SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kut'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HK1_A_T44A3004_1 (SERUM ALBUMIN)	5kut	MITOCHONDRIAL RHO GTPASE 2 (Homo sapiens)	4 / 6	PHE A 567 PHE A 432 LEU A 520 VAL A 552	None	0.90A	1hk1A-5kutA: undetectable	1hk1A-5kutA: 15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NW3_A_SAMA500_1 (HISTONE METHYLTRANSFERASE DOT1L)	5kut	MITOCHONDRIAL RHO GTPASE 2 (Homo sapiens)	4 / 4	THR A 446 GLN A 434 GLU A 471 ASP A 475	None None MG A 602 ( 2.5A) None	1.26A	1nw3A-5kutA: undetectable	1nw3A-5kutA: 18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PFG_A_SAMA264_0 (N-METHYLTRANSFERASE)	5kut	MITOCHONDRIAL RHO GTPASE 2 (Homo sapiens)	5 / 12	GLY A 531 LEU A 528 ASP A 527 PHE A 501 SER A 523	None GDP A 601 (-4.1A) GDP A 601 (-3.0A) None None	1.32A	3pfgA-5kutA: undetectable	3pfgA-5kutA: 25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VAS_B_ADNB401_2 (PUTATIVE ADENOSINE KINASE)	5kut	MITOCHONDRIAL RHO GTPASE 2 (Homo sapiens)	4 / 5	LEU A 433 ALA A 435 MET A 492 PHE A 567	None	1.38A	3vasB-5kutA: 3.4	3vasB-5kutA: 18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WS0_A_URFA301_1 (URACIL-DNA GLYCOSYLASE)	5kut	MITOCHONDRIAL RHO GTPASE 2 (Homo sapiens)	4 / 7	GLY A 410 GLN A 411 PHE A 576 ASN A 461	None	1.12A	4ws0A-5kutA: 3.2	4ws0A-5kutA: 24.00

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1HK1_A_T44A3004_1","SERUM ALBUMIN","5kut","MITOCHONDRIAL RHO GTPASE 2","Homo sapiens",4,"PHE A 567;PHE A 432;LEU A 520;VAL A 552","None","0.90A","1hk1A-5kutA:undetectable","1hk1A-5kutA:15.38"],["1NW3_A_SAMA500_1","HISTONE METHYLTRANSFERASE DOT1L","5kut","MITOCHONDRIAL RHO GTPASE 2","Homo sapiens",4,"THR A 446;GLN A 434;GLU A 471;ASP A 475","None;None; MG A 602 ( 2.5A);None","1.26A","1nw3A-5kutA:undetectable","1nw3A-5kutA:18.18"],["3PFG_A_SAMA264_0","N-METHYLTRANSFERASE","5kut","MITOCHONDRIAL RHO GTPASE 2","Homo sapiens",5,"GLY A 531;LEU A 528;ASP A 527;PHE A 501;SER A 523","None;GDP A 601 (-4.1A);GDP A 601 (-3.0A);None;None","1.32A","3pfgA-5kutA:undetectable","3pfgA-5kutA:25.37"],["3VAS_B_ADNB401_2","PUTATIVE ADENOSINE KINASE","5kut","MITOCHONDRIAL RHO GTPASE 2","Homo sapiens",4,"LEU A 433;ALA A 435;MET A 492;PHE A 567","None","1.38A","3vasB-5kutA:3.4","3vasB-5kutA:18.21"],["4WS0_A_URFA301_1","URACIL-DNA GLYCOSYLASE","5kut","MITOCHONDRIAL RHO GTPASE 2","Homo sapiens",4,"GLY A 410;GLN A 411;PHE A 576;ASN A 461","None","1.12A","4ws0A-5kutA:3.2","4ws0A-5kutA:24.00"]]