SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kzt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 5kzt PEPTIDE/NICKEL
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Listeria
monocytogenes) 		5 / 12 TYR A 143
GLY A 456
PHE A 193
LEU A 466
SER A 463
 None
 1.09A 1fduA-5kztA:
undetectable		 1fduA-5kztA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 5kzt PEPTIDE/NICKEL
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Listeria
monocytogenes) 		4 / 7 GLN A 417
ASP A 418
LEU A 524
SER A 412
 None
 1.19A 1ig3A-5kztA:
undetectable
1ig3B-5kztA:
undetectable		 1ig3A-5kztA:
19.84
1ig3B-5kztA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_B_MTXB352_1
(PTERIDINE REDUCTASE
1)		 5kzt PEPTIDE/NICKEL
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Listeria
monocytogenes) 		5 / 12 SER A 451
LEU A 468
LEU A 514
LEU A 515
PRO A 523
 None
 1.43A 1p33B-5kztA:
undetectable		 1p33B-5kztA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 5kzt PEPTIDE/NICKEL
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Listeria
monocytogenes) 		4 / 6 LEU A  49
GLU A  51
TYR A 531
TYR A 551
 None
 1.18A 1qvuA-5kztA:
undetectable		 1qvuA-5kztA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_B_NCAB508_0
(NAD-DEPENDENT
DEACETYLASE 2)		 5kzt PEPTIDE/NICKEL
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Listeria
monocytogenes) 		4 / 5 GLN A 533
LEU A 540
TYR A 549
TYR A 531
 None
 1.40A 1yc2B-5kztA:
undetectable
1yc2C-5kztA:
undetectable		 1yc2B-5kztA:
19.25
1yc2C-5kztA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 5kzt PEPTIDE/NICKEL
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Listeria
monocytogenes) 		4 / 7 ASP A 461
THR A 357
ASN A 362
GLN A 501
 None
 0.85A 2jc9A-5kztA:
undetectable		 2jc9A-5kztA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5kzt PEPTIDE/NICKEL
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Listeria
monocytogenes) 		4 / 7 SER A 463
ARG A 503
TYR A 459
TYR A 186
 None
 1.41A 2vmyA-5kztA:
undetectable
2vmyB-5kztA:
undetectable		 2vmyA-5kztA:
20.07
2vmyB-5kztA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5kzt PEPTIDE/NICKEL
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Listeria
monocytogenes) 		4 / 8 TYR A 459
TYR A 186
SER A 463
ARG A 503
 None
 1.33A 2vmyA-5kztA:
undetectable
2vmyB-5kztA:
undetectable		 2vmyA-5kztA:
20.07
2vmyB-5kztA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 5kzt PEPTIDE/NICKEL
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Listeria
monocytogenes) 		4 / 4 GLY A 456
ASP A 548
GLY A  68
THR A 195
 None
 1.10A 3k4vC-5kztA:
undetectable		 3k4vC-5kztA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5kzt PEPTIDE/NICKEL
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Listeria
monocytogenes) 		4 / 6 LEU A 468
PHE A 469
ILE A 521
THR A 302
 None
 1.08A 3mdrA-5kztA:
undetectable		 3mdrA-5kztA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD305_0
(GLUTATHIONE
TRANSFERASE GTE1)		 5kzt PEPTIDE/NICKEL
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Listeria
monocytogenes) 		4 / 4 ILE A 255
LEU A 252
LYS A 253
ASN A 256
 None
 1.39A 4g19D-5kztA:
undetectable		 4g19D-5kztA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 5kzt PEPTIDE/NICKEL
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Listeria
monocytogenes) 		3 / 3 ARG A 324
LYS A 325
LYS A 321
 None
 1.08A 4k50A-5kztA:
undetectable		 4k50A-5kztA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 5kzt PEPTIDE/NICKEL
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Listeria
monocytogenes) 		3 / 3 ARG A 324
LYS A 325
LYS A 321
 None
 1.06A 4k50E-5kztA:
undetectable		 4k50E-5kztA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 5kzt PEPTIDE/NICKEL
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Listeria
monocytogenes) 		3 / 3 ARG A 324
LYS A 325
LYS A 321
 None
 1.07A 4k50I-5kztA:
undetectable		 4k50I-5kztA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 5kzt PEPTIDE/NICKEL
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Listeria
monocytogenes) 		4 / 7 HIS A 373
ASN A 350
VAL A 508
ALA A 510
 None
 0.88A 4p6sA-5kztA:
undetectable		 4p6sA-5kztA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 5kzt PEPTIDE/NICKEL
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Listeria
monocytogenes) 		4 / 8 ASP A 113
ARG A 111
PRO A 121
TRP A 116
 None
 1.05A 4uhxA-5kztA:
undetectable		 4uhxA-5kztA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 5kzt PEPTIDE/NICKEL
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Listeria
monocytogenes) 		4 / 8 ASP A 113
ARG A 111
PRO A 121
TRP A 116
 None
 1.05A 4uhxA-5kztA:
undetectable		 4uhxA-5kztA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 5kzt PEPTIDE/NICKEL
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Listeria
monocytogenes) 		4 / 7 PHE A 196
ALA A 149
SER A 181
LEU A 166
 None
 0.92A 4uymA-5kztA:
undetectable		 4uymA-5kztA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 5kzt PEPTIDE/NICKEL
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Listeria
monocytogenes) 		5 / 12 ILE A  55
GLY A 231
ALA A  58
PHE A 220
VAL A  72
 None
 1.22A 5hw4C-5kztA:
undetectable		 5hw4C-5kztA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 5kzt PEPTIDE/NICKEL
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Listeria
monocytogenes) 		4 / 7 HIS A 373
ASN A 350
VAL A 508
ALA A 510
 None
 0.92A 5i3bA-5kztA:
undetectable		 5i3bA-5kztA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 5kzt PEPTIDE/NICKEL
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Listeria
monocytogenes) 		3 / 3 GLN A 444
THR A 142
ASP A  64
 None
 0.90A 5k9dA-5kztA:
undetectable		 5k9dA-5kztA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 5kzt PEPTIDE/NICKEL
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Listeria
monocytogenes) 		3 / 3 LYS A 306
GLN A 441
ASN A 445
 None
 1.07A 5l2tA-5kztA:
undetectable		 5l2tA-5kztA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5kzt PEPTIDE/NICKEL
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Listeria
monocytogenes) 		4 / 4 VAL A 135
LEU A 146
ASN A 152
ASP A 155
 None
 1.14A 5vcyA-5kztA:
undetectable		 5vcyA-5kztA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 5kzt PEPTIDE/NICKEL
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN
(Listeria
monocytogenes) 		5 / 12 LEU A 466
LEU A 514
PHE A 469
ILE A 521
THR A 302
 None
 1.27A 6debB-5kztA:
undetectable		 6debB-5kztA:
10.70