SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kzd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 5kzd N-ACETYLNEURAMINATE
LYASE
(Staphylococcus
aureus) 		5 / 11 LEU A   8
GLY A   7
LEU A 187
LEU A 185
LEU A 194
 None
 1.30A 1mx1B-5kzdA:
undetectable		 1mx1B-5kzdA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 5kzd N-ACETYLNEURAMINATE
LYASE
(Staphylococcus
aureus) 		5 / 12 GLY A  82
ASN A  46
ILE A 126
LEU A  84
ILE A  90
 None
 1.06A 4aztA-5kzdA:
undetectable		 4aztA-5kzdA:
19.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 5kzd N-ACETYLNEURAMINATE
LYASE
(Staphylococcus
aureus) 		5 / 10 GLY A 189
ASP A 191
GLU A 192
GLY A 207
SER A 208
 RCJ  A 301 (-3.6A)
RCJ  A 301 (-2.5A)
RCJ  A 301 (-3.1A)
RCJ  A 301 (-3.2A)
RCJ  A 301 (-3.2A)
 0.37A 4bwlC-5kzdA:
39.4		 4bwlC-5kzdA:
36.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 5kzd N-ACETYLNEURAMINATE
LYASE
(Staphylococcus
aureus) 		5 / 12 ALA A  10
LEU A 255
SER A 239
ILE A 243
LEU A 247
 None
None
None
RCJ  A 301 (-4.6A)
RCJ  A 301 ( 4.7A)
 1.10A 4ky8C-5kzdA:
undetectable		 4ky8C-5kzdA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5kzd N-ACETYLNEURAMINATE
LYASE
(Staphylococcus
aureus) 		5 / 10 LEU A  40
ALA A  34
LEU A  43
GLY A  50
LEU A  13
 None
 1.38A 5dx3A-5kzdA:
undetectable		 5dx3A-5kzdA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZP_A_CFFA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 5kzd N-ACETYLNEURAMINATE
LYASE
(Staphylococcus
aureus) 		5 / 9 ILE A 242
GLU A  38
LEU A 259
ASN A  33
ILE A 258
 None
 1.46A 5mzpA-5kzdA:
1.0		 5mzpA-5kzdA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5kzd N-ACETYLNEURAMINATE
LYASE
(Staphylococcus
aureus) 		4 / 6 PHE A 276
LEU A 287
LEU A 284
HIS A 280
 None
 0.83A 6e43A-5kzdA:
undetectable		 6e43A-5kzdA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5kzd N-ACETYLNEURAMINATE
LYASE
(Staphylococcus
aureus) 		4 / 6 PHE A 276
LEU A 287
LEU A 284
HIS A 280
 None
 0.85A 6e43B-5kzdA:
undetectable		 6e43B-5kzdA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5kzd N-ACETYLNEURAMINATE
LYASE
(Staphylococcus
aureus) 		4 / 6 PHE A 276
LEU A 287
LEU A 284
HIS A 280
 None
 0.83A 6e43C-5kzdA:
undetectable		 6e43C-5kzdA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5kzd N-ACETYLNEURAMINATE
LYASE
(Staphylococcus
aureus) 		4 / 6 PHE A 276
LEU A 287
LEU A 284
HIS A 280
 None
 0.85A 6e43D-5kzdA:
undetectable		 6e43D-5kzdA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 5kzd N-ACETYLNEURAMINATE
LYASE
(Staphylococcus
aureus) 		4 / 7 ALA A 266
GLY A 267
LEU A 268
GLY A  50
 None
 0.70A 6nm4A-5kzdA:
undetectable		 6nm4A-5kzdA:
20.20