SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kzm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)
5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN

(Francisella
tularensis)
5 / 11 LEU B 186
ALA B  97
LEU B 125
ALA B 121
THR B 118
None
1.12A 1ictA-5kzmB:
undetectable
1ictC-5kzmB:
undetectable
1ictA-5kzmB:
14.94
1ictC-5kzmB:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)
5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN

(Francisella
tularensis)
5 / 12 GLY B 231
VAL B 308
ALA B 301
SER B 300
SER B 296
LLP  B  86 ( 3.7A)
None
None
None
CA  B 402 (-4.2A)
1.38A 1nbhA-5kzmB:
2.2
1nbhA-5kzmB:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)
5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN

(Francisella
tularensis)
5 / 12 GLY B 231
VAL B 308
ALA B 301
SER B 300
SER B 296
LLP  B  86 ( 3.7A)
None
None
None
CA  B 402 (-4.2A)
1.38A 1nbhD-5kzmB:
undetectable
1nbhD-5kzmB:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)
5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN
TRYPTOPHAN SYNTHASE
BETA CHAIN

(Francisella
tularensis)
4 / 8 TYR A 116
GLN A 151
HIS A 135
TYR B   7
None
1.26A 1nx9A-5kzmA:
undetectable
1nx9A-5kzmA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)
5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN
TRYPTOPHAN SYNTHASE
BETA CHAIN

(Francisella
tularensis)
4 / 8 TYR A 116
GLN A 151
HIS A 135
TYR B   7
None
1.27A 1nx9B-5kzmA:
undetectable
1nx9B-5kzmA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)
5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN
TRYPTOPHAN SYNTHASE
BETA CHAIN

(Francisella
tularensis)
4 / 8 TYR A 116
GLN A 151
HIS A 135
TYR B   7
None
1.27A 1nx9C-5kzmA:
undetectable
1nx9C-5kzmA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)
5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN
TRYPTOPHAN SYNTHASE
BETA CHAIN

(Francisella
tularensis)
4 / 8 TYR A 116
GLN A 151
HIS A 135
TYR B   7
None
1.26A 1nx9D-5kzmA:
undetectable
1nx9D-5kzmA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN

(Francisella
tularensis)
4 / 6 LEU B 358
ARG B  62
THR B  59
LEU B  74
None
1.02A 1v54A-5kzmB:
undetectable
1v54J-5kzmB:
undetectable
1v54A-5kzmB:
21.21
1v54J-5kzmB:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)
5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN

(Francisella
tularensis)
3 / 3 LYS B  41
ASP B 242
ASP B 245
None
1.16A 2br4A-5kzmB:
undetectable
2br4A-5kzmB:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1100_1
(SERUM ALBUMIN)
5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN

(Francisella
tularensis)
4 / 6 HIS B 314
TYR B 323
ARG B 320
GLY B 319
None
1.48A 2i30A-5kzmB:
undetectable
2i30A-5kzmB:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)
5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Francisella
tularensis)
5 / 12 GLY A  99
GLY A 173
LEU A 102
ASP A 125
VAL A 124
None
1.03A 2oxtC-5kzmA:
undetectable
2oxtC-5kzmA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)
5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Francisella
tularensis)
5 / 11 ASN A  69
ILE A  37
THR A 257
VAL A 260
PRO A  22
None
1.20A 3a51A-5kzmA:
undetectable
3a51A-5kzmA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)
5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Francisella
tularensis)
5 / 12 ASN A  69
ILE A  37
THR A 257
VAL A 260
PRO A  22
None
1.22A 3a51B-5kzmA:
undetectable
3a51B-5kzmA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)
5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Francisella
tularensis)
5 / 12 ASN A  69
ILE A  37
THR A 257
VAL A 260
PRO A  22
None
1.18A 3a51C-5kzmA:
undetectable
3a51C-5kzmA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)
5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Francisella
tularensis)
5 / 12 ASN A  69
ILE A  37
THR A 257
VAL A 260
PRO A  22
None
1.21A 3a51D-5kzmA:
undetectable
3a51D-5kzmA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)
5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN

(Francisella
tularensis)
4 / 8 ALA B  97
LEU B  96
GLN B  26
MET B 100
None
0.85A 3cldB-5kzmB:
undetectable
3cldB-5kzmB:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)
5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Francisella
tularensis)
3 / 3 ARG A  90
ILE A  26
THR A 238
None
0.72A 3ia4D-5kzmA:
undetectable
3ia4D-5kzmA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)
5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN
TRYPTOPHAN SYNTHASE
BETA CHAIN

(Francisella
tularensis)
5 / 12 GLU B 295
PHE B 305
GLY B 231
ALA B 283
ASP A  57
CA  B 402 (-3.2A)
None
LLP  B  86 ( 3.7A)
None
None
1.32A 3jzjA-5kzmB:
1.5
3jzjA-5kzmB:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_A_T44A128_1
(TRANSTHYRETIN)
5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN

