SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kxf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5kxf FLOWERING TIME
CONTROL PROTEIN FPA
(Arabidopsis
thaliana) 		5 / 12 VAL A 557
LEU A 546
GLY A 523
ALA A 522
LEU A 483
 None
 1.12A 2aylA-5kxfA:
undetectable		 2aylA-5kxfA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 5kxf FLOWERING TIME
CONTROL PROTEIN FPA
(Arabidopsis
thaliana) 		5 / 12 VAL A 557
LEU A 546
GLY A 523
ALA A 522
LEU A 483
 None
 1.08A 3nt1A-5kxfA:
undetectable		 3nt1A-5kxfA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 5kxf FLOWERING TIME
CONTROL PROTEIN FPA
(Arabidopsis
thaliana) 		5 / 12 VAL A 557
LEU A 546
GLY A 523
ALA A 522
LEU A 483
 None
 1.07A 3nt1B-5kxfA:
undetectable		 3nt1B-5kxfA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 5kxf FLOWERING TIME
CONTROL PROTEIN FPA
(Arabidopsis
thaliana) 		4 / 6 SER A 517
ASP A 520
SER A 539
ASP A 540
 None
 1.21A 4eysA-5kxfA:
undetectable		 4eysA-5kxfA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 5kxf FLOWERING TIME
CONTROL PROTEIN FPA
(Arabidopsis
thaliana) 		5 / 5 GLU A 465
VAL A 496
LEU A 468
VAL A 472
PHE A 498
 None
 1.35A 4lb0B-5kxfA:
undetectable		 4lb0B-5kxfA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5kxf FLOWERING TIME
CONTROL PROTEIN FPA
(Arabidopsis
thaliana) 		5 / 10 VAL A 557
LEU A 546
GLY A 523
ALA A 522
LEU A 483
 None
 1.11A 4ph9A-5kxfA:
undetectable		 4ph9A-5kxfA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5kxf FLOWERING TIME
CONTROL PROTEIN FPA
(Arabidopsis
thaliana) 		5 / 10 VAL A 557
LEU A 546
GLY A 523
ALA A 522
LEU A 483
 None
 1.09A 4ph9B-5kxfA:
undetectable		 4ph9B-5kxfA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5kxf FLOWERING TIME
CONTROL PROTEIN FPA
(Arabidopsis
thaliana) 		5 / 9 VAL A 557
LEU A 546
GLY A 523
ALA A 522
LEU A 483
 None
 1.09A 4rs0A-5kxfA:
undetectable		 4rs0A-5kxfA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5kxf FLOWERING TIME
CONTROL PROTEIN FPA
(Arabidopsis
thaliana) 		5 / 12 VAL A 557
LEU A 546
GLY A 523
ALA A 522
LEU A 483
 None
 1.15A 5jvzB-5kxfA:
undetectable		 5jvzB-5kxfA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 5kxf FLOWERING TIME
CONTROL PROTEIN FPA
(Arabidopsis
thaliana) 		3 / 3 ARG A 456
ARG A 442
ASP A 501
 None
 0.92A 6d8pA-5kxfA:
undetectable		 6d8pA-5kxfA:
13.01