SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kx6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5kx6 GALACTOSIDE
2-ALPHA-L-FUCOSYLTRA
NSFERASE
(Arabidopsis
thaliana) 		5 / 9 THR A 416
GLY A 485
PHE A 484
LEU A 470
SER A 482
 GDP  A 601 (-4.1A)
None
GDP  A 601 (-3.9A)
None
None
 1.23A 1l5lA-5kx6A:
undetectable		 1l5lA-5kx6A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5kx6 GALACTOSIDE
2-ALPHA-L-FUCOSYLTRA
NSFERASE
(Arabidopsis
thaliana) 		5 / 9 THR A 416
GLY A 485
PHE A 484
LEU A 470
SER A 482
 GDP  A 601 (-4.1A)
None
GDP  A 601 (-3.9A)
None
None
 1.23A 1l5mA-5kx6A:
undetectable		 1l5mA-5kx6A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_A_STRA301_1
(MINERALOCORTICOID
RECEPTOR)		 5kx6 GALACTOSIDE
2-ALPHA-L-FUCOSYLTRA
NSFERASE
(Arabidopsis
thaliana) 		5 / 12 ASN A 301
LEU A 269
SER A 306
LEU A 307
THR A 483
 None
 1.41A 2aa5A-5kx6A:
undetectable		 2aa5A-5kx6A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 5kx6 GALACTOSIDE
2-ALPHA-L-FUCOSYLTRA
NSFERASE
(Arabidopsis
thaliana) 		3 / 3 GLY A 312
GLU A 283
ASP A 315
 None
 0.60A 2b25B-5kx6A:
undetectable		 2b25B-5kx6A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 5kx6 GALACTOSIDE
2-ALPHA-L-FUCOSYLTRA
NSFERASE
(Arabidopsis
thaliana) 		4 / 5 ASP A  95
LEU A 101
GLY A 100
ARG A 333
 None
 1.09A 2j2pA-5kx6A:
undetectable
2j2pB-5kx6A:
undetectable		 2j2pA-5kx6A:
18.12
2j2pB-5kx6A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1291_1
(FICOLIN-2)		 5kx6 GALACTOSIDE
2-ALPHA-L-FUCOSYLTRA
NSFERASE
(Arabidopsis
thaliana) 		4 / 4 ASP A  95
LEU A 101
GLY A 100
ARG A 333
 None
 1.11A 2j2pD-5kx6A:
undetectable
2j2pE-5kx6A:
undetectable		 2j2pD-5kx6A:
18.12
2j2pE-5kx6A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 5kx6 GALACTOSIDE
2-ALPHA-L-FUCOSYLTRA
NSFERASE
(Arabidopsis
thaliana) 		4 / 5 PHE A 280
PHE A 281
PHE A 522
VAL A 297
 None
 1.09A 2lh6A-5kx6A:
undetectable		 2lh6A-5kx6A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5kx6 GALACTOSIDE
2-ALPHA-L-FUCOSYLTRA
NSFERASE
(Arabidopsis
thaliana) 		4 / 8 MET A 211
PHE A 215
ALA A 463
LEU A 464
 None
None
GDP  A 601 (-3.3A)
None
 1.05A 2o01A-5kx6A:
undetectable		 2o01A-5kx6A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 5kx6 GALACTOSIDE
2-ALPHA-L-FUCOSYLTRA
NSFERASE
(Arabidopsis
thaliana) 		5 / 12 SER A 191
LEU A 307
LEU A 317
PRO A 526
PRO A 525
 None
 1.23A 3dcjA-5kx6A:
undetectable
3dcjB-5kx6A:
3.4		 3dcjA-5kx6A:
18.42
3dcjB-5kx6A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 5kx6 GALACTOSIDE
2-ALPHA-L-FUCOSYLTRA
NSFERASE
(Arabidopsis
thaliana) 		3 / 3 GLU A 424
SER A 417
VAL A 365
 None
 0.84A 3eeoA-5kx6A:
undetectable		 3eeoA-5kx6A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5kx6 GALACTOSIDE
2-ALPHA-L-FUCOSYLTRA
NSFERASE
(Arabidopsis
thaliana) 		5 / 12 ASP A 550
GLU A 549
SER A 517
GLY A 554
LEU A 555
 None
 1.22A 3j6pB-5kx6A:
undetectable		 3j6pB-5kx6A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 5kx6 GALACTOSIDE
2-ALPHA-L-FUCOSYLTRA
NSFERASE
(Arabidopsis
thaliana) 		3 / 3 VAL A 346
VAL A 342
TRP A 343
 None
 0.88A 3l8lA-5kx6A:
undetectable
