SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kwn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 5kwn E3 UBIQUITIN-PROTEIN
LIGASE COP1
(Arabidopsis
thaliana) 		4 / 5 VAL A 523
GLY A 524
VAL A 511
TRP A 467
 None
 0.93A 1tkqB-5kwnA:
undetectable		 1tkqB-5kwnA:
5.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 5kwn E3 UBIQUITIN-PROTEIN
LIGASE COP1
(Arabidopsis
thaliana) 		5 / 12 ILE A 530
GLY A 524
GLY A 482
VAL A 552
ALA A 551
 None
 0.88A 1vptA-5kwnA:
undetectable		 1vptA-5kwnA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 5kwn E3 UBIQUITIN-PROTEIN
LIGASE COP1
(Arabidopsis
thaliana) 		3 / 3 PRO A 624
GLY A 588
TYR A 615
 None
 0.70A 2vouB-5kwnA:
undetectable		 2vouB-5kwnA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 5kwn E3 UBIQUITIN-PROTEIN
LIGASE COP1
(Arabidopsis
thaliana) 		3 / 3 PRO A 624
GLY A 588
TYR A 615
 None
 0.71A 2vouC-5kwnA:
undetectable		 2vouC-5kwnA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 5kwn E3 UBIQUITIN-PROTEIN
LIGASE COP1
(Arabidopsis
thaliana) 		3 / 3 ILE A 373
SER A 424
SER A 376
 None
 0.62A 3iltH-5kwnA:
undetectable		 3iltH-5kwnA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 5kwn E3 UBIQUITIN-PROTEIN
LIGASE COP1
(Arabidopsis
thaliana) 		3 / 3 ILE A 395
SER A 376
SER A 424
 None
 0.59A 3iltH-5kwnA:
undetectable		 3iltH-5kwnA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 5kwn E3 UBIQUITIN-PROTEIN
LIGASE COP1
(Arabidopsis
thaliana) 		4 / 5 SER A 376
VAL A 374
GLY A 390
ALA A 389
 None
 1.06A 5k50A-5kwnA:
undetectable		 5k50A-5kwnA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 5kwn E3 UBIQUITIN-PROTEIN
LIGASE COP1
(Arabidopsis
thaliana) 		4 / 6 PHE A 400
PHE A 398
ILE A 377
THR A 388
 None
 1.08A 5vceA-5kwnA:
undetectable		 5vceA-5kwnA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5kwn E3 UBIQUITIN-PROTEIN
LIGASE COP1
(Arabidopsis
thaliana) 		4 / 7 ASP A 569
THR A 568
TRP A 467
LEU A 572
 None
 1.20A 5x1bA-5kwnA:
undetectable
5x1bC-5kwnA:
undetectable
5x1bP-5kwnA:
undetectable		 5x1bA-5kwnA:
20.48
5x1bC-5kwnA:
20.18
5x1bP-5kwnA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5kwn E3 UBIQUITIN-PROTEIN
LIGASE COP1
(Arabidopsis
thaliana) 		4 / 7 ASP A 569
THR A 568
TRP A 467
LEU A 572
 None
 1.19A 5x1fA-5kwnA:
undetectable
5x1fC-5kwnA:
undetectable
5x1fP-5kwnA:
undetectable		 5x1fA-5kwnA:
20.48
5x1fC-5kwnA:
20.18
5x1fP-5kwnA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5kwn E3 UBIQUITIN-PROTEIN
LIGASE COP1
(Arabidopsis
thaliana) 		4 / 7 ASP A 569
THR A 568
TRP A 467
LEU A 572
 None
 1.21A 6nmfA-5kwnA:
undetectable
6nmfC-5kwnA:
undetectable
6nmfP-5kwnA:
undetectable		 6nmfA-5kwnA:
20.48
6nmfC-5kwnA:
20.18
6nmfP-5kwnA:
20.18