(Francisella
tularensis)
5 / 9 LEU B 125
THR B  87
ALA B 121
LEU B 127
THR B 118
None
LLP  B  86 ( 4.4A)
None
None
None
1.20A 3ozkA-5kzmB:
undetectable
3ozkA-5kzmB:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_1
(PROTEASE)
5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Francisella
tularensis)
5 / 9 GLY A 123
ALA A 122
ASP A 121
ILE A 127
ILE A  26
None
0.97A 3s53A-5kzmA:
undetectable
3s53A-5kzmA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)
5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN

(Francisella
tularensis)
4 / 8 PHE B 278
ALA B 283
ALA B 191
THR B 189
None
None
None
LLP  B  86 ( 3.8A)
1.05A 3t3sE-5kzmB:
undetectable
3t3sE-5kzmB:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)
5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Francisella
tularensis)
4 / 6 SER A 126
TYR A 174
VAL A 210
THR A   6
None
1.15A 3tneA-5kzmA:
undetectable
3tneA-5kzmA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)
5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN

(Francisella
tularensis)
5 / 12 LEU B 270
ALA B 283
THR B 198
ALA B 190
ILE B 237
None
1.16A 3ut5B-5kzmB:
undetectable
3ut5B-5kzmB:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN
TRYPTOPHAN SYNTHASE
BETA CHAIN

(Francisella
tularensis)
4 / 5 GLU A 139
GLU A 136
TYR B   7
HIS B 314
None
1.39A 4a97J-5kzmA:
undetectable
4a97J-5kzmA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)
5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Francisella
tularensis)
5 / 12 GLY A 231
ALA A 224
PHE A  20
ILE A  21
LEU A 177
None
1.26A 4azsA-5kzmA:
undetectable
4azsA-5kzmA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)
5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Francisella
tularensis)
5 / 12 GLY A 231
ALA A 224
PHE A  20
ILE A  21
LEU A 177
None
1.25A 4azwA-5kzmA:
undetectable
4azwA-5kzmA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BB2_B_STRB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)
5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN

(Francisella
tularensis)
5 / 11 ALA B 334
SER B 351
GLN B 369
THR B  70
ILE B 227
None
1.38A 4bb2A-5kzmB:
undetectable
4bb2B-5kzmB:
undetectable
4bb2A-5kzmB:
22.28
4bb2B-5kzmB:
6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)
5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Francisella
tularensis)
5 / 10 ILE A  85
ALA A  32
THR A  40
LEU A 256
ILE A  38
None
1.17A 4km0A-5kzmA:
undetectable
4km0A-5kzmA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)
5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN

(Francisella
tularensis)
4 / 7 VAL B 200
ILE B 199
LEU B  20
LEU B  24
None
0.56A 4l1wA-5kzmB:
undetectable
4l1wA-5kzmB:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)
5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Francisella
tularensis)
5 / 12 VAL A 221
ALA A 224
PHE A 259
PHE A  20
GLY A 231
None
1.34A 4mm4A-5kzmA:
undetectable
4mm4A-5kzmA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)
5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Francisella
tularensis)
5 / 12 ASP A  39
TYR A  93
VAL A 260
SER A  43
GLY A  45
None
1.29A 4mm6A-5kzmA:
undetectable
4mm6A-5kzmA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)
5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN
TRYPTOPHAN SYNTHASE
BETA CHAIN

(Francisella
tularensis;
Francisella
tularensis)
5 / 12 PRO B 269
MET B 286
ASN A 105
ALA A 109
GLY B 291
None
1.36A 4oadA-5kzmB:
undetectable
4oadA-5kzmB:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)
5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Francisella
tularensis)
5 / 12 GLU A  50
ASP A 131
ASP A  61
LEU A 106
GLY A  52
None
1.46A 4pgfB-5kzmA:
undetectable
4pgfB-5kzmA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)
5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN

(Francisella
tularensis)
5 / 12 LEU B  24
VAL B  16
PRO B 193
PHE B   8
GLY B 233
None
None
None
None
LLP  B  86 ( 3.1A)
1.29A 4q15A-5kzmB:
2.3
4q15A-5kzmB:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)
5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN

(Francisella
tularensis)
5 / 12 LEU B  24
VAL B  16
PRO B 193
PHE B   8
GLY B 233
None
None
None
None
LLP  B  86 ( 3.1A)
1.28A 4q15B-5kzmB:
2.2
4q15B-5kzmB:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)
5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Francisella
tularensis)
5 / 11 ASP A  39
TYR A  93
VAL A 260
SER A  43
GLY A  45
None
1.25A 4xnxA-5kzmA:
undetectable
4xnxA-5kzmA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)
5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Francisella
tularensis)
5 / 11 ASN A  69
ILE A  65
THR A 238
GLY A 235
ASP A  61
None
1.25A 4xt7A-5kzmA:
undetectable
4xt7A-5kzmA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)
5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN

