SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kxj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 5kxj L-ASPARTATE OXIDASE
(Salmonella
enterica) 		5 / 12 ILE A 500
VAL A 210
LEU A 443
ALA A 226
ILE A 474
 None
 0.99A 1epbA-5kxjA:
undetectable		 1epbA-5kxjA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5kxj L-ASPARTATE OXIDASE
(Salmonella
enterica) 		4 / 8 SER A 208
ASN A 241
GLN A 242
PHE A 243
 None
 1.24A 1p6kA-5kxjA:
undetectable		 1p6kA-5kxjA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5kxj L-ASPARTATE OXIDASE
(Salmonella
enterica) 		4 / 8 SER A 208
ASN A 241
GLN A 242
PHE A 243
 None
 1.22A 1p6kB-5kxjA:
undetectable		 1p6kB-5kxjA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5kxj L-ASPARTATE OXIDASE
(Salmonella
enterica) 		4 / 8 SER A 208
ASN A 241
GLN A 242
PHE A 243
 None
 1.23A 1rs6A-5kxjA:
undetectable		 1rs6A-5kxjA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 5kxj L-ASPARTATE OXIDASE
(Salmonella
enterica) 		5 / 12 HIS A 382
ALA A  82
GLY A  74
GLY A 383
LEU A 513
 None
 0.88A 1x1aA-5kxjA:
undetectable		 1x1aA-5kxjA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5kxj L-ASPARTATE OXIDASE
(Salmonella
enterica) 		4 / 8 SER A 208
ASN A 241
GLN A 242
PHE A 243
 None
 1.26A 1zzqA-5kxjA:
undetectable		 1zzqA-5kxjA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5kxj L-ASPARTATE OXIDASE
(Salmonella
enterica) 		4 / 8 SER A 208
ASN A 241
GLN A 242
PHE A 243
 None
 1.23A 1zzuB-5kxjA:
0.5		 1zzuB-5kxjA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		 5kxj L-ASPARTATE OXIDASE
(Salmonella
enterica) 		5 / 12 THR A 353
ASN A 241
ARG A 444
ALA A 350
THR A 214
 None
None
GOL  A 603 (-3.2A)
None
GOL  A 603 (-4.4A)
 1.37A 2axnA-5kxjA:
undetectable		 2axnA-5kxjA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5kxj L-ASPARTATE OXIDASE
(Salmonella
enterica) 		5 / 12 ALA A 207
SER A 208
ALA A 350
ALA A 497
GLY A 222
 None
 1.22A 2igtC-5kxjA:
undetectable		 2igtC-5kxjA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 5kxj L-ASPARTATE OXIDASE
(Salmonella
enterica) 		5 / 11 LEU A 202
ILE A  14
GLY A  15
GLY A  20
LEU A 370
 None
 1.00A 2qmmA-5kxjA:
undetectable
2qmmB-5kxjA:
undetectable		 2qmmA-5kxjA:
17.87
2qmmB-5kxjA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_1
(HIV-1 PROTEASE)		 5kxj L-ASPARTATE OXIDASE
(Salmonella
enterica) 		5 / 12 GLY A 266
ALA A 267
ASP A 312
PRO A 245
VAL A 293
 None
 1.03A 3d1zA-5kxjA:
undetectable		 3d1zA-5kxjA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 5kxj L-ASPARTATE OXIDASE
(Salmonella
enterica) 		3 / 3 ARG A 177
ASP A 164
GLN A 471
 None
EDO  A 607 (-3.6A)
None
 0.76A 3lcvB-5kxjA:
undetectable		 3lcvB-5kxjA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 5kxj L-ASPARTATE OXIDASE
(Salmonella
enterica) 		4 / 8 SER A 208
ASN A 241
GLN A 242
PHE A 243
 None
 1.25A 3n62B-5kxjA:
undetectable		 3n62B-5kxjA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5kxj L-ASPARTATE OXIDASE
(Salmonella
enterica) 		4 / 6 ASP A 312
ASP A 318
ASP A 338
GLU A 342
 None
 1.35A 4gkhJ-5kxjA:
undetectable		 4gkhJ-5kxjA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 5kxj L-ASPARTATE OXIDASE
(Salmonella
enterica) 		3 / 3 PRO A 174
LEU A 173
HIS A 196
 None
 0.66A 4pevA-5kxjA:
3.0		 4pevA-5kxjA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 5kxj L-ASPARTATE OXIDASE
(Salmonella
enterica) 		5 / 10 LEU A 370
LEU A 202
VAL A 235
LEU A 238
LEU A 499
 None
 1.13A 4po0A-5kxjA:
undetectable		 4po0A-5kxjA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 5kxj L-ASPARTATE OXIDASE
(Salmonella
enterica) 		5 / 12 ILE A 225
ALA A 226
ARG A 230
ALA A 162
ASN A 492
 None
None
EDO  A 607 (-3.6A)
None
None
 1.46A 4zo1X-5kxjA:
undetectable		 4zo1X-5kxjA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 5kxj L-ASPARTATE OXIDASE
(Salmonella
enterica) 		4 / 8 SER A 526
GLY A 527
ALA A  73
GLY A 383
 None
 0.87A 5albL-5kxjA:
undetectable		 5albL-5kxjA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 5kxj L-ASPARTATE OXIDASE
(Salmonella
enterica) 		4 / 5 SER A 199
VAL A 200
GLY A 181
ALA A 197
 None
 1.07A 5k50A-5kxjA:
undetectable		 5k50A-5kxjA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A220_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 5kxj L-ASPARTATE OXIDASE
(Salmonella
enterica) 		5 / 9 LEU A 202
VAL A 376
LEU A 499
THR A 365
VAL A 367
 None
 1.45A 5mxbA-5kxjA:
undetectable		 5mxbA-5kxjA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5kxj L-ASPARTATE OXIDASE
(Salmonella
enterica) 		5 / 9 LEU A 202
ILE A  14
GLY A  15
GLY A  20
LEU A 370
 None
 0.86A 5o96A-5kxjA:
undetectable
5o96B-5kxjA:
undetectable		 5o96A-5kxjA:
19.18
5o96B-5kxjA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 5kxj L-ASPARTATE OXIDASE
(Salmonella
enterica) 		5 / 12 LEU A 202
ILE A  14
GLY A  15
GLY A  20
LEU A 370
 None
 0.87A 5twjA-5kxjA:
undetectable		 5twjA-5kxjA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 5kxj L-ASPARTATE OXIDASE
(Salmonella
enterica) 		5 / 10 LEU A 202
ILE A  14
GLY A  15
GLY A  20
LEU A 370
 None
 0.93A 5twjB-5kxjA:
undetectable		 5twjB-5kxjA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 5kxj L-ASPARTATE OXIDASE
(Salmonella
enterica) 		3 / 3 ARG A 444
PRO A 217
TYR A 213
 GOL  A 603 (-3.2A)
GOL  A 603 ( 4.5A)
None
 1.03A 5tzoB-5kxjA:
undetectable		 5tzoB-5kxjA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 5kxj L-ASPARTATE OXIDASE
(Salmonella
enterica) 		4 / 6 LEU A  97
LYS A 138
GLU A 141
LEU A 144
 None
 1.30A 5xooA-5kxjA:
undetectable		 5xooA-5kxjA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 5kxj L-ASPARTATE OXIDASE
(Salmonella
enterica) 		5 / 12 GLY A 222
GLY A 224
VAL A 496
LEU A 499
ILE A 500
 None
 0.83A 6ectA-5kxjA:
undetectable		 6ectA-5kxjA:
22.56