SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kzs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 5kzs PUTATIVE CELL
SURFACE PROTEIN,
SIMILAR TO
INTERNALIN PROTEINS
(Listeria
monocytogenes) 		3 / 3 LEU A  93
SER A  89
ASN A  87
 None
 0.58A 1bx4A-5kzsA:
undetectable		 1bx4A-5kzsA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 5kzs PUTATIVE CELL
SURFACE PROTEIN,
SIMILAR TO
INTERNALIN PROTEINS
(Listeria
monocytogenes) 		4 / 6 LEU A 204
LEU A 231
LEU A 199
LEU A 175
 None
 0.94A 1errA-5kzsA:
undetectable		 1errA-5kzsA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5kzs PUTATIVE CELL
SURFACE PROTEIN,
SIMILAR TO
INTERNALIN PROTEINS
(Listeria
monocytogenes) 		4 / 8 GLN A 346
PHE A 347
ASN A 303
ASP A 349
 None
 1.29A 1p6kA-5kzsA:
undetectable		 1p6kA-5kzsA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5kzs PUTATIVE CELL
SURFACE PROTEIN,
SIMILAR TO
INTERNALIN PROTEINS
(Listeria
monocytogenes) 		4 / 8 GLN A 346
PHE A 347
ASN A 303
ASP A 349
 None
 1.31A 1p6kB-5kzsA:
undetectable		 1p6kB-5kzsA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 5kzs PUTATIVE CELL
SURFACE PROTEIN,
SIMILAR TO
INTERNALIN PROTEINS
(Listeria
monocytogenes) 		4 / 6 LEU A 336
GLU A 335
THR A 321
TYR A 310
 None
 1.11A 1qvuA-5kzsA:
undetectable		 1qvuA-5kzsA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5kzs PUTATIVE CELL
SURFACE PROTEIN,
SIMILAR TO
INTERNALIN PROTEINS
(Listeria
monocytogenes) 		4 / 8 GLN A 346
PHE A 347
ASN A 303
ASP A 349
 None
 1.24A 1rs6A-5kzsA:
undetectable		 1rs6A-5kzsA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5kzs PUTATIVE CELL
SURFACE PROTEIN,
SIMILAR TO
INTERNALIN PROTEINS
(Listeria
monocytogenes) 		4 / 8 GLN A 346
PHE A 347
ASN A 303
ASP A 349
 None
 1.28A 1rs6B-5kzsA:
undetectable		 1rs6B-5kzsA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5kzs PUTATIVE CELL
SURFACE PROTEIN,
SIMILAR TO
INTERNALIN PROTEINS
(Listeria
monocytogenes) 		4 / 8 GLN A 346
PHE A 347
ASN A 303
ASP A 349
 None
 1.32A 1zzqA-5kzsA:
undetectable		 1zzqA-5kzsA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5kzs PUTATIVE CELL
SURFACE PROTEIN,
SIMILAR TO
INTERNALIN PROTEINS
(Listeria
monocytogenes) 		4 / 8 GLN A 346
PHE A 347
ASN A 303
ASP A 349
 None
 1.32A 1zzqB-5kzsA:
undetectable		 1zzqB-5kzsA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5kzs PUTATIVE CELL
SURFACE PROTEIN,
SIMILAR TO
INTERNALIN PROTEINS
(Listeria
monocytogenes) 		4 / 8 GLN A 346
PHE A 347
ASN A 303
ASP A 349
 None
 1.33A 1zzuB-5kzsA:
undetectable		 1zzuB-5kzsA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_B_DESB800_1
(ESTROGEN RECEPTOR
ALPHA)		 5kzs PUTATIVE CELL
SURFACE PROTEIN,
SIMILAR TO
INTERNALIN PROTEINS
(Listeria
monocytogenes) 		5 / 10 MET A  90
ALA A  96
LEU A  75
LEU A  72
LEU A  78
 None
 1.46A 3erdB-5kzsA:
undetectable		 3erdB-5kzsA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5kzs PUTATIVE CELL
SURFACE PROTEIN,
SIMILAR TO
INTERNALIN PROTEINS
(Listeria
monocytogenes) 		5 / 12 VAL A 345
ASP A 349
PHE A 347
ILE A 267
LEU A 295
 None
 1.07A 3hj3D-5kzsA:
undetectable		 3hj3D-5kzsA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 5kzs PUTATIVE CELL
SURFACE PROTEIN,
SIMILAR TO
INTERNALIN PROTEINS
(Listeria