(Francisella
tularensis)
5 / 12 GLY B 379
THR B 385
ASP B 380
ILE B 344
LEU B 348
None
None
ACT  B 401 (-3.0A)
None
None
1.17A 5bw4A-5kzmB:
2.9
5bw4A-5kzmB:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)
5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN

(Francisella
tularensis)
5 / 12 ASP B 382
LEU B 120
ALA B  84
SER B 376
THR B 118
None
None
LLP  B  86 ( 4.0A)
LLP  B  86 ( 2.8A)
None
1.29A 5hnzB-5kzmB:
undetectable
5hnzB-5kzmB:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)
5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Francisella
tularensis)
5 / 12 GLY A 173
GLY A  99
LEU A  51
GLY A 231
VAL A 210
None
0.84A 5i71A-5kzmA:
undetectable
5i71A-5kzmA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)
5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Francisella
tularensis)
5 / 12 ILE A  21
GLY A 173
GLY A  99
LEU A  51
VAL A 210
None
0.81A 5i71A-5kzmA:
undetectable
5i71A-5kzmA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)
5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Francisella
tularensis)
5 / 12 GLY A 173
GLY A  99
LEU A  51
GLY A 231
VAL A 210
None
0.86A 5i73A-5kzmA:
undetectable
5i73A-5kzmA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)
5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Francisella
tularensis)
5 / 12 ILE A  21
GLY A 173
GLY A  99
LEU A  51
VAL A 210
None
0.77A 5i73A-5kzmA:
undetectable
5i73A-5kzmA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)
5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Francisella
tularensis)
5 / 12 GLY A 173
GLY A  99
LEU A  51
GLY A 231
VAL A 210
None
0.85A 5i75A-5kzmA:
undetectable
5i75A-5kzmA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)
5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Francisella
tularensis)
5 / 12 ILE A  21
GLY A 173
GLY A  99
LEU A  51
VAL A 210
None
0.79A 5i75A-5kzmA:
undetectable
5i75A-5kzmA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)
5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN

(Francisella
tularensis)
5 / 12 LEU B 285
LEU B 165
PHE B 278
PHE B 279
ALA B 191
None
1.13A 5iepA-5kzmB:
undetectable
5iepA-5kzmB:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)
5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN

(Francisella
tularensis)
5 / 12 LEU B 270
ALA B 283
THR B 198
ALA B 190
ILE B 237
None
1.03A 5itzB-5kzmB:
undetectable
5itzB-5kzmB:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)
5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN

(Francisella
tularensis)
5 / 12 LEU B 270
ALA B 283
THR B 198
ALA B 190
ILE B 237
None
1.06A 5mioB-5kzmB:
2.5
5mioB-5kzmB:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)
5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Francisella
tularensis)
5 / 9 VAL A 124
ILE A  53
LEU A 100
ILE A  26
PHE A  83
None
0.98A 5nunA-5kzmA:
undetectable
5nunA-5kzmA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)
5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN

(Francisella
tularensis)
4 / 8 ILE B 344
GLU B  77
ALA B  57
THR B  56
None
0.69A 5og9A-5kzmB:
undetectable
5og9A-5kzmB:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)
5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN

(Francisella
tularensis)
5 / 12 LEU B  24
VAL B  16
PRO B 193
PHE B   8
GLY B 233
None
None
None
None
LLP  B  86 ( 3.1A)
1.27A 5xipA-5kzmB:
undetectable
5xipA-5kzmB:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)
5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN

(Francisella
tularensis)
5 / 12 LEU B  24
VAL B  16
PRO B 193
PHE B   8
GLY B 233
None
None
None
None
LLP  B  86 ( 3.1A)
1.25A 5xipC-5kzmB:
undetectable
5xipC-5kzmB:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))
5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN

(Francisella
tularensis)
5 / 12 LEU B  24
VAL B  16
PRO B 193
PHE B   8
GLY B 233
None
None
None
None
LLP  B  86 ( 3.1A)
1.27A 5xiqD-5kzmB:
undetectable
5xiqD-5kzmB:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)
5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN

(Francisella
tularensis)
5 / 12 LEU B 358
ALA B 334
LEU B 338
THR B  59
ALA B 357
None
1.27A 5xiwD-5kzmB:
undetectable
5xiwD-5kzmB:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)
5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN

(Francisella
tularensis)
3 / 3 SER B 298
SER B 300
ALA B 353
None
0.70A 6dwnC-5kzmB:
undetectable
6dwnC-5kzmB:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)
5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN

(Francisella
tularensis)
4 / 6 LEU B  80
THR B  87
GLY B  82
ARG B 378
None
LLP  B  86 ( 4.4A)
None
None
1.12A 6gtqB-5kzmB:
0.0
6gtqD-5kzmB:
undetectable
6gtqB-5kzmB:
20.88
6gtqD-5kzmB:
7.41