_A_CFFA411_1","ENDOTHIAPEPSIN","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",4,"LEU A 230;LEU A 208;ILE A 196;PHE A 197","None","1.14A","4y4dA-5kufA:undetectable","4y4dA-5kufA:17.53"],["4Y8W_C_STRC603_1","CYTOCHROME P450 21-HYDROXYLASE","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",6,"VAL A 298;ILE A  99;ILE A 344;GLY A 342;VAL A 258;LEU A 251","None","1.43A","4y8wC-5kufA:undetectable","4y8wC-5kufA:20.34"],["4ZJQ_A_ERYA1101_0","MULTIDRUG EFFLUX PUMP SUBUNIT ACRB","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",5,"SER A 658;LEU A 436;GLU A 707;GLY A 732;MET A 503","SYM A 901 (-3.4A);None;SYM A 901 (-3.3A);None;None","1.24A","4zjqA-5kufA:undetectable","4zjqA-5kufA:21.91"],["5JHD_E_EDTE301_0","BETA-2-MICROGLOBULIN;TCRBETA CHAIN","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",4,"SER A 658;THR A 487;THR A 489;ILE A 507","SYM A 901 (-3.4A);SYM A 901 (-3.7A);None;None","1.08A","5jhdE-5kufA:undetectable;5jhdG-5kufA:undetectable","5jhdE-5kufA:13.97;5jhdG-5kufA:8.28"],["5K7U_A_SAMA601_0","N6-ADENOSINE-METHYLTRANSFERASE 70 KDA SUBUNIT","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",5,"ILE A 789;PRO A 527;LEU A 624;PHE A 524;GLY A 520","None","1.14A","5k7uA-5kufA:undetectable","5k7uA-5kufA:13.78"],["5KKL_B_SAMB8009_0","PUTATIVE UNCHARACTERIZED PROTEIN,HISTONE H3.1 PEPTIDE,ZINC FINGER DOMAIN-CONTAINING PROTEIN","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",5,"LEU A 281;GLY A 279;PHE A 225;LEU A 230;MET A 245","None","1.02A","5kklB-5kufA:undetectable","5kklB-5kufA:22.25"],["5L1F_A_6ZPA902_1","GLUTAMATE RECEPTOR 2;GLUTAMATE RECEPTOR 2","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",4,"SER A 523;PRO A 527;TYR A 620;PHE A 627","None","1.12A","5l1fA-5kufA:34.8;5l1fB-5kufA:39.2","5l1fA-5kufA:39.87;5l1fB-5kufA:39.87"],["5L1F_B_6ZPB902_1","GLUTAMATE RECEPTOR 2","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",5,"SER A 523;PRO A 527;TYR A 620;LEU A 624;PHE A 627","None","1.06A","5l1fB-5kufA:39.2","5l1fB-5kufA:39.87"],["5L6E_B_ACTB401_0","N6-ADENOSINE-METHYLTRANSFERASE 70 KDA SUBUNIT;N6-ADENOSINE-METHYLTRANSFERASE SUBUNIT METTL14","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",4,"GLU A 192;LEU A 184;ARG A 189;ARG A 171","None","1.17A","5l6eA-5kufA:1.7;5l6eB-5kufA:undetectable","5l6eA-5kufA:13.89;5l6eB-5kufA:16.63"],["5LJB_A_RTLA201_0","RETINOL-BINDING PROTEIN 1","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",5,"PHE A  76;LEU A 118;ALA A 295;ILE A 332;LEU A   5","None","1.38A","5ljbA-5kufA:undetectable","5ljbA-5kufA:10.71"],["5VLM_E_CVIE301_1","REGULATORY PROTEIN TETR","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",4,"GLN A 210;GLY A 206;ASP A 234;ASP A 277","None","1.16A","5vlmE-5kufA:undetectable","5vlmE-5kufA:11.17"],["6BSG_A_EFZA601_1","REVERSE TRANSCRIPTASE P66 SUBUNIT","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",5,"LEU A 435;VAL A 735;GLY A 734;LEU A 760;TYR A 431","None","0.94A","6bsgA-5kufA:undetectable","6bsgA-5kufA:6.81"],["6BSI_A_EFZA601_1","REVERSE TRANSCRIPTASE P66 SUBUNIT","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",5,"LEU A 435;VAL A 735;GLY A 734;LEU A 760;TYR A 431","None","1.06A","6bsiA-5kufA:undetectable","6bsiA-5kufA:6.81"],["6DLZ_D_CYZD1302_0","GLUTAMATE RECEPTOR 2,VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-2 SUBUNIT","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",5,"PRO A 501;MET A 503;LEU A 752;LEU A 760;LYS A 764","None","0.72A","6dlzA-5kufA:38.3;6dlzD-5kufA:37.8","6dlzA-5kufA:6.53;6dlzD-5kufA:6.53"],["6DM1_D_CYZD1302_0","GLUTAMATE RECEPTOR 2,VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-2 SUBUNIT","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",5,"PRO A 501;MET A 503;LEU A 752;LEU A 760;LYS A 764","None","0.69A","6dm1A-5kufA:38.3;6dm1D-5kufA:37.8","6dm1A-5kufA:6.53;6dm1D-5kufA:6.53"],["6F6N_A_SREA508_1","ENVELOPE GLYCOPROTEIN,ENVELOPE GLYCOPROTEIN,GP1;ENVELOPE GLYCOPROTEIN","5kuf","GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2","Rattus norvegicus",5,"VAL A 303;ALA A 302;LEU A  40;LEU A  39;LEU A  45","None","1.01A","6f6nA-5kufA:undetectable;6f6nB-5kufA:undetectable","6f6nA-5kufA:7.20;6f6nB-5kufA:6.39"]]