SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kvk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 5kvk PROTEIN KP700603
(Klebsiella
pneumoniae) 		5 / 10 ALA A 102
LEU A 166
LEU A 162
LEU A  30
ARG A  26
 None
 1.08A 2xn6A-5kvkA:
undetectable
2xn6B-5kvkA:
undetectable		 2xn6A-5kvkA:
17.90
2xn6B-5kvkA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 5kvk PROTEIN KP700603
(Klebsiella
pneumoniae) 		5 / 10 ALA A 102
LEU A 166
LEU A 162
LEU A  30
ARG A  26
 None
 1.10A 2xn7A-5kvkA:
undetectable
2xn7B-5kvkA:
undetectable		 2xn7A-5kvkA:
17.90
2xn7B-5kvkA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 5kvk PROTEIN KP700603
(Klebsiella
pneumoniae) 		4 / 6 LEU A  41
ALA A 160
LEU A  15
THR A  16
 None
 1.04A 3rozA-5kvkA:
undetectable		 3rozA-5kvkA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5kvk PROTEIN KP700603
(Klebsiella
pneumoniae) 		5 / 12 ILE A 108
LEU A 162
LEU A  41
TRP A 169
ALA A 105
 None
 1.29A 4m11A-5kvkA:
undetectable		 4m11A-5kvkA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5kvk PROTEIN KP700603
(Klebsiella
pneumoniae) 		5 / 12 ILE A 108
LEU A 162
LEU A  41
TRP A 169
ALA A 105
 None
 1.33A 4m11C-5kvkA:
undetectable		 4m11C-5kvkA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5kvk PROTEIN KP700603
(Klebsiella
pneumoniae) 		5 / 9 ALA A 105
THR A  32
ALA A  33
ALA A 107
GLY A 101
 None
 1.02A 5l5zK-5kvkA:
undetectable
5l5zL-5kvkA:
undetectable		 5l5zK-5kvkA:
20.63
5l5zL-5kvkA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5kvk PROTEIN KP700603
(Klebsiella
pneumoniae) 		5 / 9 ALA A 105
THR A  32
ALA A  33
ALA A 107
GLY A 101
 None
 1.02A 5l5zY-5kvkA:
undetectable
5l5zZ-5kvkA:
undetectable		 5l5zY-5kvkA:
20.63
5l5zZ-5kvkA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 5kvk PROTEIN KP700603
(Klebsiella
pneumoniae) 		4 / 6 SER A  82
ARG A 142
ARG A 140
ASP A 119
 None
 1.03A 5zw4A-5kvkA:
undetectable		 5zw4A-5kvkA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AY4_A_TPFA506_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 5kvk PROTEIN KP700603
(Klebsiella
pneumoniae) 		5 / 10 MET A 141
PHE A 143
ALA A 154
PHE A 157
ALA A 158
 None
 1.32A 6ay4A-5kvkA:
undetectable		 6ay4A-5kvkA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5kvk PROTEIN KP700603
(Klebsiella
pneumoniae) 		3 / 3 GLY A  58
THR A  32
GLU A  34
 None
 0.66A 6b58A-5kvkA:
undetectable		 6b58A-5kvkA:
14.85