SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kxq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 5kxq GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
1
(Mus
musculus) 		4 / 8 SER A 310
VAL A 335
HIS A 234
TYR A 239
 None
 0.97A 3fhxB-5kxqA:
2.0		 3fhxB-5kxqA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 5kxq GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
1
(Mus
musculus) 		3 / 3 ASP A 249
ASN A 252
SER A 317
 None
 0.99A 3lslA-5kxqA:
undetectable
3lslD-5kxqA:
undetectable		 3lslA-5kxqA:
19.70
3lslD-5kxqA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_B_STRB301_1
(STEROID RECEPTOR 2)		 5kxq GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
1
(Mus
musculus) 		5 / 12 LEU A  70
LEU A  40
LEU A 195
ALA A 196
TRP A 157
 None
 0.98A 4fn9B-5kxqA:
undetectable		 4fn9B-5kxqA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5kxq GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
1
(Mus
musculus) 		4 / 7 ASN A  67
LYS A  64
TYR A  42
LEU A  41
 NAG  A 401 (-1.8A)
None
None
None
 0.99A 4yv5A-5kxqA:
undetectable		 4yv5A-5kxqA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5kxq GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
1
(Mus
musculus) 		5 / 9 ARG A 237
GLY A 241
ALA A 308
VAL A 240
ILE A 356
 None
 1.43A 5i3cA-5kxqA:
undetectable		 5i3cA-5kxqA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5kxq GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
1
(Mus
musculus) 		5 / 12 SER A 174
LEU A 207
VAL A 206
GLY A  58
PHE A 132
 None
 1.41A 6a94A-5kxqA:
undetectable		 6a94A-5kxqA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5kxq GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
1
(Mus
musculus) 		4 / 6 GLY A  50
ASN A  51
ASP A  54
SER A 269
 GDP  A 403 (-3.3A)
None
None
None
 1.21A 6dwdA-5kxqA:
undetectable
6dwdC-5kxqA:
undetectable		 6dwdA-5kxqA:
21.47
6dwdC-5kxqA:
21.47