SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kz5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5kz5 CYSTEINE
DESULFURASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 LEU 1 199
THR 1 174
CYH 1 163
TYR 1 175
 None
 1.33A 1uw6P-5kz51:
undetectable
1uw6T-5kz51:
undetectable		 1uw6P-5kz51:
20.37
1uw6T-5kz51:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 5kz5 CYSTEINE
DESULFURASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 PRO 1  68
GLY 1 411
TYR 1 260
 None
 0.57A 2vouA-5kz51:
undetectable		 2vouA-5kz51:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 5kz5 CYSTEINE
DESULFURASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 PRO 1  68
GLY 1 411
TYR 1 260
 None
 0.55A 2vouB-5kz51:
undetectable		 2vouB-5kz51:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 5kz5 CYSTEINE
DESULFURASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 PRO 1  68
GLY 1 411
TYR 1 260
 None
 0.57A 2vouC-5kz51:
undetectable		 2vouC-5kz51:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_2
(HIV-1 PROTEASE)		 5kz5 CYSTEINE
DESULFURASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 VAL 1 278
ILE 1 268
GLY 1 266
VAL 1 265
ILE 1 122
 None
 1.02A 3oxvB-5kz51:
undetectable		 3oxvB-5kz51:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_2
(HIV-1 PROTEASE)		 5kz5 CYSTEINE
DESULFURASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 VAL 1 278
ILE 1 268
GLY 1 266
VAL 1 265
ILE 1 122
 None
 1.09A 3oxvD-5kz51:
undetectable		 3oxvD-5kz51:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 5kz5 FRATAXIN,
MITOCHONDRIAL
IRON-SULFUR CLUSTER
ASSEMBLY ENZYME
ISCU, MITOCHONDRIAL
(Homo
sapiens;
Homo
sapiens) 		4 / 6 GLY A 207
GLU A 184
ASP A 178
GLU a 165
 None
 1.01A 3vywC-5kz5A:
undetectable		 3vywC-5kz5A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5kz5 CYSTEINE
DESULFURASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 GLU 1 416
TYR 1 317
HIS 1 319
VAL 1 310
 None
 0.93A 4a97A-5kz51:
undetectable		 4a97A-5kz51:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5kz5 CYSTEINE
DESULFURASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 GLU 1 416
TYR 1 317
HIS 1 319
VAL 1 310
 None
 0.94A 4a97D-5kz51:
undetectable		 4a97D-5kz51:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5kz5 CYSTEINE
DESULFURASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 GLU 1 416
TYR 1 317
HIS 1 319
VAL 1 310
 None
 0.94A 4a97I-5kz51:
undetectable		 4a97I-5kz51:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA611_0
(SERUM ALBUMIN)		 5kz5 FRATAXIN,
MITOCHONDRIAL
IRON-SULFUR CLUSTER
ASSEMBLY ENZYME
ISCU, MITOCHONDRIAL
(Homo
sapiens;
Homo
sapiens) 		4 / 4 LYS a 127
SER A 201
LEU A 200
ALA A 187
 None
 1.16A 5dbyA-5kz5a:
0.0		 5dbyA-5kz5a:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5kz5 IRON-SULFUR CLUSTER
ASSEMBLY ENZYME
ISCU, MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ILE a  77
ALA a 105
THR a 106
VAL a 109
 None
 0.71A 5eclD-5kz5a:
undetectable		 5eclD-5kz5a:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5kz5 IRON-SULFUR CLUSTER
ASSEMBLY ENZYME
ISCU, MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ALA a 126
THR a 123
LYS a 121
GLU a 143
 None
 1.21A 5ecnA-5kz5a:
undetectable		 5ecnA-5kz5a:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 5kz5 CYSTEINE
DESULFURASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ALA 1 233
ILE 1 184
VAL 1 211
ALA 1 236
GLN 1 235
 None
 1.19A 5nukA-5kz51:
undetectable		 5nukA-5kz51:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 5kz5 FRATAXIN,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 PHE A 127
PHE A 110
LEU A 106
LEU A 136
 None
 1.27A 5veuH-5kz5A:
undetectable		 5veuH-5kz5A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 5kz5 FRATAXIN,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 TRP A 168
LEU A 203
TYR A 205
THR A 102
 None
 1.23A 6c71B-5kz5A:
undetectable		 6c71B-5kz5A:
16.77