SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kve'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 5kve ZV-48 ANTIBODY SCFV
HEAVY CHAIN
ZV-48 ANTIBODY SCFV
LIGHT CHAIN
(Mus
musculus) 		8 / 12 TYR L  36
GLN L  89
TYR L  94
PHE L  98
TRP H  33
VAL H  37
ALA H  93
TRP H 103
 None
 0.85A 1h8sA-5kveL:
20.9		 1h8sA-5kveL:
66.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5kve ZV-48 ANTIBODY SCFV
HEAVY CHAIN
ZV-48 ANTIBODY SCFV
LIGHT CHAIN
(Mus
musculus;
Mus
musculus) 		4 / 7 PRO H  45
TYR H  91
TYR L  36
TYR L  87
 None
 0.72A 2oldA-5kveH:
15.5
2oldB-5kveH:
15.6		 2oldA-5kveH:
22.52
2oldB-5kveH:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5kve ZV-48 ANTIBODY SCFV
HEAVY CHAIN
ZV-48 ANTIBODY SCFV
LIGHT CHAIN
(Mus
musculus;
Mus
musculus) 		4 / 7 TYR L  36
TYR L  87
PRO H  45
TYR H  91
 None
 0.67A 2oldA-5kveL:
17.2
2oldB-5kveL:
17.1		 2oldA-5kveL:
26.79
2oldB-5kveL:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 5kve ZV-48 ANTIBODY SCFV
LIGHT CHAIN
(Mus
musculus) 		5 / 12 VAL L  13
VAL L  58
GLN L  42
ILE L  48
PHE L  62
 None
None
SO4  L 203 (-3.3A)
None
None
 1.23A 6becA-5kveL:
undetectable
6becB-5kveL:
undetectable
6becC-5kveL:
undetectable		 6becA-5kveL:
12.17
6becB-5kveL:
12.17
6becC-5kveL:
12.17