SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kzn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 12 LEU A  62
PHE A  38
LEU A  26
ILE A 378
VAL A 385
 None
 1.18A 1hrkA-5kznA:
4.6		 1hrkA-5kznA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 12 LEU A  62
PHE A  38
LEU A  26
ILE A 378
VAL A 385
 None
 1.16A 1hrkB-5kznA:
4.6		 1hrkB-5kznA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 11 ALA A 266
ALA A 275
SER A 294
THR A 270
VAL A 241
 None
 1.25A 1ictA-5kznA:
undetectable
1ictC-5kznA:
undetectable		 1ictA-5kznA:
12.22
1ictC-5kznA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 10 ILE A  88
GLY A  35
GLU A  29
GLY A  30
ARG A  83
 None
 1.11A 1mehA-5kznA:
undetectable		 1mehA-5kznA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 11 SER A 212
LEU A 278
VAL A 254
VAL A 210
THR A 270
 None
 1.35A 1q23F-5kznA:
undetectable		 1q23F-5kznA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		4 / 6 LEU A 278
ALA A 281
LEU A 279
SER A 307
 None
 1.29A 1tyrA-5kznA:
undetectable		 1tyrA-5kznA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		3 / 3 GLN A 159
ILE A 160
TYR A 180
 None
 0.75A 1vifA-5kznA:
undetectable		 1vifA-5kznA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		4 / 6 LEU A  37
LEU A 155
ILE A 136
HIS A  87
 None
 0.95A 1yajF-5kznA:
undetectable		 1yajF-5kznA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_A_STRA301_1
(MINERALOCORTICOID
RECEPTOR)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 12 ASN A 153
LEU A 155
ALA A 152
GLN A 162
LEU A  37
 None
 1.13A 2aa5A-5kznA:
undetectable		 2aa5A-5kznA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 12 ASN A 153
LEU A 155
ALA A 152
GLN A 162
LEU A  37
 None
 1.11A 2aa5B-5kznA:
undetectable		 2aa5B-5kznA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 12 LEU A 155
ALA A 152
GLN A 162
SER A 148
LEU A  37
 None
 1.36A 2aa5B-5kznA:
undetectable		 2aa5B-5kznA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 12 ASN A 153
LEU A 155
ALA A 152
GLN A 162
LEU A  37
 None
 1.15A 2aa6A-5kznA:
undetectable		 2aa6A-5kznA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 12 LEU A 154
ASN A 153
LEU A 155
ALA A 152
GLN A 162
 None
 1.37A 2aa6A-5kznA:
undetectable		 2aa6A-5kznA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_B_STRB402_1
(MINERALOCORTICOID
RECEPTOR)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 12 ASN A 153
LEU A 155
ALA A 152
GLN A 162
LEU A  37
 None
 1.15A 2aa6B-5kznA:
undetectable		 2aa6B-5kznA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_2
(POL POLYPROTEIN)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 12 LEU A  79
GLY A  85
ASP A  70
ILE A 140
ILE A  72
 None
 0.93A 2f81B-5kznA:
undetectable		 2f81B-5kznA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 12 LEU A  62
PHE A  38
LEU A  26
ILE A 378
VAL A 385
 None
 1.17A 2hrcA-5kznA:
4.0		 2hrcA-5kznA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 12 LEU A  62
PHE A  38
LEU A  26
ILE A 378
VAL A 385
 None
 1.11A 2hrcB-5kznA:
4.5		 2hrcB-5kznA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_2
(PROTEASE)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 9 LEU A  79
GLY A  85
ASP A  70
ILE A 140
ILE A  72
 None
 0.91A 2idwB-5kznA:
undetectable		 2idwB-5kznA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 12 PHE A 432
TYR A 386
ALA A 389
ALA A  86
GLY A  30
 None
 1.07A 2igtA-5kznA:
2.9		 2igtA-5kznA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 12 PHE A 432
TYR A 386
ALA A 389
ALA A  86
GLY A  30
 None
 1.08A 2igtB-5kznA:
2.3		 2igtB-5kznA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 12 PHE A 432
TYR A 386
ALA A 389
ALA A  86
GLY A  30
 None
 1.08A 2igtC-5kznA:
2.6		 2igtC-5kznA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 12 GLU A  55
ASN A 342
GLY A  58
GLN A  42
ILE A  59
 None
 1.16A 2ogyA-5kznA:
undetectable		 2ogyA-5kznA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		4 / 8 ARG A 183
SER A 173
ASP A 444
ALA A 170
 None
 1.38A 2rk8A-5kznA:
undetectable		 2rk8A-5kznA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		4 / 5 SER A 164
PHE A 181
VAL A 151
TYR A 165
 None
 1.29A 2x7hA-5kznA:
4.1		 2x7hA-5kznA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 12 LEU A  62
PHE A  38
LEU A  26
ILE A 378
VAL A 385
 None
 1.19A 3aqiB-5kznA:
4.3		 3aqiB-5kznA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		3 / 3 ARG A 177
ASP A 215
ASP A 174
 None
 0.79A 3jb3A-5kznA:
undetectable		 3jb3A-5kznA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 9 TYR A 458
THR A 316
TYR A 468
GLY A 296
ALA A 275
 None
 1.18A 3jusB-5kznA:
