SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kwl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 5kwl VP3
(Enterovirus
C) 		5 / 12 ALA 3 216
ILE 3  53
ARG 3  94
LEU 3  85
PHE 3 116
 None
 1.05A 2qk8A-5kwl3:
undetectable		 2qk8A-5kwl3:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5kwl VP3
(Enterovirus
C) 		5 / 12 ALA 3 216
ILE 3  53
ARG 3  94
LEU 3  85
PHE 3 116
 None
 1.12A 3datA-5kwl3:
undetectable		 3datA-5kwl3:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 5kwl VP3
(Enterovirus
C) 		4 / 6 GLY 3 138
GLU 3 186
ASP 3  92
ASP 3 140
 None
 1.00A 3vywC-5kwl3:
undetectable		 3vywC-5kwl3:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5kwl VP3
(Enterovirus
C) 		4 / 7 ILE 3  82
HIS 3 153
VAL 3 168
PHE 3 118
 None
 1.08A 4a97H-5kwl3:
undetectable		 4a97H-5kwl3:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 5kwl VP3
(Enterovirus
C) 		4 / 7 SER 3  86
SER 3  91
PHE 3 184
GLU 3 186
 None
 1.38A 4xzkA-5kwl3:
undetectable		 4xzkA-5kwl3:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5kwl VP3
(Enterovirus
C) 		4 / 5 MET 3 166
TYR 3 189
GLY 3 188
GLY 3 187
 None
 1.19A 5x7pA-5kwl3:
undetectable		 5x7pA-5kwl3:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 5kwl VP3
(Enterovirus
C) 		5 / 12 ILE 3 190
PHE 3 118
LEU 3 211
LEU 3  57
LEU 3  85
 None
 1.25A 5xxiA-5kwl3:
undetectable		 5xxiA-5kwl3:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA824_0
(GEPHYRIN)		 5kwl VP3
(Enterovirus
C) 		4 / 4 LEU 3  57
ASP 3  92
PRO 3  93
ARG 3  94
 None
 1.39A 6fgdA-5kwl3:
undetectable		 6fgdA-5kwl3:
23.62