SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kyv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 5kyv LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		5 / 12 LEU A  96
ILE A 192
ALA A 193
ALA A 215
THR A 346
 None
 0.97A 1cbsA-5kyvA:
undetectable		 1cbsA-5kyvA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 5kyv LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		4 / 6 PRO A 481
ASP A 474
ASP A 476
TYR A 444
 None
 1.21A 1hpkA-5kyvA:
undetectable		 1hpkA-5kyvA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_2
(ANGIOTENSIN
CONVERTING ENZYME)		 5kyv LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		4 / 4 ARG A 337
ALA A 285
SER A 284
TYR A 255
 None
None
TLA  A 602 ( 4.8A)
None
 1.42A 1j36A-5kyvA:
0.0		 1j36A-5kyvA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_2
(ANGIOTENSIN
CONVERTING ENZYME)		 5kyv LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		4 / 4 ARG A 337
ALA A 285
SER A 284
TYR A 255
 None
None
TLA  A 602 ( 4.8A)
None
 1.42A 1j36B-5kyvA:
0.0		 1j36B-5kyvA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 5kyv LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		5 / 9 GLY A  23
ALA A  22
LEU A  96
PHE A 219
LEU A 194
 None
 1.02A 1y7iA-5kyvA:
undetectable		 1y7iA-5kyvA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 5kyv LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		5 / 12 LEU A  96
ILE A 192
ALA A 193
ALA A 215
THR A 346
 None
 1.02A 2fr3A-5kyvA:
undetectable		 2fr3A-5kyvA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5kyv LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		3 / 3 SER A 163
GLN A 162
PHE A 167
 None
 0.68A 3g4lC-5kyvA:
undetectable		 3g4lC-5kyvA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5kyv LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		4 / 8 LEU A 350
GLY A 394
PRO A 395
MET A 396
 None
 1.11A 3hcrA-5kyvA:
2.4		 3hcrA-5kyvA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5kyv LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		3 / 3 CYH A 216
PRO A  16
ASP A  19
 None
 0.93A 3hlwB-5kyvA:
undetectable		 3hlwB-5kyvA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 5kyv LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		4 / 7 ILE A 257
LEU A  96
THR A 346
ARG A 213
 None
 1.06A 3nxuA-5kyvA:
undetectable		 3nxuA-5kyvA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 5kyv LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		4 / 5 ILE A 397
THR A 345
THR A 346
PHE A 369
 None
 0.90A 3snfA-5kyvA:
undetectable		 3snfA-5kyvA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 5kyv LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		5 / 9 ALA A 296
GLY A 324
ILE A 336
PRO A 289
THR A 290
 None
 1.22A 3spkA-5kyvA:
undetectable		 3spkA-5kyvA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5kyv LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		3 / 3 ARG A 337
ARG A 218
ASP A 224
 None
SLU  A 601 ( 4.2A)
None
 0.95A 3wipG-5kyvA:
undetectable
3wipH-5kyvA:
undetectable		 3wipG-5kyvA:
17.64
3wipH-5kyvA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_F_5FWF1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5kyv LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		4 / 6 GLU A 370
LYS A   9
LYS A 372
TRP A 417
 None
 1.38A 4a7tF-5kyvA:
undetectable		 4a7tF-5kyvA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5kyv LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		4 / 8 ARG A 218
ILE A 351
VAL A 366
GLY A 341
 SLU  A 601 ( 4.2A)
None
None
SLU  A 601 (-4.0A)
 0.94A 4eq4B-5kyvA:
9.8		 4eq4B-5kyvA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5kyv LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		4 / 6 ILE A 241
PRO A 242
PHE A 243
PHE A  89
 None
 1.06A 4fgkA-5kyvA:
4.1		 4fgkA-5kyvA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_B_CLQB303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5kyv LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		5 / 11 HIS A 310
GLN A 283
ILE A 232
GLY A 259
TYR A  53
 None
 1.46A 4fglA-5kyvA:
4.3
4fglB-5kyvA:
3.6		 4fglA-5kyvA:
20.36
4fglB-5kyvA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 5kyv LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		4 / 8 ILE A 150
ILE A  78
ALA A  95
VAL A 168
 None
 0.77A 4jltA-5kyvA:
undetectable		 4jltA-5kyvA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 5kyv LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		3 / 3 CYH A 216
PRO A  16
ASP A  19
 None
 0.86A 4pm5A-5kyvA:
undetectable		 4pm5A-5kyvA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5kyv LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		4 / 7 ILE A 434
GLY A 341
THR A 345
LEU A 418
 SLU  A 601 ( 4.3A)
SLU  A 601 (-4.0A)
None
None
 0.91A 4zdzA-5kyvA:
undetectable		 4zdzA-5kyvA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5kyv LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		4 / 7 ILE A 434
GLY A 341
THR A 345
LEU A 418
 SLU  A 601 ( 4.3A)
SLU  A 601 (-4.0A)
None
None
 0.85A 4ze3A-5kyvA:
undetectable		 4ze3A-5kyvA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5kyv LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		4 / 7 ILE A 434
GLY A 341
THR A 345
LEU A 418
 SLU  A 601 ( 4.3A)
SLU  A 601 (-4.0A)
None
None
 0.90A 5esmA-5kyvA:
undetectable		 5esmA-5kyvA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5kyv LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		3 / 3 MET A 118
GLN A 122
ARG A  77
 None
 1.11A 5ewzB-5kyvA:
undetectable		 5ewzB-5kyvA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5kyv LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		4 / 8 ILE A 434
GLY A 341
THR A 345
LEU A 418
 SLU  A 601 ( 4.3A)
SLU  A 601 (-4.0A)
None
None
 0.86A 5hs1A-5kyvA:
undetectable		 5hs1A-5kyvA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5kyv LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		3 / 3 VAL A 366
SER A 347
MET A 398
 None
SLU  A 601 (-3.5A)
None
 0.84A 5ikqA-5kyvA:
undetectable		 5ikqA-5kyvA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 5kyv LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		4 / 7 LEU A 390
THR A 345
ILE A 397
LEU A 418
 None
 1.01A 5te8A-5kyvA:
undetectable		 5te8A-5kyvA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 5kyv LUCIFERIN
4-MONOOXYGENASE
(Photinus
pyralis) 		5 / 10 LEU A 238
ALA A 285
LEU A 287
ILE A 301
LEU A 333
 None
 1.28A 6cbzB-5kyvA:
undetectable		 6cbzB-5kyvA:
11.00