SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kwd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 5kwd ANKYRIN
REPEAT-CONTAINING
PROTEIN
(Metallosphaera
yellowstonensis) 		3 / 3 ARG A  70
SER A 100
TYR A 108
 None
 1.00A 2q2hA-5kwdA:
undetectable
2q2hB-5kwdA:
undetectable		 2q2hA-5kwdA:
21.52
2q2hB-5kwdA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 5kwd ANKYRIN
REPEAT-CONTAINING
PROTEIN
(Metallosphaera
yellowstonensis) 		5 / 8 ASP A 101
ASP A  99
GLY A  69
TYR A  75
ARG A  37
 None
 1.39A 3s3nA-5kwdA:
undetectable		 3s3nA-5kwdA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 5kwd ANKYRIN
REPEAT-CONTAINING
PROTEIN
(Metallosphaera
yellowstonensis) 		5 / 12 VAL A  19
LEU A   7
LEU A  40
ILE A  51
ALA A  60
 None
 0.99A 4p65B-5kwdA:
undetectable
4p65D-5kwdA:
undetectable
4p65I-5kwdA:
undetectable
4p65J-5kwdA:
undetectable		 4p65B-5kwdA:
11.81
4p65D-5kwdA:
11.81
4p65I-5kwdA:
7.64
4p65J-5kwdA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 5kwd ANKYRIN
REPEAT-CONTAINING
PROTEIN
(Metallosphaera
yellowstonensis) 		5 / 12 VAL A  85
LEU A  73
LEU A 106
ILE A 117
ALA A 126
 None
 1.00A 4p65B-5kwdA:
undetectable
4p65D-5kwdA:
undetectable
4p65I-5kwdA:
undetectable
4p65J-5kwdA:
undetectable		 4p65B-5kwdA:
11.81
4p65D-5kwdA:
11.81
4p65I-5kwdA:
7.64
4p65J-5kwdA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 5kwd ANKYRIN
REPEAT-CONTAINING
PROTEIN
(Metallosphaera
yellowstonensis) 		5 / 12 LEU A 106
VAL A  85
LEU A  73
ILE A 117
ALA A 126
 None
 1.02A 4p65F-5kwdA:
undetectable
4p65H-5kwdA:
undetectable
4p65K-5kwdA:
undetectable
4p65L-5kwdA:
undetectable		 4p65F-5kwdA:
11.81
4p65H-5kwdA:
11.81
4p65K-5kwdA:
7.64
4p65L-5kwdA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5kwd ANKYRIN
REPEAT-CONTAINING
PROTEIN
(Metallosphaera
yellowstonensis) 		4 / 4 ASP A  68
SER A  67
ASP A  66
HIS A  41
 None
 1.31A 5wyqB-5kwdA:
undetectable		 5wyqB-5kwdA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5kwd ANKYRIN
REPEAT-CONTAINING
PROTEIN
(Metallosphaera
yellowstonensis) 		4 / 4 ASP A 101
SER A 100
ASP A  99
HIS A  74
 None
 1.32A 5wyqB-5kwdA:
undetectable		 5wyqB-5kwdA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5kwd ANKYRIN
REPEAT-CONTAINING
PROTEIN
(Metallosphaera
yellowstonensis) 		4 / 4 ASP A 134
SER A 133
ASP A 132
HIS A 107
 None
 1.36A 5wyqB-5kwdA:
undetectable		 5wyqB-5kwdA:
23.62