SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kvm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 5kvm ADHESION G-PROTEIN
COUPLED RECEPTOR G1
(Mus
musculus) 		4 / 4 VAL A 237
ALA A 235
LEU A 179
PHE A 228
 None
 1.15A 1q97B-5kvmA:
undetectable		 1q97B-5kvmA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 5kvm ADHESION G-PROTEIN
COUPLED RECEPTOR G1
(Mus
musculus) 		4 / 5 ILE A  77
PRO A  78
PHE A  81
ILE A  67
 None
 0.87A 2hjhA-5kvmA:
undetectable		 2hjhA-5kvmA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5kvm ADHESION G-PROTEIN
COUPLED RECEPTOR G1
(Mus
musculus) 		5 / 12 LEU A 313
SER A 253
VAL A 262
HIS A 335
LEU A 344
 None
 1.37A 2zlcA-5kvmA:
undetectable		 2zlcA-5kvmA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5kvm ADHESION G-PROTEIN
COUPLED RECEPTOR G1
(Mus
musculus) 		5 / 12 ALA A 235
LEU A 183
LEU A 212
LEU A 298
PHE A 293
 None
 1.08A 3fl9G-5kvmA:
undetectable		 3fl9G-5kvmA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5kvm ADHESION G-PROTEIN
COUPLED RECEPTOR G1
(Mus
musculus) 		3 / 3 SER A 294
ASP A 292
ASP A 231
 None
 0.82A 3iv6A-5kvmA:
undetectable		 3iv6A-5kvmA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 5kvm ADHESION G-PROTEIN
COUPLED RECEPTOR G1
(Mus
musculus) 		5 / 12 LEU A 298
GLY A 314
LEU A 289
GLU A 213
LEU A 212
 None
 1.31A 5emlA-5kvmA:
undetectable		 5emlA-5kvmA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 5kvm ADHESION G-PROTEIN
COUPLED RECEPTOR G1
(Mus
musculus) 		4 / 8 SER A  95
THR A  98
ARG A  29
PRO A  28
 None
 1.02A 5jhdE-5kvmA:
undetectable
5jhdG-5kvmA:
undetectable		 5jhdE-5kvmA:
23.33
5jhdG-5kvmA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OJ0_A_9WTA801_0
(PENICILLIN-BINDING
PROTEIN 2X)		 5kvm ADHESION G-PROTEIN
COUPLED RECEPTOR G1
(Mus
musculus) 		5 / 12 SER A 357
GLN A 208
SER A 360
GLY A 359
GLN A 210
 None
None
None
GOL  A 907 (-3.7A)
None
 1.31A 5oj0A-5kvmA:
undetectable		 5oj0A-5kvmA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 5kvm ADHESION G-PROTEIN
COUPLED RECEPTOR G1
(Mus
musculus) 		3 / 3 SER A 214
LYS A 215
SER A 218
 None
 0.75A 6az3P-5kvmA:
undetectable		 6az3P-5kvmA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 5kvm ADHESION G-PROTEIN
COUPLED RECEPTOR G1
(Mus
musculus) 		5 / 10 VAL A 273
ALA A 272
LEU A 269
LEU A 268
LEU A 382
 None
 1.02A 6f6nA-5kvmA:
undetectable
6f6nB-5kvmA:
undetectable		 6f6nA-5kvmA:
11.97
6f6nB-5kvmA:
11.63