monocytogenes) 		5 / 7 VAL A 104
LEU A 125
TYR A 149
PHE A 130
LEU A 143
 None
 1.45A 3qeoB-5kzsA:
undetectable		 3qeoB-5kzsA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 5kzs PUTATIVE CELL
SURFACE PROTEIN,
SIMILAR TO
INTERNALIN PROTEINS
(Listeria
monocytogenes) 		4 / 8 ILE A 122
LEU A  93
PHE A  80
LYS A  56
 None
 1.04A 3selX-5kzsA:
undetectable		 3selX-5kzsA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5kzs PUTATIVE CELL
SURFACE PROTEIN,
SIMILAR TO
INTERNALIN PROTEINS
(Listeria
monocytogenes) 		5 / 9 ASP A  47
ILE A  85
GLY A  49
VAL A 106
GLY A  79
 None
 1.32A 4acaB-5kzsA:
undetectable
4acaC-5kzsA:
undetectable		 4acaB-5kzsA:
22.32
4acaC-5kzsA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5kzs PUTATIVE CELL
SURFACE PROTEIN,
SIMILAR TO
INTERNALIN PROTEINS
(Listeria
monocytogenes) 		4 / 7 GLN A 346
PHE A 347
ASN A 303
ASP A 349
 None
 1.37A 4kcnB-5kzsA:
undetectable		 4kcnB-5kzsA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5kzs PUTATIVE CELL
SURFACE PROTEIN,
SIMILAR TO
INTERNALIN PROTEINS
(Listeria
monocytogenes) 		4 / 8 LEU A 247
VAL A 261
LEU A 209
LEU A 231
 None
 0.98A 4l1xA-5kzsA:
undetectable		 4l1xA-5kzsA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 5kzs PUTATIVE CELL
SURFACE PROTEIN,
SIMILAR TO
INTERNALIN PROTEINS
(Listeria
monocytogenes) 		5 / 9 ASN A 255
ILE A 291
GLY A 272
SER A 309
VAL A 345
 None
 1.29A 4r20B-5kzsA:
undetectable		 4r20B-5kzsA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_A_TFPA203_1
(CALMODULIN)		 5kzs PUTATIVE CELL
SURFACE PROTEIN,
SIMILAR TO
INTERNALIN PROTEINS
(Listeria
monocytogenes) 		4 / 8 PHE A  80
ILE A  85
LEU A  50
MET A  54
 None
 0.66A 4rjdA-5kzsA:
undetectable		 4rjdA-5kzsA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5kzs PUTATIVE CELL
SURFACE PROTEIN,
SIMILAR TO
INTERNALIN PROTEINS
(Listeria
monocytogenes) 		5 / 12 PHE A 238
ILE A 166
LEU A 226
LEU A 224
LEU A 202
 None
 1.14A 4xumA-5kzsA:
undetectable		 4xumA-5kzsA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5kzs PUTATIVE CELL
SURFACE PROTEIN,
SIMILAR TO
INTERNALIN PROTEINS
(Listeria
monocytogenes) 		5 / 12 ASP A 250
ILE A 291
GLY A 357
PHE A 347
GLY A 272
 None
 0.98A 5i71A-5kzsA:
undetectable		 5i71A-5kzsA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5kzs PUTATIVE CELL
SURFACE PROTEIN,
SIMILAR TO
INTERNALIN PROTEINS
(Listeria
monocytogenes) 		5 / 12 ASP A 250
ILE A 291
GLY A 357
PHE A 347
GLY A 272
 None
 0.94A 5i73A-5kzsA:
undetectable		 5i73A-5kzsA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 5kzs PUTATIVE CELL
SURFACE PROTEIN,
SIMILAR TO
INTERNALIN PROTEINS
(Listeria
monocytogenes) 		4 / 4 ASN A 207
LEU A 209
SER A 227
LEU A 224
 None
 1.17A 5kb5A-5kzsA:
undetectable		 5kb5A-5kzsA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5kzs PUTATIVE CELL
SURFACE PROTEIN,
SIMILAR TO
INTERNALIN PROTEINS
(Listeria
monocytogenes) 		3 / 3 ASN A 237
PRO A 258
GLN A 294
 None
 0.92A 6jnhA-5kzsA:
undetectable		 6jnhA-5kzsA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5kzs PUTATIVE CELL
SURFACE PROTEIN,
SIMILAR TO
INTERNALIN PROTEINS
(Listeria
monocytogenes) 		3 / 3 ASN A 237
PRO A 258
GLN A 294
 None
 0.91A 6jogA-5kzsA:
undetectable		 6jogA-5kzsA:
19.23