SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kum'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 5kum ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 12
(Gallus
gallus) 		5 / 11 ALA A 230
GLU A 294
ARG A  44
LEU A 317
GLU A 320
 None
 1.00A 1mjlA-5kumA:
undetectable
1mjlB-5kumA:
undetectable		 1mjlA-5kumA:
12.87
1mjlB-5kumA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5kum ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 12
(Gallus
gallus) 		5 / 12 LEU A 280
GLU A 320
ARG A  44
HIS A 272
ILE A 274
 None
 1.13A 1s9pD-5kumA:
undetectable		 1s9pD-5kumA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 5kum ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 12
(Gallus
gallus) 		4 / 6 ARG A 219
THR A 306
ALA A 305
PRO A 187
 None
 1.43A 2ql8A-5kumA:
undetectable
2ql8B-5kumA:
undetectable		 2ql8A-5kumA:
19.55
2ql8B-5kumA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5kum ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 12
(Gallus
gallus) 		3 / 3 ALA A 182
ARG A 186
LYS A 188
 None
PIO  A 401 (-3.5A)
PIO  A 401 (-2.8A)
 0.94A 3kp3B-5kumA:
2.3		 3kp3B-5kumA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5kum ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 12
(Gallus
gallus) 		3 / 3 ALA A 182
ARG A 186
LYS A 189
 None
PIO  A 401 (-3.5A)
PIO  A 401 (-2.7A)
 1.03A 3kp3B-5kumA:
2.3		 3kp3B-5kumA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 5kum ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 12
(Gallus
gallus) 		5 / 12 SER A 278
ILE A 321
ILE A 283
GLY A 282
VAL A 363
 None
 1.02A 4y8wC-5kumA:
undetectable		 4y8wC-5kumA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 5kum ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 12
(Gallus
gallus) 		5 / 12 VAL A 202
LEU A 209
ILE A 321
ILE A 283
GLY A 282
 None
 1.03A 4y8wC-5kumA:
undetectable		 4y8wC-5kumA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5kum ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 12
(Gallus
gallus) 		4 / 6 PHE A  97
MET A 161
LEU A  99
LEU A  96
 None
 1.37A 5dzke-5kumA:
undetectable
5dzks-5kumA:
undetectable		 5dzke-5kumA:
21.22
5dzks-5kumA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 5kum ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 12
(Gallus
gallus) 		4 / 6 ASN A 199
LEU A 322
ARG A 326
GLY A 324
 None
 0.85A 5o4yA-5kumA:
undetectable		 5o4yA-5kumA:
2.92