SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kvr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_A_T44A128_1
(TRANSTHYRETIN)		 5kvr PYRUVATE
DEHYDROGENASE
COMPLEX REPRESSOR
(Escherichia
coli) 		4 / 4 LYS A  61
LEU A  58
ALA A  60
LEU A  64
 None
 1.26A 2roxA-5kvrA:
undetectable		 2roxA-5kvrA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 5kvr PYRUVATE
DEHYDROGENASE
COMPLEX REPRESSOR
(Escherichia
coli) 		4 / 6 LEU A  63
GLN A  17
LEU A  19
GLU A  20
 None
 1.04A 3h5gB-5kvrA:
undetectable
3h5gC-5kvrA:
undetectable		 3h5gB-5kvrA:
19.44
3h5gC-5kvrA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_ACTA405_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5kvr PYRUVATE
DEHYDROGENASE
COMPLEX REPRESSOR
(Escherichia
coli) 		4 / 6 THR A  72
ARG A  66
PRO A  35
ILE A  55
 None
 1.47A 6ef6A-5kvrA:
undetectable		 6ef6A-5kvrA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_ACTA405_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5kvr PYRUVATE
DEHYDROGENASE
COMPLEX REPRESSOR
(Escherichia
coli) 		4 / 6 THR A  72
ARG A  66
PRO A  36
ILE A  55
 None
 1.16A 6ef6A-5kvrA:
undetectable		 6ef6A-5kvrA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		 5kvr PYRUVATE
DEHYDROGENASE
COMPLEX REPRESSOR
(Escherichia
coli) 		4 / 4 LYS A  61
LEU A  58
ALA A  60
LEU A  64
 None
 1.32A 6gnrA-5kvrA:
undetectable		 6gnrA-5kvrA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 5kvr PYRUVATE
DEHYDROGENASE
COMPLEX REPRESSOR
(Escherichia
coli) 		4 / 4 LYS A  61
LEU A  58
ALA A  60
LEU A  64
 None
 1.34A 6gnrB-5kvrA:
undetectable		 6gnrB-5kvrA:
21.54