SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kwa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5kwa PROTEASOME-ASSOCIATE
D ATPASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 396
LEU A 426
LEU A 431
GLY A 288
PHE A 353
 None
 1.39A 1d4fD-5kwaA:
undetectable		 1d4fD-5kwaA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 5kwa PROTEASOME-ASSOCIATE
D ATPASE
(Mycobacterium
tuberculosis) 		4 / 8 TYR A 487
SER A 550
ILE A 551
LEU A 547
 None
 0.83A 1eupA-5kwaA:
undetectable		 1eupA-5kwaA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_B_BEZB1162_0
(PEROXIREDOXIN 5)		 5kwa PROTEASOME-ASSOCIATE
D ATPASE
(Mycobacterium
tuberculosis) 		4 / 8 PRO A 440
PRO A 295
GLY A 296
CYH A 297
 None
ADP  A 701 (-4.9A)
ADP  A 701 (-3.3A)
None
 0.87A 1h4oB-5kwaA:
undetectable		 1h4oB-5kwaA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_G_BEZG1162_0
(PEROXIREDOXIN 5)		 5kwa PROTEASOME-ASSOCIATE
D ATPASE
(Mycobacterium
tuberculosis) 		4 / 8 PRO A 440
PRO A 295
GLY A 296
CYH A 297
 None
ADP  A 701 (-4.9A)
ADP  A 701 (-3.3A)
None
 0.83A 1h4oG-5kwaA:
undetectable		 1h4oG-5kwaA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OC3_A_BEZA201_0
(PEROXIREDOXIN 5)		 5kwa PROTEASOME-ASSOCIATE
D ATPASE
(Mycobacterium
tuberculosis) 		4 / 8 PRO A 440
PRO A 295
GLY A 296
CYH A 297
 None
ADP  A 701 (-4.9A)
ADP  A 701 (-3.3A)
None
 0.88A 1oc3A-5kwaA:
undetectable		 1oc3A-5kwaA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5kwa PROTEASOME-ASSOCIATE
D ATPASE
(Mycobacterium
tuberculosis) 		4 / 7 PHE A 369
ALA A 414
ILE A 302
ILE A 435
 None
 0.95A 1oniD-5kwaA:
undetectable
1oniF-5kwaA:
undetectable		 1oniD-5kwaA:
17.61
1oniF-5kwaA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5kwa PROTEASOME-ASSOCIATE
D ATPASE
(Mycobacterium
tuberculosis) 		3 / 3 LYS A 299
ASP A 419
ASN A 416
 ADP  A 701 (-3.0A)
None
ADP  A 701 ( 4.4A)
 1.02A 2bm9A-5kwaA:
3.3		 2bm9A-5kwaA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_1
(HIV-1 PROTEASE)		 5kwa PROTEASOME-ASSOCIATE
D ATPASE
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 492
VAL A 552
ILE A 544
VAL A 522
ILE A 551
 None
 1.06A 3d20A-5kwaA:
undetectable		 3d20A-5kwaA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5kwa PROTEASOME-ASSOCIATE
D ATPASE
(Mycobacterium
tuberculosis) 		4 / 5 PHE A 377
LEU A 290
GLY A 413
ILE A 376
 None
 0.87A 3wrkA-5kwaA:
undetectable		 3wrkA-5kwaA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_C_MIYC392_1
(TETX2 PROTEIN)		 5kwa PROTEASOME-ASSOCIATE
D ATPASE
(Mycobacterium
tuberculosis) 		5 / 12 GLU A 262
VAL A 289
ILE A 435
GLN A 263
GLU A 269
 None
 1.41A 4a99A-5kwaA:
undetectable
4a99C-5kwaA:
undetectable		 4a99A-5kwaA:
22.05
4a99C-5kwaA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_1
(ASPARTYL PROTEASE)		 5kwa PROTEASOME-ASSOCIATE
D ATPASE
(Mycobacterium
tuberculosis) 		5 / 10 ASP A 492
VAL A 552
ILE A 544
VAL A 522
ILE A 551
 None
 1.11A 4dqcA-5kwaA:
undetectable		 4dqcA-5kwaA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5kwa PROTEASOME-ASSOCIATE
D ATPASE
(Mycobacterium
tuberculosis) 		4 / 4 LEU A 290
ILE A 435
GLY A 413
ILE A 264
 None
 0.88A 5dzk3-5kwaA:
undetectable
5dzkm-5kwaA:
3.0		 5dzk3-5kwaA:
14.29
5dzkm-5kwaA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5kwa PROTEASOME-ASSOCIATE
D ATPASE
(Mycobacterium
tuberculosis) 		4 / 5 ILE A 435
GLY A 413
ILE A 264
LEU A 290
 None
 0.82A 5dzkB-5kwaA:
3.1
5dzkI-5kwaA:
3.0
5dzkW-5kwaA:
undetectable		 5dzkB-5kwaA:
