SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kvp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5kvp ZOOCIN A
ENDOPEPTIDASE
(Streptococcus
equi) 		4 / 7 TYR A  87
THR A  85
VAL A 101
GLY A  53
 None
 0.88A 2a1mA-5kvpA:
undetectable		 2a1mA-5kvpA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5kvp ZOOCIN A
ENDOPEPTIDASE
(Streptococcus
equi) 		4 / 8 TYR A  87
THR A  85
VAL A 101
GLY A  53
 None
 0.84A 2a1oA-5kvpA:
undetectable		 2a1oA-5kvpA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 5kvp ZOOCIN A
ENDOPEPTIDASE
(Streptococcus
equi) 		4 / 5 HIS A 120
HIS A  89
ASP A  38
HIS A 122
 None
UNL  A 202 ( 3.8A)
ZN  A 201 (-1.9A)
ZN  A 201 (-3.1A)
 1.15A 3c0zA-5kvpA:
undetectable		 3c0zA-5kvpA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 5kvp ZOOCIN A
ENDOPEPTIDASE
(Streptococcus
equi) 		4 / 6 HIS A 120
HIS A  89
ASP A  38
HIS A 122
 None
UNL  A 202 ( 3.8A)
ZN  A 201 (-1.9A)
ZN  A 201 (-3.1A)
 1.17A 3c0zC-5kvpA:
undetectable		 3c0zC-5kvpA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5kvp ZOOCIN A
ENDOPEPTIDASE
(Streptococcus
equi) 		4 / 7 ILE A  93
PHE A  57
HIS A 120
VAL A  35
 None
 1.08A 4a97D-5kvpA:
undetectable		 4a97D-5kvpA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5kvp ZOOCIN A
ENDOPEPTIDASE
(Streptococcus
equi) 		4 / 6 ILE A  93
PHE A  57
HIS A 120
VAL A  35
 None
 1.14A 4a97I-5kvpA:
undetectable		 4a97I-5kvpA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5kvp ZOOCIN A
ENDOPEPTIDASE
(Streptococcus
equi) 		4 / 8 VAL A  75
ALA A  74
GLY A  72
GLY A 111
 None
 0.83A 5e26C-5kvpA:
undetectable
5e26D-5kvpA:
undetectable		 5e26C-5kvpA:
16.19
5e26D-5kvpA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 5kvp ZOOCIN A
ENDOPEPTIDASE
(Streptococcus
equi) 		5 / 12 GLY A 108
VAL A 101
SER A  91
LEU A  90
VAL A  47
 None
 1.29A 5ubbA-5kvpA:
undetectable		 5ubbA-5kvpA:
20.43