SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kws'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5kws GALACTOSE-BINDING
PROTEIN
(Yersinia
pestis) 		4 / 6 TYR A  12
ILE A   5
ASN A  39
LEU A  55
 None
None
GOL  A 403 (-2.9A)
None
 1.27A 2wekB-5kwsA:
2.5		 2wekB-5kwsA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5kws GALACTOSE-BINDING
PROTEIN
(Yersinia
pestis) 		5 / 11 ASP A 267
ASN A 271
LEU A 268
VAL A  88
ALA A  64
 None
GOL  A 405 (-3.6A)
None
None
None
 1.39A 3n23C-5kwsA:
3.0		 3n23C-5kwsA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5kws GALACTOSE-BINDING
PROTEIN
(Yersinia
pestis) 		5 / 12 GLY A 281
ILE A   5
LYS A 276
ALA A 274
ALA A 273
 None
None
EDO  A 406 ( 2.7A)
GOL  A 405 (-3.5A)
None
 1.08A 3sueA-5kwsA:
undetectable		 3sueA-5kwsA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5kws GALACTOSE-BINDING
PROTEIN
(Yersinia
pestis) 		5 / 12 LYS A 125
GLY A 297
ALA A 237
ASP A 299
VAL A 298
 None
 1.41A 4df3A-5kwsA:
3.7		 4df3A-5kwsA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5kws GALACTOSE-BINDING
PROTEIN
(Yersinia
pestis) 		5 / 12 LYS A 125
GLY A 297
ALA A 237
ASP A 299
VAL A 298
 None
 1.43A 4df3B-5kwsA:
undetectable		 4df3B-5kwsA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5kws GALACTOSE-BINDING
PROTEIN
(Yersinia
pestis) 		3 / 3 ASN A  91
ASP A  14
ASP A 212
 BGC  A 401 (-3.0A)
BGC  A 401 (-2.9A)
None
 0.75A 4obwD-5kwsA:
undetectable		 4obwD-5kwsA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)		 5kws GALACTOSE-BINDING
PROTEIN
(Yersinia
pestis) 		3 / 3 GLY A 198
PRO A 199
GLN A 177
 None
 0.52A 4oltB-5kwsA:
undetectable		 4oltB-5kwsA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 5kws GALACTOSE-BINDING
PROTEIN
(Yersinia
pestis) 		5 / 12 LEU A 145
GLY A 234
PHE A 143
ALA A 241
ALA A 215
 None
 1.43A 4pclB-5kwsA:
4.6		 4pclB-5kwsA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)		 5kws GALACTOSE-BINDING
PROTEIN
(Yersinia
pestis) 		3 / 3 GLY A 198
PRO A 199
GLN A 177
 None
 0.55A 4qwpB-5kwsA:
undetectable		 4qwpB-5kwsA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 5kws GALACTOSE-BINDING
PROTEIN
(Yersinia
pestis) 		5 / 12 ALA A 129
GLN A 128
LYS A 169
THR A 165
VAL A 117
 None
 1.39A 4qzuA-5kwsA:
undetectable		 4qzuA-5kwsA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 5kws GALACTOSE-BINDING
PROTEIN
(Yersinia
pestis) 		5 / 11 LEU A 255
ALA A 237
VAL A 235
ASP A 154
ASP A  14
 None
None
None
BGC  A 401 (-3.5A)
BGC  A 401 (-2.9A)
 1.37A 4uuuA-5kwsA:
undetectable
4uuuB-5kwsA:
undetectable		 4uuuA-5kwsA:
19.65
4uuuB-5kwsA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5kws GALACTOSE-BINDING
PROTEIN
(Yersinia
pestis) 		5 / 12 THR A 159
GLU A 156
THR A 110
GLY A 148
HIS A 152
 None
None
None
None
BGC  A 401 (-3.9A)
 1.33A 5axdC-5kwsA:
3.9		 5axdC-5kwsA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA404_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 5kws GALACTOSE-BINDING
PROTEIN
(Yersinia
pestis) 		4 / 4 TYR A  90
ASN A  66
ILE A  65
GLN A  48
 None
 1.41A 5hhjA-5kwsA:
0.0		 5hhjA-5kwsA:
21.55