3l8lB-5kx6A:
undetectable		 3l8lA-5kx6A:
6.22
3l8lB-5kx6A:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5kx6 GALACTOSIDE
2-ALPHA-L-FUCOSYLTRA
NSFERASE
(Arabidopsis
thaliana) 		5 / 12 GLN A 448
TYR A 353
GLY A 421
ALA A 423
SER A 479
 None
 1.13A 3sudB-5kx6A:
undetectable		 3sudB-5kx6A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 5kx6 GALACTOSIDE
2-ALPHA-L-FUCOSYLTRA
NSFERASE
(Arabidopsis
thaliana) 		4 / 8 GLY A 344
TYR A 349
ALA A 465
GLU A 466
 None
None
None
GDP  A 601 (-3.2A)
 0.86A 3u9hA-5kx6A:
undetectable		 3u9hA-5kx6A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 5kx6 GALACTOSIDE
2-ALPHA-L-FUCOSYLTRA
NSFERASE
(Arabidopsis
thaliana) 		4 / 8 GLY A 344
TYR A 349
ALA A 465
GLU A 466
 None
None
None
GDP  A 601 (-3.2A)
 0.80A 3u9hB-5kx6A:
undetectable		 3u9hB-5kx6A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 5kx6 GALACTOSIDE
2-ALPHA-L-FUCOSYLTRA
NSFERASE
(Arabidopsis
thaliana) 		4 / 8 GLY A 344
TYR A 349
ALA A 465
GLU A 466
 None
None
None
GDP  A 601 (-3.2A)
 0.84A 4bjcA-5kx6A:
undetectable		 4bjcA-5kx6A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 5kx6 GALACTOSIDE
2-ALPHA-L-FUCOSYLTRA
NSFERASE
(Arabidopsis
thaliana) 		3 / 3 PRO A 393
VAL A 443
HIS A 444
 None
 0.85A 4pevC-5kx6A:
2.5		 4pevC-5kx6A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5kx6 GALACTOSIDE
2-ALPHA-L-FUCOSYLTRA
NSFERASE
(Arabidopsis
thaliana) 		4 / 6 GLU A 140
TYR A 334
LEU A 335
PHE A 219
 None
 1.33A 4twdF-5kx6A:
undetectable
4twdG-5kx6A:
undetectable		 4twdF-5kx6A:
19.18
4twdG-5kx6A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5kx6 GALACTOSIDE
2-ALPHA-L-FUCOSYLTRA
NSFERASE
(Arabidopsis
thaliana) 		4 / 6 GLU A 140
TYR A 334
LEU A 335
PHE A 219
 None
 1.21A 4twdI-5kx6A:
undetectable
4twdJ-5kx6A:
undetectable		 4twdI-5kx6A:
19.18
4twdJ-5kx6A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 5kx6 GALACTOSIDE
2-ALPHA-L-FUCOSYLTRA
NSFERASE
(Arabidopsis
thaliana) 		5 / 12 TYR A 195
PHE A 328
TYR A 302
TYR A 334
LEU A 335
 None
 1.35A 5czyA-5kx6A:
undetectable		 5czyA-5kx6A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 5kx6 GALACTOSIDE
2-ALPHA-L-FUCOSYLTRA
NSFERASE
(Arabidopsis
thaliana) 		5 / 9 LEU A 491
LEU A 331
GLY A 332
LEU A 187
ALA A 190
 None
 0.98A 5dqfA-5kx6A:
undetectable		 5dqfA-5kx6A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 5kx6 GALACTOSIDE
2-ALPHA-L-FUCOSYLTRA
NSFERASE
(Arabidopsis
thaliana) 		4 / 5 HIS A 523
ILE A 551
PHE A 368
ALA A 480
 None
None
GDP  A 601 (-4.9A)
None
 1.19A 5msdA-5kx6A:
undetectable		 5msdA-5kx6A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_1
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 5kx6 GALACTOSIDE
2-ALPHA-L-FUCOSYLTRA
NSFERASE
(Arabidopsis
thaliana) 		4 / 5 GLY A 284
ASP A 285
MET A 279
GLN A 254
 None
 1.33A 5ubbA-5kx6A:
undetectable		 5ubbA-5kx6A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5kx6 GALACTOSIDE
2-ALPHA-L-FUCOSYLTRA
NSFERASE
(Arabidopsis
thaliana) 		4 / 4 GLY A 461
ARG A 185
ASN A 460
LEU A 464
 None
None
GDP  A 601 ( 4.8A)
None
 1.16A 6b58A-5kx6A:
undetectable		 6b58A-5kx6A:
21.72