undetectable		 3jusB-5kznA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 10 ALA A 293
LEU A 279
VAL A 303
TYR A 216
THR A 316
 None
 1.18A 3jw3A-5kznA:
3.3		 3jw3A-5kznA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_1
(PROTEASE)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 12 LEU A  79
GLY A  85
ASP A  70
ILE A 140
ILE A  72
 None
 0.93A 3ndtC-5kznA:
undetectable		 3ndtC-5kznA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_1
(PROTEASE)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 12 LEU A  79
GLY A  85
ASP A  70
ILE A 140
ILE A  72
 None
 0.86A 3nduA-5kznA:
undetectable		 3nduA-5kznA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_1
(PROTEASE)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 12 LEU A  79
GLY A  85
ASP A  70
ILE A 140
ILE A  72
 None
 0.89A 3nduC-5kznA:
undetectable		 3nduC-5kznA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_1
(FIV PROTEASE)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 10 LEU A 278
ALA A 310
VAL A 304
GLY A 313
LEU A 279
 None
 0.84A 3ogqA-5kznA:
undetectable		 3ogqA-5kznA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_2
(PROTEASE)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 12 LEU A  79
GLY A  85
ASP A  70
ILE A 140
ILE A  72
 None
 0.92A 3pwmB-5kznA:
undetectable		 3pwmB-5kznA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 12 ALA A  98
LEU A 154
ILE A 136
GLY A  35
HIS A  87
 None
 0.97A 3q95A-5kznA:
undetectable		 3q95A-5kznA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 12 LEU A  99
ALA A  98
ILE A 136
GLY A  35
HIS A  87
 None
 0.89A 3q95B-5kznA:
undetectable		 3q95B-5kznA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		3 / 3 GLU A  55
PHE A 348
GLN A  60
 None
 1.01A 3r55A-5kznA:
undetectable		 3r55A-5kznA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_1
(PROTEASE)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 12 LEU A  79
GLY A  85
ASP A  70
ILE A 140
ILE A  72
 None
 0.95A 3tkgA-5kznA:
undetectable		 3tkgA-5kznA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 12 LEU A  62
PHE A  38
LEU A  26
ILE A 378
VAL A 385
 None
 1.16A 3w1wB-5kznA:
4.6		 3w1wB-5kznA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		4 / 7 MET A 195
ILE A 221
VAL A 265
TRP A 204
 None
 1.43A 4f4dA-5kznA:
3.2		 4f4dA-5kznA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		4 / 7 ASP A 188
GLU A 375
ASP A 295
GLU A 318
 None
 1.22A 4fewB-5kznA:
undetectable		 4fewB-5kznA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		3 / 3 PRO A  39
TYR A 144
GLY A 142
 None
 0.71A 4g2zA-5kznA:
undetectable		 4g2zA-5kznA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		4 / 8 ASP A 188
GLU A 375
ASP A 295
GLU A 318
 None
 1.20A 4gkhD-5kznA:
undetectable		 4gkhD-5kznA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PL1_A_SAMA401_0
(DUAL-SPECIFICITY RNA
METHYLTRANSFERASE
RLMN)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 11 PHE A 181
PRO A  39
SER A 167
ILE A 149
ASN A 153
 None
 1.31A 4pl1A-5kznA:
1.8		 4pl1A-5kznA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 11 LEU A  99
ALA A  98
ILE A 136
GLY A  35
HIS A  87
 None
 0.89A 4pxmB-5kznA:
undetectable		 4pxmB-5kznA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 9 ALA A 287
VAL A 241
GLY A 252
SER A 208
VAL A 210
 None
 1.25A 4r20B-5kznA:
undetectable		 4r20B-5kznA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_2
(HIV-1 PROTEASE)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 9 LEU A  79
GLY A  85
ASP A  70
ILE A 140
ILE A  72
 None
 0.90A 4rvjB-5kznA:
undetectable		 4rvjB-5kznA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_2
(HIV-1 PROTEASE)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 9 LEU A  79
GLY A  85
ASP A  70
ILE A 140
ILE A  72
 None
 0.89A 4rvjD-5kznA:
undetectable		 4rvjD-5kznA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP9_C_1WEC706_1
(TRANSPORTER)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		4 / 4 PHE A 269
ASP A 295
GLY A 220
SER A 294
 None
 1.45A 4xp9C-5kznA:
undetectable		 4xp9C-5kznA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		4 / 5 VAL A 381
TYR A 216
ILE A 221
PRO A 186
 None
 1.27A 4ze1A-5kznA:
undetectable		 4ze1A-5kznA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		4 / 6 LEU A 278
ALA A 281
LEU A 279
SER A 307
 None
 1.26A 5a6iA-5kznA:
undetectable		 5a6iA-5kznA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 10 ALA A 293
ALA A 275
VAL A 303
VAL A 304
TYR A 468
 None
 0.97A 5eb5B-5kznA:
undetectable		 5eb5B-5kznA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens) 		5 / 12 ALA A 275
GLY A 296
GLY A 298
ILE A 317
LEU A 199
 None
 1.07A 5ul4A-5kznA:
4.7		 5ul4A-5kznA:
21.22