SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kvu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 12 PHE A  24
ALA A 615
ALA A 612
LEU A  12
GLY A 616
None
1.17A 1qabF-5kvuA:
undetectable
1qabF-5kvuA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
4 / 7 THR A 173
THR A 375
SER A 253
VAL A 349
None
1.18A 1tv8A-5kvuA:
undetectable
1tv8A-5kvuA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_B_SAMB2501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
4 / 7 THR A 173
THR A 375
SER A 253
VAL A 349
None
1.15A 1tv8B-5kvuA:
undetectable
1tv8B-5kvuA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 11 GLU A 155
ALA A 152
ILE A 640
ASP A 637
PRO A 150
None
1.23A 2admA-5kvuA:
undetectable
2admA-5kvuA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 11 GLU A 155
ALA A 152
ILE A 640
ASP A 637
PRO A 150
None
1.16A 2admB-5kvuA:
undetectable
2admB-5kvuA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
4 / 8 THR A 173
THR A 375
SER A 253
VAL A 349
None
1.18A 2fb2A-5kvuA:
undetectable
2fb2A-5kvuA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
4 / 7 THR A 173
THR A 375
SER A 253
VAL A 349
None
1.12A 2fb2B-5kvuA:
undetectable
2fb2B-5kvuA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 12 LEU A 705
ASP A 658
LEU A 657
SER A 649
LEU A 643
None
1.26A 2oipB-5kvuA:
undetectable
2oipB-5kvuA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
4 / 5 GLU A 430
PRO A 432
ILE A 431
GLY A 456
None
1.11A 2qeuA-5kvuA:
undetectable
2qeuC-5kvuA:
undetectable
2qeuA-5kvuA:
12.50
2qeuC-5kvuA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
4 / 8 ILE A 359
PHE A 401
LEU A 560
PHE A 557
None
0.96A 2vdbA-5kvuA:
undetectable
2vdbA-5kvuA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 12 ALA A 377
THR A 375
VAL A 250
GLY A 249
PRO A 329
None
1.23A 2ve3B-5kvuA:
undetectable
2ve3B-5kvuA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 12 ILE A  44
THR A  13
ASN A  81
VAL A 136
ILE A   8
None
1.17A 2vn0A-5kvuA:
undetectable
2vn0A-5kvuA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YDO_A_ADNA400_1
(ADENOSINE RECEPTOR
A2A)
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 12 LEU A 643
PHE A 610
GLU A 609
ASN A 659
ILE A  27
None
1.26A 2ydoA-5kvuA:
2.2
2ydoA-5kvuA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 12 ARG A 731
LEU A 694
GLY A 661
ASN A 659
VAL A 708
None
1.13A 2zznA-5kvuA:
undetectable
2zznA-5kvuA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 12 GLY A 587
GLY A 586
LEU A  85
THR A 583
GLU A 582
NAP  A 801 (-3.0A)
NAP  A 801 (-3.8A)
None
None
None
1.19A 3ckkA-5kvuA:
undetectable
3ckkA-5kvuA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
3 / 3 ASN A 393
ASN A 398
GLU A 533
None
None
EDO  A 803 (-4.0A)
0.84A 3kpdC-5kvuA:
undetectable
3kpdC-5kvuA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
3 / 3 ASN A 393
ASN A 398
GLU A 533
None
None
EDO  A 803 (-4.0A)
0.86A 3kpdB-5kvuA:
undetectable
3kpdB-5kvuA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 12 ARG A 147
TRP A 604
GLY A 584
ALA A 585
SER A 565
MLT  A 802 ( 4.6A)
NAP  A 801 (-3.2A)
None
None
None
1.24A 3n8xA-5kvuA:
1.6
3n8xA-5kvuA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
4 / 5 ASN A 137
GLU A 498
THR A 383
SER A 134
NAP  A 801 ( 3.6A)
None
None
MLT  A 802 (-2.6A)
1.40A 3p2kC-5kvuA:
undetectable
3p2kC-5kvuA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 ASN A 342
PHE A 343
GLY A 270
TYR A 238
PHE A 252
None
1.13A 3r6wA-5kvuA:
undetectable
3r6wB-5kvuA:
1.5
3r6wA-5kvuA:
15.84
3r6wB-5kvuA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
4 / 7 VAL A 216
LEU A 192
MET A 190
ILE A 224
None