19.62
5dzkI-5kwaA:
19.05
5dzkW-5kwaA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5kwa PROTEASOME-ASSOCIATE
D ATPASE
(Mycobacterium
tuberculosis) 		4 / 5 ILE A 435
GLY A 413
ILE A 264
LEU A 290
 None
 0.80A 5dzki-5kwaA:
3.0
5dzkj-5kwaA:
3.0
5dzkx-5kwaA:
undetectable		 5dzki-5kwaA:
19.05
5dzkj-5kwaA:
19.05
5dzkx-5kwaA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5kwa PROTEASOME-ASSOCIATE
D ATPASE
(Mycobacterium
tuberculosis) 		4 / 4 ILE A 435
GLY A 413
ILE A 264
LEU A 290
 None
 0.90A 5dzkl-5kwaA:
2.9
5dzkz-5kwaA:
undetectable		 5dzkl-5kwaA:
19.05
5dzkz-5kwaA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 5kwa PROTEASOME-ASSOCIATE
D ATPASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 222
ASP A 223
GLU A 160
LEU A 175
SER A 162
 None
 1.40A 5hnxB-5kwaA:
undetectable		 5hnxB-5kwaA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 5kwa PROTEASOME-ASSOCIATE
D ATPASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 519
GLY A 516
ALA A 445
TYR A 487
VAL A 483
 None
ADP  A 701 (-3.4A)
None
None
None
 1.20A 5hw4A-5kwaA:
2.3		 5hw4A-5kwaA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5kwa PROTEASOME-ASSOCIATE
D ATPASE
(Mycobacterium
tuberculosis) 		4 / 5 PHE A 353
LEU A 431
GLY A 413
ILE A 352
 None
 0.97A 5ik1A-5kwaA:
undetectable		 5ik1A-5kwaA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5kwa PROTEASOME-ASSOCIATE
D ATPASE
(Mycobacterium
tuberculosis) 		4 / 5 PHE A 377
LEU A 290
GLY A 413
ILE A 376
 None
 0.96A 5ik1A-5kwaA:
undetectable		 5ik1A-5kwaA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGY_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5kwa PROTEASOME-ASSOCIATE
D ATPASE
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 289
VAL A 433
GLN A 263
 None
 0.65A 5qgyA-5kwaA:
undetectable		 5qgyA-5kwaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGZ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5kwa PROTEASOME-ASSOCIATE
D ATPASE
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 289
VAL A 433
GLN A 263
 None
 0.65A 5qgzA-5kwaA:
undetectable		 5qgzA-5kwaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH0_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5kwa PROTEASOME-ASSOCIATE
D ATPASE
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 289
VAL A 433
GLN A 263
 None
 0.66A 5qh0A-5kwaA:
undetectable		 5qh0A-5kwaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH2_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5kwa PROTEASOME-ASSOCIATE
D ATPASE
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 289
VAL A 433
GLN A 263
 None
 0.63A 5qh2A-5kwaA:
undetectable		 5qh2A-5kwaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH3_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5kwa PROTEASOME-ASSOCIATE
D ATPASE
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 289
VAL A 433
GLN A 263
 None
 0.65A 5qh3A-5kwaA:
undetectable		 5qh3A-5kwaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH6_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5kwa PROTEASOME-ASSOCIATE
D ATPASE
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 289
VAL A 433
GLN A 263
 None
 0.66A 5qh6A-5kwaA:
undetectable		 5qh6A-5kwaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHA_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5kwa PROTEASOME-ASSOCIATE
D ATPASE
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 289
VAL A 433
GLN A 263
 None
 0.66A 5qhaA-5kwaA:
undetectable		 5qhaA-5kwaA:
22.22