SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kwr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 5kwr CEREBELLIN-1
(Rattus
norvegicus) 		4 / 7 THR A 103
ASN A 134
LEU A 133
PHE A 185
 None
 1.37A 4awuA-5kwrA:
undetectable		 4awuA-5kwrA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 5kwr CEREBELLIN-1
(Rattus
norvegicus) 		4 / 8 SER A 186
PHE A 185
THR A 103
PHE A 188
 None
 1.03A 4drjB-5kwrA:
undetectable		 4drjB-5kwrA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 5kwr CEREBELLIN-1
(Rattus
norvegicus) 		4 / 6 PHE A 114
ALA A 167
ALA A 106
PRO A 107
 None
 1.01A 4dtzB-5kwrA:
undetectable		 4dtzB-5kwrA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 5kwr CEREBELLIN-1
(Rattus
norvegicus) 		4 / 7 ASN A 123
GLY A 179
ILE A  84
LEU A 171
 None
 0.78A 4ejjD-5kwrA:
undetectable		 4ejjD-5kwrA:
17.75