1.00A 3rfmA-5kvuA:
undetectable
3rfmA-5kvuA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 9 GLY A 292
LEU A 309
ASP A 301
ASN A 294
ILE A 306
None
1.15A 3wdmC-5kvuA:
undetectable
3wdmC-5kvuA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
4 / 7 GLU A 187
TYR A 184
GLU A 381
ARG A 495
None
1.09A 4mi4B-5kvuA:
undetectable
4mi4C-5kvuA:
undetectable
4mi4B-5kvuA:
11.99
4mi4C-5kvuA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
4 / 8 GLU A 187
TYR A 184
GLU A 381
ARG A 495
None
1.11A 4mj8B-5kvuA:
undetectable
4mj8C-5kvuA:
undetectable
4mj8B-5kvuA:
12.15
4mj8C-5kvuA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 12 ASP A 647
ALA A 152
TYR A 156
VAL A 153
GLY A 641
None
1.30A 4mm4B-5kvuA:
undetectable
4mm4B-5kvuA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
4 / 6 LEU A 666
GLN A 672
LEU A 694
GLU A 698
None
1.11A 4nc3A-5kvuA:
5.5
4nc3A-5kvuA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 11 SER A  89
ALA A 589
PRO A 590
THR A  13
ILE A  44
MLT  A 802 ( 3.0A)
NAP  A 801 (-4.0A)
NAP  A 801 (-4.6A)
None
None
1.28A 4uuuB-5kvuA:
undetectable
4uuuB-5kvuA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 12 GLU A 609
GLY A 608
LEU A 569
SER A 570
VAL A 153
None
1.07A 5dpdA-5kvuA:
2.1
5dpdA-5kvuA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 12 ILE A  83
TYR A  10
GLY A 616
GLY A 614
LEU A 666
None
0.95A 5eqbA-5kvuA:
undetectable
5eqbA-5kvuA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 12 ALA A 738
ILE A  83
TYR A  10
GLY A 614
LEU A 666
None
1.16A 5eshA-5kvuA:
undetectable
5eshA-5kvuA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 12 ALA A 742
ILE A  83
TYR A  10
GLY A 614
LEU A 666
None
1.12A 5eshA-5kvuA:
undetectable
5eshA-5kvuA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
4 / 6 LYS A 154
ARG A 158
ASP A 540
GLY A 538
None
1.17A 5hp1A-5kvuA:
undetectable
5hp1A-5kvuA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 GLY A 413
GLY A 546
LEU A 414
GLU A 421
TYR A 422
None
None
None
None
MLT  A 802 (-4.0A)
1.33A 5hwkA-5kvuA:
undetectable
5hwkA-5kvuA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 10 GLY A 413
GLY A 546
LEU A 414
GLU A 421
TYR A 422
None
None
None
None
MLT  A 802 (-4.0A)
1.32A 5hwkB-5kvuA:
undetectable
5hwkB-5kvuA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
4 / 8 PHE A 394
ILE A 391
PHE A 401
PRO A 410
None
0.97A 5x23A-5kvuA:
undetectable
5x23A-5kvuA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 12 ILE A 701
ASP A 658
GLY A 661
PHE A 664
MET A 730
None
1.08A 5x5qB-5kvuA:
undetectable
5x5qB-5kvuA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 12 LEU A 553
MET A 522
THR A 408
GLY A 407
MET A 485
None
1.45A 6brdA-5kvuA:
undetectable
6brdA-5kvuA:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D6T_D_FYPD406_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
HUMAN GABA-A
RECEPTOR SUBUNIT
GAMMA-2)
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
5 / 11 TYR A  10
THR A 583
PHE A  24
ALA A  20
THR A  21
None
1.32A 6d6tD-5kvuA:
2.0
6d6tE-5kvuA:
0.0
6d6tD-5kvuA:
19.89
6d6tE-5kvuA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_ACTA405_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
4 / 6 THR A 259
PRO A 346
GLN A  94
ILE A 350
None
None
NAP  A 801 ( 4.3A)
NAP  A 801 (-3.6A)
1.30A 6ef6A-5kvuA:
undetectable
6ef6A-5kvuA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
4 / 5 VAL A 295
PHE A 228
MET A 229
GLY A 181
None
1.43A 6hd4A-5kvuA:
undetectable
6hd4A-5kvuA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis)
4 / 8 VAL A 295
ASN A 296
PRO A 266
ILE A 267
None
1.04A 6hzpA-5kvuA:
undetectable
6hzpA-5kvuA:
21.66