SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kxb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 5kxb WISTERIA FLORIBUNDA
AGGLUTININ
(Wisteria
floribunda) 		5 / 11 SER A 179
LEU A 137
GLY A 171
HIS A 253
GLU A 251
 MN  A 309 ( 4.1A)
None
None
None
None
 1.40A 1iolA-5kxbA:
undetectable		 1iolA-5kxbA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5kxb WISTERIA FLORIBUNDA
AGGLUTININ
(Wisteria
floribunda) 		4 / 7 PHE A 121
PHE A 156
LEU A 221
PHE A 103
 None
 1.00A 1wrlE-5kxbA:
undetectable		 1wrlE-5kxbA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 5kxb WISTERIA FLORIBUNDA
AGGLUTININ
(Wisteria
floribunda) 		5 / 12 ALA A 242
LEU A 139
LEU A 137
THR A 128
LEU A  81
 None
 1.00A 2nyuB-5kxbA:
undetectable		 2nyuB-5kxbA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 5kxb WISTERIA FLORIBUNDA
AGGLUTININ
(Wisteria
floribunda) 		5 / 12 PHE A  99
GLY A 238
ILE A  86
VAL A 235
ALA A 120
 None
 1.11A 4a6eA-5kxbA:
undetectable		 4a6eA-5kxbA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 5kxb WISTERIA FLORIBUNDA
AGGLUTININ
(Wisteria
floribunda) 		4 / 5 ALA A 153
ILE A 177
LEU A 137
ASN A 173
 None
 1.18A 4g19A-5kxbA:
undetectable		 4g19A-5kxbA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 5kxb WISTERIA FLORIBUNDA
AGGLUTININ
(Wisteria
floribunda) 		3 / 3 ARG A  40
ASP A 254
ASP A 190
 None
 0.78A 4kicB-5kxbA:
undetectable		 4kicB-5kxbA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_1
(ANDROGEN RECEPTOR)		 5kxb WISTERIA FLORIBUNDA
AGGLUTININ
(Wisteria
floribunda) 		5 / 12 LEU A  81
GLY A 238
VAL A 152
THR A 101
VAL A 195
 None
 1.38A 4okxA-5kxbA:
undetectable		 4okxA-5kxbA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8T_B_SAMB605_0
(GUANINE-N7
METHYLTRANSFERASE)		 5kxb WISTERIA FLORIBUNDA
AGGLUTININ
(Wisteria
floribunda) 		5 / 11 TRP A 163
GLY A 134
ASP A 117
ALA A 116
TYR A  74
 None
NGA  A 307 ( 3.8A)
NGA  A 307 (-2.7A)
NGA  A 307 ( 4.3A)
None
 1.46A 5c8tB-5kxbA:
undetectable		 5c8tB-5kxbA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OJ0_A_9WTA801_0
(PENICILLIN-BINDING
PROTEIN 2X)		 5kxb WISTERIA FLORIBUNDA
AGGLUTININ
(Wisteria
floribunda) 		5 / 12 ASN A 111
SER A 243
THR A  65
GLY A 118
THR A 158
 None
 1.33A 5oj0A-5kxbA:
undetectable		 5oj0A-5kxbA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5kxb WISTERIA FLORIBUNDA
AGGLUTININ
(Wisteria
floribunda) 		4 / 7 ILE A 230
LEU A 231
THR A 205
LEU A 206
 None
 1.01A 5xdqA-5kxbA:
undetectable
5xdqJ-5kxbA:
undetectable		 5xdqA-5kxbA:
17.34
5xdqJ-5kxbA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 5kxb WISTERIA FLORIBUNDA
AGGLUTININ
(Wisteria
floribunda) 		5 / 12 LEU A 137
ASP A 157
SER A 176
ILE A 177
VAL A 178
 None
CA  A 308 ( 2.2A)
None
None
None
 1.28A 6debB-5kxbA:
undetectable		 6debB-5kxbA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 5kxb WISTERIA FLORIBUNDA
AGGLUTININ
(Wisteria
floribunda) 		5 / 12 PRO A 133
ASP A 157
SER A 176
ILE A 177
VAL A 178
 None
CA  A 308 ( 2.2A)
None
None
None
 1.15A 6debB-5kxbA:
undetectable		 6debB-5kxbA:
14.35