SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kym'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5kym 1-ACYL-SN-GLYCEROL-3
-PHOSPHATE
ACYLTRANSFERASE
(Thermotoga
maritima) 		4 / 5 PRO A 196
PRO A 161
GLY A 163
TYR A 192
 None
 1.02A 2jkjD-5kymA:
undetectable		 2jkjD-5kymA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5kym 1-ACYL-SN-GLYCEROL-3
-PHOSPHATE
ACYLTRANSFERASE
(Thermotoga
maritima) 		4 / 5 PRO A 196
PRO A 161
GLY A 163
TYR A 192
 None
 1.02A 2jkjF-5kymA:
undetectable		 2jkjF-5kymA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 5kym 1-ACYL-SN-GLYCEROL-3
-PHOSPHATE
ACYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 TYR A 117
TYR A  44
GLY A  25
 DD9  A 304 (-3.4A)
None
DD9  A 304 ( 3.9A)
 0.75A 3eteB-5kymA:
undetectable
3eteD-5kymA:
undetectable
3eteF-5kymA:
undetectable		 3eteB-5kymA:
20.16
3eteD-5kymA:
20.16
3eteF-5kymA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 5kym 1-ACYL-SN-GLYCEROL-3
-PHOSPHATE
ACYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 PHE A  13
TYR A  20
LEU A   8
 None
DD9  A 304 ( 4.7A)
None
 0.71A 3keeB-5kymA:
undetectable		 3keeB-5kymA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 5kym 1-ACYL-SN-GLYCEROL-3
-PHOSPHATE
ACYLTRANSFERASE
(Thermotoga
maritima) 		5 / 9 ILE A  49
LEU A 121
ILE A  93
PHE A 102
LYS A 105
 None
 1.49A 3sj4X-5kymA:
undetectable		 3sj4X-5kymA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5kym 1-ACYL-SN-GLYCEROL-3
-PHOSPHATE
ACYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 PHE A  13
TYR A  20
LEU A   8
 None
DD9  A 304 ( 4.7A)
None
 0.67A 3sueB-5kymA:
undetectable		 3sueB-5kymA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1507_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5kym 1-ACYL-SN-GLYCEROL-3
-PHOSPHATE
ACYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 ARG A 133
LYS A 133
ARG A 136
 None
 1.28A 3w1wA-5kymA:
undetectable
3w1wB-5kymA:
undetectable		 3w1wA-5kymA:
21.45
3w1wB-5kymA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5kym 1-ACYL-SN-GLYCEROL-3
-PHOSPHATE
ACYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 ARG A 136
ARG A 133
LYS A 133
 None
 1.37A 3w1wA-5kymA:
undetectable
3w1wB-5kymA:
undetectable		 3w1wA-5kymA:
21.45
3w1wB-5kymA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 5kym 1-ACYL-SN-GLYCEROL-3
-PHOSPHATE
ACYLTRANSFERASE
(Thermotoga
maritima) 		3 / 3 GLN A  85
THR A 191
ASP A  89
 None
 0.84A 5k9dA-5kymA:
undetectable		 5k9dA-5kymA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 5kym 1-ACYL-SN-GLYCEROL-3
-PHOSPHATE
ACYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 VAL A 153
ILE A  90
ILE A 103
LEU A 121
VAL A  97
 None
 0.98A 6ajiA-5kymA:
undetectable		 6ajiA-5kymA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5kym 1-ACYL-SN-GLYCEROL-3
-PHOSPHATE
ACYLTRANSFERASE
(Thermotoga
maritima) 		5 / 10 GLY A 205
VAL A  64
ASP A  63
THR A 191
ILE A 188
 None
 1.19A 6exiA-5kymA:
undetectable		 6exiA-5kymA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5kym 1-ACYL-SN-GLYCEROL-3
-PHOSPHATE
ACYLTRANSFERASE
(Thermotoga
maritima) 		5 / 10 GLY A 205
VAL A  64
ASP A  63
THR A 191
ILE A 188
 None
 1.14A 6exiB-5kymA:
undetectable		 6exiB-5kymA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5kym 1-ACYL-SN-GLYCEROL-3
-PHOSPHATE
ACYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 GLY A 205
VAL A  64
ASP A  63
THR A 191
ILE A 188
 None
 1.18A 6exiC-5kymA:
undetectable
6exiD-5kymA:
undetectable		 6exiC-5kymA:
14.63
6exiD-5kymA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5kym 1-ACYL-SN-GLYCEROL-3
-PHOSPHATE
ACYLTRANSFERASE
(Thermotoga
maritima) 		5 / 12 GLY A 205
VAL A  64
ASP A  63
THR A 191
ILE A 188
 None
 1.16A 6exiC-5kymA:
undetectable
6exiD-5kymA:
undetectable		 6exiC-5kymA:
14.63
6exiD-5kymA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5kym 1-ACYL-SN-GLYCEROL-3
-PHOSPHATE
ACYLTRANSFERASE
(Thermotoga
maritima) 		4 / 6 LEU A  92
VAL A 181
PHE A  96
GLY A  53
 None
 1.06A 6hd4B-5kymA:
2.2		 6hd4B-5kymA:
16.52