SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kzy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A84_A_DXCA1161_0 (MAJOR POLLEN ALLERGEN BET V 1-A)	5kzy	SMOOTHENED (Xenopus laevis)	5 / 12	PRO A 137 LEU A 140 TYR A 103 VAL A 102 SER A 69	CY8 A1201 ( 4.9A) None None None None	1.40A	4a84A-5kzyA: undetectable	4a84A-5kzyA: 21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QOP_A_HQEA503_1 (CATALASE)	5kzy	SMOOTHENED (Xenopus laevis)	5 / 9	ILE A 95 LEU A 99 TYR A 103 PHE A 139 ASP A 68	None None None None CY8 A1201 (-4.2A)	1.42A	4qopA-5kzyA: undetectable	4qopA-5kzyA: 12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QOP_B_HQEB503_1 (CATALASE)	5kzy	SMOOTHENED (Xenopus laevis)	5 / 9	ILE A 95 LEU A 99 TYR A 103 PHE A 139 ASP A 68	None None None None CY8 A1201 (-4.2A)	1.43A	4qopB-5kzyA: undetectable	4qopB-5kzyA: 12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QOP_D_HQED503_1 (CATALASE)	5kzy	SMOOTHENED (Xenopus laevis)	5 / 9	ILE A 95 LEU A 99 TYR A 103 PHE A 139 ASP A 68	None None None None CY8 A1201 (-4.2A)	1.43A	4qopD-5kzyA: undetectable	4qopD-5kzyA: 12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EML_A_SAMA701_0 (PROTEIN ARGININE N-METHYLTRANSFERASE 5)	5kzy	SMOOTHENED (Xenopus laevis)	5 / 12	GLY A 135 PRO A 137 LEU A 140 ARG A 90 LEU A 85	None CY8 A1201 ( 4.9A) None None CY8 A1201 (-4.1A)	1.47A	5emlA-5kzyA: undetectable	5emlA-5kzyA: 10.93

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4A84_A_DXCA1161_0","MAJOR POLLEN ALLERGEN BET V 1-A","5kzy","SMOOTHENED","Xenopus laevis",5,"PRO A 137;LEU A 140;TYR A 103;VAL A 102;SER A  69","CY8 A1201 ( 4.9A);None;None;None;None","1.40A","4a84A-5kzyA:undetectable","4a84A-5kzyA:21.02"],["4QOP_A_HQEA503_1","CATALASE","5kzy","SMOOTHENED","Xenopus laevis",5,"ILE A  95;LEU A  99;TYR A 103;PHE A 139;ASP A  68","None;None;None;None;CY8 A1201 (-4.2A)","1.42A","4qopA-5kzyA:undetectable","4qopA-5kzyA:12.70"],["4QOP_B_HQEB503_1","CATALASE","5kzy","SMOOTHENED","Xenopus laevis",5,"ILE A  95;LEU A  99;TYR A 103;PHE A 139;ASP A  68","None;None;None;None;CY8 A1201 (-4.2A)","1.43A","4qopB-5kzyA:undetectable","4qopB-5kzyA:12.70"],["4QOP_D_HQED503_1","CATALASE","5kzy","SMOOTHENED","Xenopus laevis",5,"ILE A  95;LEU A  99;TYR A 103;PHE A 139;ASP A  68","None;None;None;None;CY8 A1201 (-4.2A)","1.43A","4qopD-5kzyA:undetectable","4qopD-5kzyA:12.70"],["5EML_A_SAMA701_0","PROTEIN ARGININE N-METHYLTRANSFERASE 5","5kzy","SMOOTHENED","Xenopus laevis",5,"GLY A 135;PRO A 137;LEU A 140;ARG A  90;LEU A  85","None;CY8 A1201 ( 4.9A);None;None;CY8 A1201 (-4.1A)","1.47A","5emlA-5kzyA:undetectable","5emlA-5kzyA:10.93"]]