SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kzl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 5kzl HEME OXYGENASE
(Leptospira
interrogans) 		3 / 3 PHE A  69
LEU A  55
SER A 122
 None
 0.93A 1e7aA-5kzlA:
undetectable		 1e7aA-5kzlA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5kzl HEME OXYGENASE
(Leptospira
interrogans) 		4 / 6 SER A  97
THR A 100
GLU A 204
GLY A 200
 None
 1.16A 1kqbC-5kzlA:
undetectable
1kqbD-5kzlA:
undetectable		 1kqbC-5kzlA:
23.87
1kqbD-5kzlA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 5kzl HEME OXYGENASE
(Leptospira
interrogans) 		3 / 3 ALA A 120
HIS A 121
VAL A 124
 None
None
HEM  A 301 (-4.4A)
 0.42A 1lqtB-5kzlA:
undetectable		 1lqtB-5kzlA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 5kzl HEME OXYGENASE
(Leptospira
interrogans) 		3 / 3 ALA A 120
HIS A 121
VAL A 124
 None
None
HEM  A 301 (-4.4A)
 0.44A 1lquB-5kzlA:
undetectable		 1lquB-5kzlA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 5kzl HEME OXYGENASE
(Leptospira
interrogans) 		4 / 7 ALA A 173
TYR A 170
TYR A  68
PHE A 166
 None
 1.14A 2ajvH-5kzlA:
undetectable
2ajvL-5kzlA:
undetectable		 2ajvH-5kzlA:
20.94
2ajvL-5kzlA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 5kzl HEME OXYGENASE
(Leptospira
interrogans) 		4 / 4 VAL A 124
ARG A 106
ILE A 201
THR A  11
 HEM  A 301 (-4.4A)
None
None
None
 1.32A 3cl9A-5kzlA:
undetectable		 3cl9A-5kzlA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 5kzl HEME OXYGENASE
(Leptospira
interrogans) 		5 / 12 GLY A 133
LEU A 136
ALA A 140
LEU A  41
ASP A  81
 None
HEM  A 301 (-4.7A)
None
None
None
 0.98A 3gwvA-5kzlA:
2.8		 3gwvA-5kzlA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5kzl HEME OXYGENASE
(Leptospira
interrogans) 		4 / 7 TYR A  45
VAL A 194
VAL A 104
ILE A 201
 None
 0.90A 3mssB-5kzlA:
undetectable		 3mssB-5kzlA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 5kzl HEME OXYGENASE
(Leptospira
interrogans) 		3 / 3 ARG A 171
LEU A 127
THR A  11
 None
HEM  A 301 ( 4.4A)
None
 0.63A 3oxcA-5kzlA:
undetectable		 3oxcA-5kzlA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 5kzl HEME OXYGENASE
(Leptospira
interrogans) 		4 / 6 TYR A  45
VAL A 194
VAL A 104
ILE A 201
 None
 0.90A 3pyyA-5kzlA:
undetectable		 3pyyA-5kzlA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5kzl HEME OXYGENASE
(Leptospira
interrogans) 		4 / 8 MET A  51
GLU A  52
GLU A  49
TYR A  46
 None
 1.06A 4mj8A-5kzlA:
undetectable
4mj8C-5kzlA:
undetectable		 4mj8A-5kzlA:
23.77
4mj8C-5kzlA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5kzl HEME OXYGENASE
(Leptospira
interrogans) 		4 / 8 MET A  51
GLU A  52
GLU A  49
TYR A  46
 None
 1.02A 4mj8B-5kzlA:
undetectable
4mj8C-5kzlA:
undetectable		 4mj8B-5kzlA:
23.77
4mj8C-5kzlA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5kzl HEME OXYGENASE
(Leptospira
interrogans) 		4 / 7 MET A  51
GLU A  52
GLU A  49
TYR A  46
 None
 1.07A 4mj8C-5kzlA:
undetectable		 4mj8C-5kzlA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 5kzl HEME OXYGENASE
(Leptospira
interrogans) 		4 / 8 LEU A 127
VAL A 194
SER A 191
HIS A 121
 HEM  A 301 ( 4.4A)
None
None
None
 1.15A 4qknA-5kzlA:
undetectable		 4qknA-5kzlA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5kzl HEME OXYGENASE
(Leptospira
interrogans) 		4 / 5 ILE A 160
PHE A 166
ASN A  58
TYR A  68
 None
 1.10A 6a93B-5kzlA:
undetectable		 6a93B-5kzlA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 5kzl HEME OXYGENASE
(Leptospira
interrogans) 		3 / 3 LYS A 184
VAL A 179
ASP A 181
 None
 0.58A 6fgdA-5kzlA:
undetectable		 6fgdA-5kzlA:
17.84