SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kwy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K8M_A_ACRA720_1 (ALPHA-AMYLASE, SUSG)	5kwy	EPIDIDYMAL SECRETORY PROTEIN E1 (Homo sapiens)	4 / 7	GLU C 127 TRP C 128 LEU C 113 ASN C 111	None None C3S C 203 ( 4.5A) None	1.14A	3k8mA-5kwyC: undetectable	3k8mA-5kwyC: 11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IFX_A_ACTA404_0 (THIAMINE BIOSYNTHESIS LIPOPROTEIN APBE)	5kwy	EPIDIDYMAL SECRETORY PROTEIN E1 (Homo sapiens)	4 / 5	SER C 63 LYS C 103 LEU C 138 ASP C 31	None	1.31A	4ifxA-5kwyC: undetectable	4ifxA-5kwyC: 16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IG1_A_ACTA504_0 (FAD:PROTEIN FMN TRANSFERASE)	5kwy	EPIDIDYMAL SECRETORY PROTEIN E1 (Homo sapiens)	4 / 5	SER C 63 LYS C 103 LEU C 138 ASP C 31	None	1.32A	4ig1A-5kwyC: undetectable	4ig1A-5kwyC: 16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XDT_A_ACTA406_0 (FAD:PROTEIN FMN TRANSFERASE)	5kwy	EPIDIDYMAL SECRETORY PROTEIN E1 (Homo sapiens)	4 / 5	SER C 63 LYS C 103 LEU C 138 ASP C 31	None	1.29A	4xdtA-5kwyC: undetectable	4xdtA-5kwyC: 16.47

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3K8M_A_ACRA720_1","ALPHA-AMYLASE, SUSG","5kwy","EPIDIDYMAL SECRETORY PROTEIN E1","Homo sapiens",4,"GLU C 127;TRP C 128;LEU C 113;ASN C 111","None;None;C3S C 203 ( 4.5A);None","1.14A","3k8mA-5kwyC:undetectable","3k8mA-5kwyC:11.42"],["4IFX_A_ACTA404_0","THIAMINE BIOSYNTHESIS LIPOPROTEIN APBE","5kwy","EPIDIDYMAL SECRETORY PROTEIN E1","Homo sapiens",4,"SER C  63;LYS C 103;LEU C 138;ASP C  31","None","1.31A","4ifxA-5kwyC:undetectable","4ifxA-5kwyC:16.47"],["4IG1_A_ACTA504_0","FAD:PROTEIN FMN TRANSFERASE","5kwy","EPIDIDYMAL SECRETORY PROTEIN E1","Homo sapiens",4,"SER C  63;LYS C 103;LEU C 138;ASP C  31","None","1.32A","4ig1A-5kwyC:undetectable","4ig1A-5kwyC:16.47"],["4XDT_A_ACTA406_0","FAD:PROTEIN FMN TRANSFERASE","5kwy","EPIDIDYMAL SECRETORY PROTEIN E1","Homo sapiens",4,"SER C  63;LYS C 103;LEU C 138;ASP C  31","None","1.29A","4xdtA-5kwyC:undetectable","4xdtA-5kwyC:16.47"]]